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Home > Isolation and Structural Studies on the Bioactive Constituents of Bergenia Ciliata and Synthesis, Special Characterization and Antibacterial Study of a Schiff Base Metal Complexes

Isolation and Structural Studies on the Bioactive Constituents of Bergenia Ciliata and Synthesis, Special Characterization and Antibacterial Study of a Schiff Base Metal Complexes

Thesis Info

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Author

Ullah Khan, Farman

Program

PhD

Institute

Gomal University

City

Dera Ismail Khan

Province

KPK

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13175/1/Farman_Ullah_Khan.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726541716

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The indigenous plant Bergenia ciliata was investigated for bioactive constituents in this research. Five known bioactive compounds were isolated from ethyl acetate extract of this plant. The isolated compounds were identified by melting point, UV, IR, 1H-NMR and 13C-NMR as Afzelechin (173), Asarone (174), Terpinen-4-ol (175), Parasorbic acid (176)and Damascenone (177). Antimicrobial activity of isolated compounds was studied. All the isolated constituents showed antimicrobial efficiency varyingly on the selected microbes that comprised of two Gram positive and four Gram negative bacterial strains, causes infections in human. Afzelechin (173) exhibited the highest antimicrobial activity compared to other compounds. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the constituents which were explored for the first time. Afzelechin (173) showed the highest antifungal activity while Damascenone (177) has moderate activity. The second part of the thesis is comprised of Synthesis of Schiff bases and their complexation with different metals like Cu (II), Co (II), Ni (II) and Zn (II). Both the bases and their complexes were studied on the basis of their physical characterization like micro-analytical data, 1HNMR, FTIR and UV spectrum data. Schiff bases coordination with metal through nitrogen of imine and atom of oxygen was confirmed through spectrum data. Furthermore, the ligand and the metal complexes were screened against Gram positive and Gram negative bacteria for their antibacterial activity. The results showed that these complexes possess enhanced biological activity as compared to ligand bases.
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ڈاکٹر مصطفی حسن علوی

ڈاکٹر مصطفےٰ حسن علوی
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The Life and Achievements of Hyder Bux Jatoi, With an Special Reference to His Social and Political Contributions

Comrade Hyder Bux Jatoi, also known as ‘Baba e Sindh’, was the most prominent leader of the farmer societies of pre-independence Pakistan. Although he was a bureaucrat turned into a farmer activist, but later he played a very important role in the social and political settings of the country at that time. Most of the Pakistani people remember him as a sign of change and renovation in the agricultural history of Pakistan. This was a great effort to credit the front-runners and their struggle; it is very prominent among the laborers and landless leaders of the world. He devoted his entire life to set peace up for the struggle of land ownership rights to dispossessed farmers, and highlighted the cause, to be noticed by the notables. The vision of Mr. Jatoi is still reflected in many situations when initiatives are taken by the various governments of the world to provide the masses with the basic requirements of development and peace.

Ction O Seed H of Health in Cere Eals Bas Sed on Predic Se Eed Dete Eriorat Ting Fac Ctors a and Thei Ir Manageme Ent

Poaceae, the cereals is one of the most important plant families, which have the potential to provide readily available protein and cheap carbohydrates than any other food commodity for both animals and human consumption. The growing third world population and its domestic animals need more cost-effective protein and carbohydrates which, although in abundance in many developing countries, are under-utilized. In Pakistan widely cultivated cereal crops are wheat (Triticum aestivum L.) rice (Oryza sativa L.) and maize (Zea mays L.) while barley (Hordeum vulgare L.), millet (Pennisetum typhoides [(Burm.) Staff. & Hub.)], oats (Avena sativa L.), sorghum (Sorghum vulgare L.) and rye (Secale cereale L.), are the minor cereals. Many fungi are serious parasites of seed primordia, maturing and stored seeds or grains. Fungal contamination of three stored cereals varied with type of host, storage duration and conditions. The fungi isolated from different seed sources of three hosts through blotter paper, agar plate and deep freezing methods. Both pathogenic fungi including species of Alternaria, Bipolaris, Fusarium, Helminthosporium, Macrophomina, Drechslera, Pyricularia and Nigrospora and saprophytic fungi like species of Aspergillus, Absidia, Chaetomium, Curvularia, Epicoccum, Monilia, Mucor, Penicillium and Rhizopus were predominant. During storage period, the germination percentage recorded as 91% at the temperature (Temp.) of 21.9°C with relative humidity (RH) of storage at 53.5%. The germination percentage gradually decreased as the duration of storage prolonged even the RH value slightly changed but temperature value (28.5°C) rose significantly. Change in temperature and relative humidity had no significant influence on the critical values of seed vigour, it slightly affects seed vigour at the temperature ranging 22-41 °C and RH ranging 35-65%. Moisture level of stored wheat, rice and maize significantly increased and became more than twice (23.5, 26.5 and 26%) respectively than its starting level (11%) after 135-140 days of storage duration. The level of protein, carbohydrates, fats and crude fiber content of these cereals exhibited slight changes but no significant under the four different environmental conditions during storage. Among the Aspergillus isolates from wheat maximum level of aflatoxins were recorded from Aspergillus parasiticus as 745-783 of AFB1, 17.24-87.36 of AFG1 followed by AFB2 (49.57-137.03) and AFG2 in low quantities (26.5 -67.42 ng/g ). During the management trials involving seed coating with plant extracts and essential oils, the maximum seed germination percentage (77.33, 75, 69 and 69%) was obtained in the case of neem treated seeds in all storage durations (0, 60,120 and 180 days respectively) as compared with negative control (53.33%) and other treatments. This trend line recorded similar as the storage duration prolonged upto 60, 120 and 180 days.