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Home > Neuropharmacological Studies on Memory Enhancing and Reinforcing Effects of Cns Stimulants in Rats Exposed to Unpredictable Repeated Stress

Neuropharmacological Studies on Memory Enhancing and Reinforcing Effects of Cns Stimulants in Rats Exposed to Unpredictable Repeated Stress

Thesis Info

Access Option

External Link

Author

Kanwal, Sumera

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Biochemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13534/1/Sumera_Kanwal_Biochemistry_2016_UOK_Karachi.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726749426

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There is growing increase in the prevalence of depression and obesity. In addition there is growing need of cognitive enhancers. CNS stimulants seem to be effective alternative for all these therapies but are addictive. Apomoprhine, a D1/D2 agonist also produces CNS stimulant like effects. The present study is designed to monitor antidepressant and cognitive improving effects of apomorphine, methylphenidate and caffeine in rats exposed to unpredictable repeated stress. Antidepressant like effects was monitored as the ability of drug to reduce stress effects on locomotion in a familiar as well as novel environment. Reinforcing effects of drug were monitored as drug-induced behavioral sensitization and place preference in a CPP paradigm. Cognitive performance and drug-induced enhancement of learning and memory were monitored in a Morris Water Maze Test. Apomoprhine, methylphenidate and caffeine exhibit antidepressant like effects by producing hyperlocomtion and anorexia. Long term administration of moderate dose of apomorphine and low doses of methylphenidate and coffee produces sensitization and enhances CPP greater in stressed animals. However when apomorphine is experienced during the exposure of unpredictable repeated stress it suppresses stress effects and enhances locomotion, drug induced sensitization was also smaller. Single as well as repeated administration of low dose of methylphenidate enhances short term and long term memory whereas high dose enhances memory retention and produces sensitization and reinforcement. Coffee is also effective in reducing stress-induced cognitive impairment, but reinforcing when taken at high dose specially for stressful conditions. The present study shows that CNS stimulants such as methylphenidate and caffeine can reduce stress effects and may be useful for the treatment of depression. Apomorphine which also produces CNS stimulant like effects is also similarly effective. Moreover the present results tend to suggest that psychostimulant as well as apomorphine can improve cognitive performance and alleviate stress-induced memory impairment. Psychostimulant as well as apomorphine have addictive potential and should not be used for long term.
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خلیج نغمہ

خلیج نغمہ

غروب آفتاب کے بعد ہم بس میں سوار ہوئے تو رہبر نے عربی زبان میں اعلان کیا کہ اب ہم خلیج نغمہ جائیں گے ۔کچھ دیر کی مسافت کے بعد ہم خلیج نغمہ کے ایک پر رونق بازار میں تھے ۔خلیج سویز کے کنارے آباد اس خوبصورت قصبے میں عیش و نشاط کے سارے سامان میسر تھے ۔یہاں کسینو ،مساج سنٹراور شراب خانوں کے ساتھ ساتھ ایسے متعدد ہوٹل بھی ہیں جہاں حلال خوراک اور سمندری غذائوں پر مشتمل کھانے دستیاب ہیں ۔ ہوٹلوں کے کارکن گاہکوں کو اپنی طرف راغب کر نے کے نت نئے طریقے اور سلیقے اپنائے ہوئے تھے ۔دکانیں فرعونی تہذیب سے منسلک اشیا ء میں فرعونی مجسموں کی بھرمار تھی ۔قلو پطرہ اور نفرتیتی کے مجسمے کچھ زیادہ ہی تعداد میں تھے جبکہ ابوالھول کے مجسمے تو چوراہوں میں بھی لگے تھے ۔ابوالھول اور قلو پطرہ کے ناموں سے مجھے واقفیت تھی مگر نفرتیتی میرے لیے بالکل نیا نام تھا ۔دکتور محمد علی کہ نفرتیتی فرعون بادشاہ اخناتون کی بیو ی تھی جو بہت حسین و جمیل اور امورِ حکمرانی کا فہم رکھنے والی خاتون تھی ۔مذہب کے حوالے سے بھی اس کی شہرت باقی فرعونی ملکائوں سے مختلف ہے ۔ اخناتون نے جب مذہب تبدیل کیا اور آمون کے خدائوںسے انکار کر کے خدائے یکتا پر ایمان کا اعلان کیا تونفرتیتی نے بھی ان کا بھرپور ساتھ دیا۔تاریخ نفرتیتی کی خوبصورتی کے ساتھ ساتھ اس کے ایک اورعمل سے بھی پردہ اٹھاتی ہے ۔کہا جاتا ہے کہ چشمِ غزال اور دلکش خدو خال رکھنے والی نفرتیتی جنسی عمل میں نت نئے انداز اپنانے کے لیے بھی شہرت رکھتی تھی ۔فرعونیات کے ماہرین کے مطابق دنیا میں ’’اور ل سیکس ‘‘دہن لذتی کی ابتدا ء اس خاتون سے ثابت ہے ۔کہا جاتا ہے کہ اس کے حنوط...

An Analysis of Sociocultural Barriers on Social Empowerment of Women in Sahiwal Division

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