I’Jaz Al-Qur’an Al-Karim an Evaluation of Historical Discourse and Dimensions

This paper aims at an evaluation of various approaches to define and redefine the classical theory of the I‘jaz (the inimitability of the Qur’ān) in the perspective of the challenges and problems faced by the Muslim society emphasising a need to cope with the rational thinking, modernity, scientific progress, psychological advancement and civilizational development, though there has been a comparatively lesser description of the rhetoricism of the Qur’ān too. It provides an account of scholarship exploring some novel dimensions of the matchlessness of the Qur’ān in the contemporaneous context. They have justified rationally and psychologically the Qur’ānic historic challenge of producing a book or its some surahs or few verses similar to the Qur’ān that has offered the irresistible call to the whole mankind: “Say: “If the whole of mankind and Jinns were to gather together to produce the like of this Qur’ān, they could not produce the like thereof, even if they backed up each other with help and support”. (Al-Isra 17: 88) The same challenge occurs in the Qur’ān on three previous occasions (Al-Baqarah, 2: 23-24; Yunus 10: 38, and Hūd 11: 13) and later also in al-Tūr (52: 33-34). The content of all the verses referred to above is in response to the allegation of the unbelievers that the Qur’ān had been composed by the Prophet (peace be on him) and then falsely ascribed to God. All this was refuted. This refutation of the Qur’ān was logically established by the modern Arabic scholars through their sound arguments.

Comparative Investigation of Natural and Synthetic Iron Chelating Agents in Experimental Animals.

Iron is vital and an essential requirement for most plants and animals to maintain the homeostasis of iron through a series of chemical reactions.Normally, the amount of iron in the human body is closely regulated, with a balance being achieved between the amount lost and that absorbed from the diet. Regular blood transfusions in thalassemia and other chronic refractory anemia can result due to the excessive iron deposition in tissues and organs. The regulation of this vital but potentially toxic substance, when present in excessive amounts, can negatively affect several physiological processes in the human body. The present study was conducted to evaluate the compartive efficancy of some natural and synthetic chelating agents towards chelation of iron in the experimental animals. Medicinal plants including amrood (Psidium guajava), green tea (Camella sinesis), turmeric (Curcuma longa) and khatti (Citrus aurentifolia) were evaluated for their natural chelating potential against iron overload in the experimental animals.The extracts from the selected medicinal plants were evaluated for their antioxidant activity, antimicrobial activity, cytotoxicity,along with GC-MS and FTIR phytochemicals profiling. Iron overload was induced by administration of iron sulphate and IROSE (iron sucrose) to the experimental animals. The experiments were conduted to evaluate selective parameters such as serum ferritin, immune status and liver enzymes etc., along with histopathological status of different body organs like liver, kidney and spleen of the model animals. Iron overload caused tissue damage in the experimental animals and also increased the concentration level of biochemical parameters in the serum. The plant derived natural chelating agents/extracts, administrated orally, restored the biochemical parametres and tissue injury of different soft organs of the the experiomnetal animals leading towards the normal state. It can be concluded from the findings of the present study that the tested medicinal plants had appreciable chelation ability to excrete the excess iron from different organs of the thalassaimic patients and thus can be explored as a sustainable source for isolation of natural iron chelating agents to replace the synthetic ones.