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Investigation on the Antioxidant and Antimutagenic Potential of Selected Indigenous Medicinal Plants.

Thesis Info

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Author

Yasir, Muhammad

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/9840/1/Muhammad_Yasir_Chemistry_UAF_2015.docx

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726514279

Similar


The present study has been designed to investigate the antioxidant and antimutagenic potential of hydrolyzed and non-hydrolyzed extracts of twenty medicinal plants belonging to different plant families like Amaranthaceae, Cucurbitaceae, Labiatae, Fabaceae, Solanaceae, Poaceae, Malvaceae and Zygophyllaceae. Hydrolyzed extraction was carried out using acidified methanol and non-hydrolyzed extracts were obtained with aqueous methanol. Both types of extracts were evaluated for phenolic contents, antioxidant, mutagenic and antimutagenic potential and genoprotective activity. Hydrolyzed extracts of all plants represented higher phenolic contents, antioxidant and antimutagenic potential as compared to non-hydrolyzed extracts. Mentha longifolia (402.8±1.9 mg GAE/g dry extract), Citrullus colocynthus (396.4±1.9 mg GAE/g dry extract) and Mimordica dioca (354.4±1.9 mg GAE/g dry extract) showed highest phenolic contents. Cassia angustifolia (230.4±2.6 mg AAE/g dry extract), Mimordica dioca (132.6±0.8 mg AAE/g dry extract) and Mentha longifolia (131.7±1.5 mg AAE/g dry extract) presented largest reducing power in terms of ascorbic acid equivalents (AAE). Highest free radical scavenging was shown by Citrullus colocynthus (96.21±1.0%; IC50 2.11±0.12 µg/mL), Achyranthus aspera (93.1±0.4%; IC50 6.5±0.10 µg/mL), Mentha longifolia (92.4±1.0%; IC50 14.3±0.1 µg/mL). Citrullus colocynthus (96.21±1.0%; IC50 2.11±0.12 µg/mL), Mimordica dioca (91.91±1.0%; IC50 17.22±0.36 µg/mL) and Mentha longifolia (92.4±1.0%; IC50 14.3±0.1 µg/mL) exhibited highest antioxidant activity in terms of inhibition to lipid peroxidation. Lowest cytotoxicity was observed for Citrullus colocynthus (2.65±0.09%), Achyranthus aspera (2.95±0.14%) and Mentha longifolia (3.95±0.08%) by evaluating haemolytic activity. Highest antimutagenic potential was calculated for hydrolyzed extracts of Citrullus colocynthus (75.79±0.69%), Mimordica dioca (73.02±1.37%) and Achyranthus aspera (72.22±0.69%). Also, Citrullus colocynthus, Mimordica dioca and Achyranthus aspera showed considerable protection against oxidatively damaged DNA plasmid i.e. pBR322. Finally, it has been concluded that Citrullus colocynthus, Mentha longifolia, Mimordica dioca and Achyranthus aspera were the most bioactive plants of all selected medicinal plants as represented by the results of LCMS analysis that exhibited the presence of high concentrations of bioactive compounds in the extracts of these plants.…………………………………
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اظہارِ تشکر

اظہارِ تشکر
اقرار مصطفیٰ
اللہ تبارک و تعالیٰ کے نہایت فضل و کرم اور نبیِ مکرمﷺ کے وسیلہ ٔ جمیلہ کے سبب نعتیہ مجموعہ’’ حسنِ کُن‘‘(مسدسِ مصطفیٰؐ)مسدس کی صورت میںمکمل ہوا۔ عہدِ رواں انتشار و خلفشار اور طرح طرح کے زوالی فتنوں کا عہد ہے۔ مسائل کی فراوانی اور وسائل کی کم یابی کے باعث ضروریات ِ حیات کو پورا کرنا وبالِ جان بن چکا ہے۔ ایسے میں خواہشات کی تکمیل کے لیے پر تولنا ، کم فہمی اور دیوانے کے خواب کے مترادف ہے۔مگر کچھ خواہشات ،ضروریات ِ حیات سے بھی بڑھ کے ہوتی ہیں کیوں کہ ان کا تعلق ایمان ومحبت سے جڑا ہوتا ہے اور اہلِ ایمان و محبت کا اعتقاد و یقین سے بھرپور او رمسلم نظریہ یہ ہے کہ تعلقِ خاطر خالصتاً نبی ِ آخرالزماں ﷺ سے ہو تو خواہشوں کی تکمیل کے خواب کو تعبیر میں ڈھلنے کے اسباب خود بہ خود پیدا ہوجاتے ہیں یا اسباب پیدا کر دیے جاتے ہیں۔ موجودہ نامساعد حالات کے پیشِ نظر ، مجھ ایسے کم مایا کا مجموعہ منصہ شہود پر آنا درحقیقت احمد رضاؒ خاں بریلوی کے اس شعر کے مصداق ہے:
کون دیتا ہے دینے کو منہ چاہیے
دینے والا ہے سچا ہمارا نبیؐ
عزیزانِ من! حُسنِ کُن‘‘مسدس کی ہئیت میں لکھا گیا ہے۔ اسمِ محمدﷺ اور اسمِ احمدﷺ کے اعداد کا مجموعہ 145بنتا ہے، اسی نسبت سے مسدس کے بندوں کی تعداد 145رکھی گئی ہے اور اسی وجہ کے پیشِ نظر اس میں خصوصی طور پہ یہ التزام ملحوظ رکھا گیا ہے کہ یہ موضوع ، موضوعِ نعت ہے اور یہ سراپا نعت ہی رہے۔
الحمد للہ!’’ حُسنِ کُن‘‘ (مسدسِ مصطفیٰؐ) حسنِ نعت سے مزین ہے۔ پھر بھی یہ بات اپنی جگہ صد فی صد درست ہے کہ:
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