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Isolation and Synthesis of Polycyclic Systems

Thesis Info

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Author

Khan, Madiha Sahar

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/971

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676726547301

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شورشؔ کاشمیری

شورش کاشمیری
شورش کاشمیری کی وفات بھی بڑا سانحہ ہے، ان کی نشوونما آزادیٔ ہند کی جدوجہد کے دوران ہوئی، انھوں نے آزادیٔ وطن کے علم برداروں کے ساتھ زندگی کا بڑا حصہ گزارا، مولانا آزاد، عطاء اﷲ شاہ بخاری اور مولانا ظفر علی خان سے انھیں گہرا تعلق تھا، ملک کی تقسیم سے پہلے ان کا قیام لاہور میں تھا، آزادی کے بعد وہ وہیں رہ گئے، لیکن انھیں وہاں کبھی اطمینان نصیب نہیں ہوا، ان کی زندگی کا بڑا حصہ جیلوں میں بسر ہوا، کبھی کبھی دارورسن کا خطرہ بھی ہوا مگر ان کے پائے ثبات کو کبھی لغرش نہیں ہوئی وہ بڑے قادر الکلام شاعر اور پرزور خطیب تھے، ان کا زور بیان اور حسن کلام مولانا ظفر علی خاں کی یاد دلاتا تھا، اعلان حق میں بڑی جری تھے اور اس راہ میں شدائد و مصائب سے کبھی ہراساں نہیں ہوئے، زندگی بھر تکلیفیں برداشت کرتے رہے، مگر کبھی باطل سے سمجھوتہ نہیں کیا، وہ دارالمصنفین کے بڑے ہمدرد اور بہی خواہ تھے اور اس کی خدمت و اعانت کے لئے ہمیشہ تیار رہتے تھے، اﷲ تعالیٰ ان کو اپنے سایۂ رحمت میں جگہ دے اور ان کی حق گوئی کا پورا صلہ عطا فرمائے۔ (عبد السلام قدوائی ندوی، نومبر ۱۹۷۵ء)

 

عبادات(نماز و زکاۃ): قرآنی سیاق و سباق کے تناظر میں ذہنی سکون کا منبع

This is the well-known fact that ebadat are the most important articles of Islam. Ebadat bring many spiritual and material benefits to worshipers (Muslim), and this included peace of mind and satisfaction of heart. This point is discussed in this article in detail with reference to the relevant verses of Quran and Prophetic Sunnah in the light of Tafaseer perspectives. A person who bow to Allah Almighty sincerely, he offers prayers in time and pay Zakat to get the Will of Allah, he becomes a great man who is blessed with peace of mind as being agree in every condition with believing in Allah SWT being as satisfaction for him and makes him free from mental tension and anxiety. In the view of Quran e Kareem, the main reason for giving details of the rewards and benedictions of the Paradise is to develop satisfaction within the hearts of the worshipers. It is observed that only the way of attaining real peace of mind and satisfaction of heart is to be punctual and regular in offering prayers and paying zakat sincerely realization in the true sense.

Evaluation of Different Stress Indicators Associated With Repproductive Cyclicity of Crossbred Dairy Cows

Eminent environmental temperature has adverse affect on dairy cattle production and reproduction. The periparturient period is also very critical for reproductive functions of dairy cows. A variety of methods are used to improve fertility in these stress conditions. The present study was conducted under a series of three experiments to find out stress-reproduction relationship and effect of vitamin E on this interaction. Study-I, was conducted to assess physiological and reproductive changes, in relation to heat stress in different dairy cattle breeds in various seasons. A total of thirty six lactating dairy cows, nine from each breed of local (Sahiwal and Achai), Cross-bred (Sahiwal x HF) and Holstein Friesian were selected. Sampling was conducted when the cows were in the di-estrus phase of the estrus cycle in February (thermoneutral), April (thermotransitional) and June (thermal stress) at an average environmental temperature of 18°C, 32°C and 42°C respectively. A significant decrease in Daily milk yield (DMY) was observed in all breeds with increase in environmental temperature (P < 0.01). DMY also varied significantly (P < 0.001) among breeds. The HF dairy cows showed the highest mean DMY followed by cross-bred, Sahiwal and Achai at all the three seasons. BCS was not affected by environmental temperature; however, BCS varied among breeds significantly (P < 0.01). A significant increase in all the physiological parameters (rectal temperature, respiratory rate and pulse rate) was observed in all dairy cows with increase in environmental temperature during thermo transitional and summer seasons in April and June respectively. Thermal stress in June increased concentrations of glucose (P= 0.014), cortisol (P < 0.001), heat shock protein-70 (HSP-70) (P < 0.001) and follicular numbers (P < 0.01), while decreased progesterone concentrations (P < 0.01) in all four breeds as compared to February. DMY and progesterone level are negatively correlated with environmental temperature. Glucose and cortisol levels were positively correlated with each other and negative with Progesterone. Positive correlation was found between glucose, cortisol and HSP-70 with rise in environmental temperature. However progesterone was negatively correlated with these parameters at high environmental temperature. It is concluded that the intensity of changes was higher in HF and cross-bred dairy cows than local Achai and Sahiwal, suggesting that extra managemental and therapeutical support is needed to improve fertility of these breeds in tropical regions. Study-II, was designed to detect the occurrence of oxidative stress in dairy cows by determining the plasma malondialdehyde (MDA) concentration during the periparturient period and its possible relationship with dairy cows fertility. Thirty-six periparturient lactating dairy cows, nine from each breed of Sahiwal, Achai, Cross-bred (Sahiwal x HF) and Holstein Frisian were selected. Sampling was conducted on post partum day (P.P.Day) 60, 82 and 105 of the lactation stage during the diestrus period of the estrus cycle. DMY varied significantly with P.P Days and among breed (P < 0.001). Highest DMY was shown by HF followed by cross-bred, Sahiwal and lowest by Achai. The interaction (PP.Days x Breed) effect was also highly significant (P < 0.01) for DMY. Serum glucose concentration significantly increased with increase in PP.Days (P < 0.01). Breed also affected glucose concentration (P < 0.001). A decrease in MDA concentrations were observed with increase in PP.Days (P < 0.001) from P.P day-60 to 82 and 105. Breed also affected the MDA concentrations significantly (P < 0.001), more prominent in HF and cross-bred. Both P.P. Days and breed significantly affected the serum cortisol concentration (P < 0.001). The cortisol concentration significantly decreased from P.P day-60 to 82 and 105. Progesterone level increased in all breeds (P < 0.05) with increase in P.P. Days (P < 0.001) from day-60 to 82, continued up to day-105. BCS was negatively correlated with serum cortisol, glucose and progesterone. Cortisol, DMY and MDA were positively correlated with each other and negative with progesterone and P.P. Days. The study revealed that HF and cross-bred dairy cows were more prone to oxidative stress than local breeds. Correlations analysis indicates that high milk production delayed ovarian activity effecting the reproduction of periparturient cows as assessed by progesterone concentrations. Therefore, it is suggested that higher genetic merit milk breeds should give extra managemental support for their better productivity and fertility. Study-III, was designed to find out the response of different breeds to vitamin E supplementation in combating stress and improving reproductive cyclicity. The experiment was conducted on thirty six lactating dairy cows, nine from each breed of Sahiwal, Achai, Cross-bred (Sahiwal x HF) and Holstein Frisian. Vitamin E was supplemented to all dairy cows in feed at a dose rate of 1000 IU/ cow/ day. Sampling was conducted on day-zero (control) before Vitamin E supplementation, day-20 and day-40 of Vitamin E supplementation during the diestrus phase of the estrus cycle. Daily milk yield and BCS varied significantly among breeds (P < 0.001) with no significant effect of vitamin E. Serum glucose increased significantly (P < 0.05) with vitamin E supplementation, but did not varied among breeds significantly. There was significant increase in SOD and GPx with vitamin E supplementation (P < 0.001). Breeds also varied in super oxide dismutase (SOD) and glutathione per oxidase (GPx) activities (P < 0.05, P < 0.001 respectively) with more increase in GPx in local dairy breeds. Stress markers, plasma MDA and HSP-70 and serum cortisol concentrations decreased significantly (P < 0.001) with vitamin E supplementation with significant variations among breeds (P < 0.001). Progesterone concentration increased significantly (P < 0.001) in all breeds with vitamin E. Breed effect on progesterone concentrations was also found significant (P < 0.05). Local breeds showed higher progesterone concentration while overall increase was found higher in Cross-bred dairy cows (39.95%). Number of dominant follicles decreased significantly with vitamin E supplementation (P < 0.01) in all the dairy breeds, highest in cross-bred dairy breeds. Breed also showed significant effect on number of follicles (P < 0.05). DMY showed positive correlation with MDA and negative with SOD, GPx and progesterone. The stress markers (cortisol, HSP-70 and MDA) were positively correlated with each other and glucose concentration while negative with antioxidant markers. Antioxidant markers were positively correlated with progesterone. It can be concluded that improved milk breeds showed more prominent response to vitamin E supplementation than local breeds suggesting regular feeding of antioxidant to these breeds for better performance.