1H-indene derivatives were prepared by intramolecular gold-catalyzed reaction of β-alkyl, βalkanol o-(alkynyl)styrenes by formal 5-end-dig fashion involving Pinacol-Pinacolone group migration followed by protodemetalation and deprotonation. The synthesis of mono- and disubstituted o-(alkynyl)styrene derivatives (5a-e). Synthesis of β-alkanol o-(alkynyl)styrenes 6a-f and β-alkyl,β-alkanol o-(alkynyl)styrenes 7a-j has been also illustrated through the reduction and addition of organolithium/Grignard reagents. Gold catalyzed cyclization of β-alkyl, βalkanol o-(alkynyl)styrenes afforded 1H-indene derivatives (10a, 10b, 10e, 10f) involving the nucleophilic attack of internal carbon based nucleophile onto the activated gold-alkenyl complex followed by subsequent Pinacol-Pinacolone type migration. In the second part, synthesis of bis(N-methyl-N-phenylcarbamoyl)polysulfanes having linearly linked sulfurs (S= 1 to 4), have been presented. Characterization techniques like NMR, mass spectrometry and single crystal Xray crystallographic analysis have been also incorporated. Comparative study of N,N′-dimethylN,N′-diphenylurea B1 (commercially available compound) and N,N′-dimethyl-N,N′diphenyloxamide B2 is also illustrated. The third part deals with the physicochemical behavior and interaction of [Ni(phen)3]F2.EtOH.MeOH.8H2O (NPC) with anionic surfactants (sodium dodecyl sulphate SDS, sodium stearate SS, sodium ethyl hexyl sulfate SEHS and sodium docusate SD). Critical micelle concentration (CMC) and spectroscopic parameters were determined by UV/Vis spectroscopy and thermodynamic parameters of complex-surfactant interactions were determined by electrical conductivity measurements. NPC showed the tendency of partitioning in the following order SDS ˃SS˃SEHS˃SD and CMC increased in the presence of micellar media. The investigated Ni-complex showed quite significant antioxidant activity against DPPH, hemolytic activity against RBCs, while no substantial cytotoxic activity against 3T3 cell line was witnessed.