خواجہ عزیز الحسن غوری
اس ماہ گذشتہ کا دوسرا حادثہ حضرت خواجہ عزیز الحسن صاحب غوری مجذوب کی وفات ہے، مرحوم حضرت مولانا تھانویؒ کے محبوب خلفاء میں تھے، گو کہ وہ عالم نہ تھے، گریجویٹ تھے، عمر بھر اعلیٰ سرکاری ملازمت کی، مگر ان کو اﷲ تعالیٰ کی طرف سے وہ قلب خاشع اور وہ تقوی عطا ہوا تھا، جس پر بڑے بڑے علماء کو رشک ہونا چاہیے، اور شعر وسخن کی محفل میں وہ بلبل گویا تھے، کہ جس کے سریلے نغموں سے ایک مدت تک اہل درد لذت پاتے رہیں گے، اﷲ تعالیٰ جنت الفردوس ان کی آرام گاہ بنائے۔
(سید سلیمان ندوی، ستمبر ۱۹۴۴ء)
There is no doubt that Islam is a religion of peace which ensures peace regionally and globally in the light of its teachings. It is not only a religion of worship, but it is a religion includes ethics and caring for others and takes care of the rights of individuals as well as society. The life of Prophet Muhammad, r is the best role model in creating world peace atmosphere as He had ordered his followers and believers to realize peace in their societies. Islam guarantees peace even in war situation as it provides full protection and refuge to all those innocents who do not participate in the war. It is not unknown now that the contemporary world is witnessing events that souls hate and hearts alienate which caused racisms and populism and that their effects threatened communities and destroy firm foundations of peace. So in this contemporary perspective, the importance of research and writing about world peace increases subject to all of the studies levels, whether in universities or conferences especially in light of the biography of Holy Prophet Muhammad r. In this research, I will focus on the following points: Peace and its practical examples in of Holy Prophet Muhammad r. Explanation about the concept of peace and its practice in life of Holy Prophet Muhammad r. Clarifying the most prominent contemporary security challenges in the light of the Prophet's biography. Discussion on common misconceptions about Global peace matter and their correction in the sacred Biography of the Prophet Muhammad r
Introduction: Molecular characterisation of the breast cancer has allowed for targeted therapies that are improving outcomes. The gains achieved by these treatments have fuelled the search for other targets, including cyclin-dependent kinase inhibitors such as p21. p21 expression in breast cancer has been shown to be variably associated with clinical and pathological parameters in different populations. It is possible that either methodological or biological differences underlie these variations.
Objective: The current study sought to determine the association of p21 expression and clinico-pathological parameters in breast cancer patients at the Aga Khan University Hospital in Nairobi, Kenya.
Methods: Clinically annotated tissue samples were obtained in a consecutive fashion. Specimen were immunohistochemically stained for p21 expression with clinicopathological data extracted for corresponding cases. p21 expression was assessed against age, parity, menopausal status, body mass index, hormonal receptor status, tumour size and grade. Distribution of mean p21 score was assessed for normality and data were analysed using Kruskall-Wallis test, chi-square and Fisher's exact test at an alpha level of 0.05. They were presented in form of tables, charts and photomicrographs.
Results: Ninety-eight cases were included in the study. Mean age was 47.55 years with mean parity 2.96 live births. A slight majority of patients were pre-menopausal (56.3% versus 42.5%). Average body-mass index was 29.69 kilograms per square metre. Majority of patients had invasive ductal carcinoma (87.6%) that was moderate-to-high grade (92.7%), 2 centimetres or larger (95%), with lymphovascular invasion (70.4%), and vi hormone-receptor positive. Mean expression of p21 at 1:100 dilution was approximately 20% was statistically significant with tumour size.
Conclusion: The findings of the current study demonstrate a possible association of p21 expression with tumour size. The demonstration of a trend towards p21 loss with increasing body mass index may benefit from exploration with a larger dataset.