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Home > Multiple Biomarker Approach for the Assessment of Genotoxicity in Major Carps Treated With Domestic Waste and Industrial Effluents Discharge Through Chakbandi Drain into River Chenab, Pakistan

Multiple Biomarker Approach for the Assessment of Genotoxicity in Major Carps Treated With Domestic Waste and Industrial Effluents Discharge Through Chakbandi Drain into River Chenab, Pakistan

Thesis Info

Access Option

External Link

Author

Rana, Muhammad Arshad

Program

PhD

Institute

Government College University

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Zoology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/14606/1/35049.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726734868

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In this investigation, composite drain water concentrations were collected from five selected sites of Chakbandi drain in the month of April, May and June, 2016. These composite drain water concentrations were applied to fingerling’s of selected fish species namely, Catla catla, Labeo rohita and Cirrhinus mrigala in laboratory conditions. LC50 were determined and sub-lethal dilutions i.e. 20%, 25%, 30%, 35% and 40% of drain water were tested for acute toxicity trial from April to June, 2016. All the water quality parameters i.e. DO, pH, temperature, conductivity, TDS, salinity, TSS, BOD and COD and ten selected heavy metals (Cu, Cr, Mn, Cd, Co, Ni, Sn, Hg, Zn and Pb) recorded from drain water were found to be above the admissible limits as suggested by FAO/ WHO. Bioaccumulation of these ten heavy metals in the muscle tissues of fish species revealed highly significant variations. Cirrhinus mrigala showed the higher level of bioaccumulation of heavy metals in their muscles when compared with Labeo rohita and Catla catla. Among all the treated fish species, Catla catla showed the maximum growth performance with respect to Labeo rohita and Cirrhinus mrigala. The control fish showed more growth performance than the treated fish group. Maximum mean WBCs were recorded from Cirrhinus mrigala whereas minimum from Catla catla. Similarly, minimum level of RBCs, Hb, HCT and MCV were recorded from Cirrhinus mrigala in comparison with treated and control groups. In this study, DNA damage was quantified in the fish peripheral erythrocytes through different types of damaged cells. Maximum frequency for DNA damaged cells was measured in the erythrocytes of Cirrhinus mrigala than Labeo rohita and Catla catla. Cirrhinus mrigala exhibited the maximum average tail DNA length and average tail moment when compared with Labeo rohita and Catla catla. Maximum mean total no. of cells with micronuclei and maximum micronuclei frequency was recorded in erythrocytes of Cirrhinus mrigala than Labeo rohita and Catla catla. When histopathological analysis of control and treated fish was compared, control fish manifested the normal structures than treated fish which reflected various alterations with respect to liver, kidney, gills and muscles. Conclusively, all the multiple biomarkers performed the reliable role for the evaluation o environmental pollution.Furthermore, multiple biomarker findings are conducive to an early prognosis for environmental management and may assist us in planning strategies to minimize the ecotoxicological impacts of pollutants reaching in freshwater reservoirs, aquatic fauna, particularly fish and indirectly human populations.
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سیدہ آمنہ کی وفات

سیدہ آمنہؓ کی وفات
سیدہ آمنہؓ اپنے شوہر کی وفات کے بعد ان کی قبر کی زیارت کے لیے نہیں جا سکی تھی ۔ اب انہیں موقع ہاتھ لگا تو اپنے لخت جگر کو جن کی عمر چھ سال کے لگ بھگ تھی اور ام ایمن کو ساتھ لیے شوہر کے مزار پر حاضری دینے کے لیے سوئے مدینہ روانہ ہوئیں ۔ ایک ماہ قیام کرنے کے بعد واپسی کا راستہ لیا ۔ قدرت خدا کی دیکھیے کہ راستے میں بیمار ہوئیں اور ابواء کے مقام پر پہنچیں تو ان کا آخری وقت قریب آ گیا اور وفات پا گئیں ابواء کے مقام پر دفن کر کے ام ایمن سیدالصادقین ﷺ کو لے کر مکہ آئیں اور عبدالمطلب کو اس واقعہ سے آگاہ کیا آپ کو بہت دکھ ہوا ‘ولادت سے پہلے باپ چل بسا اور اب والدہ بھی اللہ کو پیاری ہوگئیں اس حال میں یتیم پوتے کو سینے سے لگا کر رو پڑے انہوں نے آپ ﷺکو اپنی کفالت میں لے لیا اور والدین کی کمی محسوس نہ ہونے دی ۔
اہم نکتہ: بعض سیرت نگاروں نے لکھا ہے کہ سیدہ آمنہ ؓمدینہ میں اپنے رشتے داروں کو ملنے گئی تھیں یہ بعید از قیاس ہے کیونکہ سیدہ آمنہ کی اپنی ذاتی رشتہ داری نہ تھی ۔ اگر یہ بات کہی جاتی کہ سیدہ آمنہؓ اپنے سسرال کے رشتہ داروں سے اپنے نور نظر کی شناسائی کے لیے تشریف لے گئی تھیں تو بجا ہوتا کیونکہ وہ سسرالی رشتہ دار تھے اور سسرال کی ننھیال بہت دور کی رشتہ داری کی بات ہے اور علامہ شبلی کہتے ہیں کہ میرے نزدیک بعض مورخین کا یہ بیان درست ہے کہ حضرت آمنہ ؓاپنے شوہر کی قبر کی زیارت کے لیے گئی تھیں جو مدینہ میں مدفون تھے بعض مورخین نے لکھا ہے کہ آمنہ...

ﺗﺎرﻳﺦ اﻟﺘﺼﻮف اﻹﺻﻼﺣﻲ ﻓﻲ ﺷﺒﻪ اﻟﻘﺎرة اﻟﻬﻨﺪﻳﺔ وﻧﻤﺎذج ﻣﻦ اﻟﻤﺼﻠﺤﻴﻦ ﻣﻦ اﻟﻤﺘﺼﻮﻓﺔ

Sufism/mysticism has played a vital role in preaching of Islam throughout the world especially in the sub-continent. The great Sufi Scholars influenced the moral and social behavior of the people of Sub continent. The discussion in this article deals with the role of Sufism in bringing moral and social revolution among the people of Sub- continent. The great Sufis of Sub-continent including Ali bin Usman Hajwari and Moin-ud-Din Chishti spread the peaceful message of Islam all over India. These great Sufis followed the pure Sufism based on Islamic Shariah which brought a great change in Indian Society especially their moral behavior.

Probing New Physics Through Semileptonic Flavor Changing Neutral Current Transition

In this thesis, the exclusive semileptonic rare B-mesons decays which are induced by the flavor changing neutral current transition (FCNC) have been studied within and beyond the Standard Model (SM). To probe physics beyond the SM, B → K ∗ + − , B → K1 + − level, these FCNC transitions arises as b → s ∗ , B → K2 + − + − and Bc → D∗ s + − decays are considered. At quark and, in the SM, are forbidden at tree level but are allowed at loop level through Glashow-Iliopoulos-Maiani (GIM) mechanism. Moreover, FCNC transitions are further suppressed due to the fact that they are directly proportional to the off diagonal elements of the Cabibo Kobayashi Maskawa (CKM) matrix. Because of these two conditions FCNC transitions are relatively rare and become important to investigate the physics beyond the SM, usually known as new physics (NP). The important points of the thesis are in order: • We study the exclusive channel of flavor changing neutral current transition (FCNC) i.e. B → K ∗ + − in the frame work of a family of non-universal Z model. In this model, the Z boson couplings to the fermions could lead to FCNC transition at tree level. In addition, the off-diagonal elements of these effective chiral Z couplings can contain new weak phases that provide a new source of CP violation and, therefore, could explain the CP asymmetries in the current high energy colliders. In this context, we have studied the polarized and unpolarized CP violation asymmetries for the said decay. These asymmetries are highly suppressed in the standard model but significantly enhanced in the Z model. In addition to the CP violation asymmetries, the single lepton polarization asymmetries are also studied and found them sensitive to the couplings of the Z boson. Finally, it is analyzed that all these asymmetries which will hopefully be tested at LHC can serve to probe the non-universal Z model, particularly, the accurate measurements of these asymmetries may play a crucial role to extract the precise values of the coupling parameters of Z boson. • The sensitivity of the zero position of the forward backward asymmetry AFB for the exclusive B → K1 (1270)μ+ μ− decay is examined by using most general non-standard 4-fermion interactions. Our anal- ysis shows that the zero position of the forward backward asymmetry is very sensitive to the sign and size of the Wilson coefficients corresponding to the new vector type interactions, which are the counter partners of the usual Standard Model operators but have opposite chirality. In addition to these, the other significant effect comes from the interference of Scalar-Psudoscalar and Tensor type operators. These results will not only enhance our theoretical understanding about the axial vector mesons but will also serve as a good tool to look for physics beyond the SM. • A detailed study of the impact of New Physics (NP) operators with different Lorentz structures, which ∗ are absent in the Standard Model Hamiltonian, on the B → K2 (1430)μ+ μ− decay is performed. In this context, the various observables such as branching ratio, forward-backward asymmetry of leptons, lepton ∗ polarization asymmetries and the helicity fractions of the final state K2 (1430) meson have been studied. We have examined the effects of new vector-axial vector, scalar-pseudoscalar and tensor type interactions for ∗ this decay B → K2 (1430)μ+ μ− by using the constraints on different NP couplings which come from the ̄ ̄ Bs → μ+ μ− , B → X s μ+ μ− and B → K ∗ μ+ μ− decays. It is found that the effects of V A, S P and T operators are significant on the zero position of AFB (q2 ) as well as on its magnitude. In addition to this these NP operators also give significant effects on the differential decay rate, lepton polarization asymmetries and ∗ helicities fractions of final state K2 (1430) meson. • The semileptonic Bc → D∗ s + − ( = μ, τ) decays have been studied in the Standard Model (SM) and in the Universal Extra Dimension (UED) model. In addition to the contribution from the Flavor Changing Neutral Current (FCNC) transitions the weak annihilation (WA) contribution is also important for this decay because ∗ of enhanced CKM matrix elements Vcb Vcs . It is found that the WA gives 6.7 times larger branching ratio than the penguin contribution for the decay Bc → D∗ μ+ μ− . The contribution from the WA and FCNC transitions s are parameterized in terms of the form factors. In this work we first relate the form factors through Ward identities and then express them in terms of g+ (0) which is extracted from the decay Bc → D∗ γ through QCD s sum rules approach. These form factors are then used to analyze the physical observables like branching ratio and helicity fractions of the final state D∗ meson in the SM. This analysis is then extended to the UED s model where the dependency of above mentioned physical observables depend on the compactification radius R. It is shown that the helicity fractions of D∗ are sensitive to the UED model especially when we s have muons as the final state lepton. This sensitivity is marked up at low q2 region, irrespective of the choice of the form factors. It is hoped that in the next couple of years LHC will provide enough data on the Bc → D∗ s + − channel, and then , these helicity fractions would serve as a useful tool to establish new physics predicted by the UED model.