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Home > Modification and Characterization of Wild and Commercial Gums for Their Pharmaceutical Potential

Modification and Characterization of Wild and Commercial Gums for Their Pharmaceutical Potential

Thesis Info

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Author

Munir, Hira

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Subject

Natural Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/2730/1/2719S.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726663888

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The present study was conducted to investigate the pharmaceutical potential of wild and commercial gums. After the process of purification, Dalbergia sissoo and Acacia modesta were selected for the present research among the eight initially selected gums. For the use of gum as binder in tablet the physiochemical characteristics such as pH, fluorescence analysis, swelling index and rheological studies were determined. Both selected gums were acidic in nature. D. sissoo and A. modesta showed light brown and creamy color in fluorescent analysis, respectively. The viscosity measurements were made by the rheological analysis and D. sissoo and A. modesta provide different rheological pattern. The aqueous solution of crude A. modesta was more viscous than D. sissoo. Carbohydrates were present in high concentrations determined through proximate and biochemical analysis. The elemental profiles of crude gums were studied by the laser induced breakdown spectroscopy (LIBS) and significant number of elements was recorded. Crude gums exhibited a number of drawbacks in their application that can be overcome by hydrolyzed and modified to improve the functional properties of biopolymers. The selected gum were hydrolyzed (acidic, basic and enzymatic) and modified (polyacrylamide grafting and carboxymethylation).The antioxidant activities of crude, hydrolyzed and modified gums were determined and the selected samples exhibited significant antioxidant potential. The antimicrobial, toxicological studies viz. antimutagenic and hemolytic analyses were performed. All the tested gums samples exhibit good antibacterial activity. All samples were found non-mutagenic to Salmonella typhimurium TA 98 and TA 100, and did not show significant hemolytic activity. The structural characterization was carried out by scanning electron microscope, 12 thermogravimetric analysis, differential scanning colorimetry, Fourier transform infrared spectroscopy, X-ray diffraction. The change in viscosity after hydrolysis and modification was analyzed by performing the flow test. There was a decrease in viscosity of crude gum after hydrolysis and modification. Gum based silver-nanoparticles were prepared on the basis of green chemistry principle and possess important microbial applications. Nanoparticles prepared by using both gum showed synergistic high antibacterial activity. The potential of D. sissoo and A. modesta to be used as tablet binder was determined. Bulk and tapped density, hausner’s ratio and carr’s index of the prepared granules were studied. After the formation of tablets, the weight uniformity, hardness, friability, disintegration time and drug release were determined. Hydroxypropyl Methycellulose (HPMC) is used as standard binder. The prepared tablets using gums showed faster and slower dissolution profiles in the same dissolution system. The crude gums have the highest dissolution rate. While the dissolution rate was decreased in the case of modified and hydrolyzed gum samples. The crude gums showing slower release can be useful in sustained release tablets as release controlling polymer / viscoslysing agent. And the hydrolyzed and modified gums having faster release rate are helpful in conventional tablet formulation. The current research comprehensively explored the selected gums for their application as biobinder as well as matrix for nanoparticles studies. In future, these results of selected gum may be used in pharmaceutical field on the pilot or industrial scale as biobinder and other applications like prebiotic for probiotics and green material for nanoscience etc.
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انور نعمانی

انور نعمانی مرحوم
علامہ شبلیؒ نعمانی نے اپنے بھائی مولوی محمد اسحاق مرحوم وکیل الہ آباد ہائی کورٹ کی موت پر اپنے ایک پر درد نوحہ میں یہ فرمایا تھا۔
مرنے والے کو نجات ابدی کی ہو نوید
خوش و خرم رہے چھوٹایہ مرا بھائی جنید
ان ہی جناب جنید نعمانی کے مرحوم کے اکلوتے بیٹے انور نعمانی مرحوم تھے، جنھوں نے لگ بھگ اسّی۸۰ سال کی عمر میں کراچی میں مئی ۱۹۸۶؁ء کے آخری ہفتہ میں وفات پائی، مرحوم اپنے والد بزرگوار کے سایۂ عا طفت میں بڑے لاڈ پیار اور ناز ونعمت سے پلے، تعلیم مسلم یو نیو رسٹی علی گڑھ میں پائی، گھر میں دولت تھی، اس لئے ان کو نوکری کرنے کی ضرورت نہیں پڑی، کچھ دنوں مرزا پور میں فارم کیا، چھوٹی موٹی تجارت بھی کی، پھر حضرت مولانا اشرف علی تھانویؒ کے خلیفہ مولانا عبدالغنی پھولپوری کے ایسے گرویدہ اور فریضتہ ہوئے کہ وہ نقل وطن کرکے کراچی چلے گئے تو یہ بھی اپنا گھربار سب کچھ چھوڑ کر ان ہی کے ساتھ وہاں رہنے لگے، جب تک اعظم گڑھ میں رہے دارالمصنفین والوں کے یار وفادار اور غم گسار بن کر ان کے لئے اپنی محبت کا دم بھرنا زندگی کا شعار بنائے رکھا۔ کراچی میں ان کے اکلوتے لڑکے سرکاری نوکر ہیں، اچھے حال میں ہیں ،پھر ان کے اور قریبی اعزہ بھی وہاں بہت خوش حال ہیں، مگر انھوں نے کسی کے یہاں رہنا پسند نہیں کیا، اپنے مرشد کی ایک پسند یدہ مسجد سے ملحق ایک کٹیا ان ہی کے نام پر ایک عبادت گاہ کے گوشے میں رہ کر اپنی بقیہ زندگی گذاردی، کراچی جب جب گیا، ان سے جاکر ضرور ملا، اور ان کی پرانی زندگی کی یادوں کی قندیل روشن کی، کسی زمانے میں صاحب کی طرح زندگی بسر کرنے والے کو ان...

Comparison of Economic Activities: Time Deposits, Investments, Income and Needs

This article aims to discuss the comparison of economic activities including time deposits, investment, income and needs. The advantage of a bank by raising reserves through stores is that the cash put away can take longer, considering that stores have a moderately long period of time and the recurrence of withdrawals is additionally uncommon. Hence the bank can unreservedly utilize the credit of these stores. Income in common is regularly related to the sum of cash an individual gets as a result of something done, done, or contributed. The pay is at that point utilized or went through to meet different needs in life for a certain period of time. It is vital to have Financial Management by giving need scale by prioritizing all things that are vital since the more noteworthy a person's pay more often than not the more he needs. The survey results within the AES business group show a significant comparison of the amount of income derived from investment and sales that generate income, while time deposits are rarely performed as a principal economic activity in generating income.

Experimental Study of the Behaviour of Pre-Perforated Post-Reinforced Baked Clay Panels of Beams

Altogether fifty one large size beams of clay were moulded, compacted, baked, post- reinforced, grouted with cement-sand slurry, cured and tested to study the behaviour of these beams. Different parameters were set in order to check the suitability of these universally available materials of construction, i.e. clay, silt and pit-sand (silica) for low- cost housing without sacrificing durability, the strength and elegance of buildings in the plain areas where the soil is alluvial. Standard materials of construction like hill-sand, coarse aggregate, cement and steel bars are to be transported over large distances for RCC construction. Four Reinforced concrete beams were also cast and tested for the sake of comparison. Preliminary studies were carried out on soil samples collected from twenty five different sites in terms of their physical composition and presence of various salts and other chemicals. Their effect on the strength of baked specimens was also studied. A systematic study was performed experimentally to find the best composition in terms of ratio (clay : pit-sand), the intensity of compression force required for manual moulding and compaction which would impart reasonably good crushing strength to this material (comparable with that of concrete) without compromising on economy. The moisture content was also a parameter of preliminary experimental study to ensure sufficient workability and minimum possible void ratio. The various drying techniques were tried finally to arrive at the best possible system which would not cause cracking. The compressive strength as high as (6100 psi ) 42 N/mm2 has been achieved which can be compared with (3000 psi ) 20 N/mm2 for concrete used in ordinary buildings. The modulus of rupture with a reasonable comparison to ordinary concrete has also been achieved. Flexural behaviour as well as shear strength of beams manufactured from this material were studied for the following cases. 1. Rectangular beams, simply supported subjected to point load at the centre. 2. I-beams, simply supported subjected to point load at the centre. 3. Rectangular beams, supported on plates on both the ends subjected to Uniformly Distributed Load. 4. Rectangular beams, fixed at both the ends subjected to Uniformly Distributed Load 5. Rectangular as well as I-section beams, simply supported with only bottom steel consisting of two bars. 6. Rectangular beams reinforced with four bars two at top and two at bottom, simply supported subjected to Uniformly Distributed Load. 7. Rectangular beams with vertical steel as shear reinforcement, simply supported subjected to Uniformly Distributed Load. 8. Rectangular as well I-section beams subjected to pre-compression to improve the shear strength and simply supported beams subjected to point load at centre and also with Uniformly Distributed Load. 9. Rectangular beams with enhanced compacting force, simply supported as well as plate support on both the ends subjected to point load at centre and also with Uniformly Distributed Load. The beams tested were relatively of large size, 1980 mm (6.5 ft) long, 150 mm (6 inch) thick and 300 mm (12 inch) deep. After shrinkage the final dimensions were determined and the average shrinkage was found, 1868 mm (6.13 ft), 143 mm (0.47 ft) and 286mm (0.94 ft). Several problems were faced and attempts were made to over-come those through various techniques, the details of which are presented in this thesis. The results are encouraging and there is a bright possibility to achieve reasonably good economy if pre-cast panels of this type of materials are produced on mass scale by adopting mechanized system for swift moulding, transportation to the site and erection of the buildings.