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Home > Ochratoxicosis in Chicken: Pathological, Biochemical Alterations and Tissue Residues

Ochratoxicosis in Chicken: Pathological, Biochemical Alterations and Tissue Residues

Thesis Info

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Author

Hameed, Muhammad Raza

Program

PhD

Institute

University of Agriculture

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Botany

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2064

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726791026

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Ochratoxin A (OTA) exerts nephrotoxic, hepatotoxic and carcinogenic effects in animals and humans. OTA is also responsible to induce oxidative stress and immunosuppression. The presence of OTA as a common contaminant of cereal based food and feed ingredients has been reported from different regions of the World including Pakistan. Keeping in view the toxic significance of OTA, the present study was planned to study the pathological effects of OTA in chicken, with a focus to develop a relationship of pathological alterations associated with age, exposure duration, dietary and tissue/organ ochratoxin levels. Experiments were conducted to induce acute ochratoxicosis in one day old (experiment 1) and 21 day old (experiment 2) broiler chicks by feeding rations containing 0, 1.6, 3.2, and 6.4 mg/kg OTA for 10 days. Chronic ochratoxicosis was induced in day old broiler chicks by feeding 0, 0.05, 0.1, 0.2, 0.4 and 0.8 mg/kg OTA for duration of 21 (experiment 3) and 35 days (experiment 4). Different parameters studied included feed intake, body weight, organ weights, clinical signs, gross and microscopic morphological alterations in different organs/tissues, immunological responses, oxidative stress parameters and OTA tissue residues. Present study concluded that the ochratoxicosis in broiler chicks resulted in the poor feed intake, weight gain and performance of birds, increased mortality and severity of clinical signs in dose dependent manners. OTA feeding in broilers resulted in the suppression of immunological responses and decreased blood and tissue antioxidant potentials. OTA related decrease in antioxidant potential and immunosuppression was directly proportional to the dose and duration of OTA exposure. OTA exposure in older birds resulted in more severe oxidative stress but lesser immunosuppression as compared to birds exposed at young age. Dose related increase and age related development of resistance to the pathological and biochemical alterations were also recorded. Decreased carnosine, anserine and creatine contents of muscles following OTA exposure suggested the production of low nutritional and keeping quality chicken meat. Exposure of OTA both acute and chronic dietary levels resulted in the accumulation of OTA residues in liver, kidney and muscles of the birds although these residues quickly disappear after withdrawal of toxin contaminated diets.
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المبحث السادس: محاولة إرضاء الحبيب بعد الخصام

المبحث السادس: محاولة إرضاء الحبيب بعد الخصام

قصيدة (خصام) لنازك الملائكة ([1])

زمانُ الصفاء مضی وتلاشی مع الذکریات
وھا نحن مختصمان
وجاء زمانُ الصراع فلا لطفَ لا بسمات
ولا دفقۃٌ من حنان

وھا نحنُ مختصمان دفنّا ا لوئام
وراء التوتر في قعر ألفاظنا الباردہ
ولم نبقِ کأساً ولا منھلاً([2] ) للغرام 
ولم نُبق عشاً لأحلامنا الساھدہ([3] )

وھا نحنُ نکشف عمّا انطوی
بأعماق أنفسنا من عیوبٍ جمیلہ
ویدرکُ کلّ بأنّ الھَوی
طَوَی ما طوی من معا یبنا المترفات الأصیلة
ولم یُبقِ إلا محاسننا الفجّۃ([4]) المستحیلة

 

وھا نحنُ نعرفُ أبعادنا الشاسعة
وما امتدّ في عمقھا من خشونة
وکیف ملکنا عیوباً منوّعۃً رائعۃ
تخبّیء أو جُھھا خلف ستر الرضی واللیونة
وخلف الوداعۃ خلف السکینة
وفي لحظات الصفاء لمسنا شذانا الرصینا([5] )
وذقنا محاسننا السمحۃ المنعمة
وذاک الطِلاءٖ الذي لفّ أعماقنا المبھمة
وغطّی الحماقۃ والضعف فینا

وفي لحظات الحنین ھوینا
بساطتنا وعشقنا العذوبة
وھنا نحن نعشقُ ما تخلقُ الادمیۃ فینا
ونلمسُ أعماقنا الشاسعات الرھیبة
وما في حماقتنا من جمالِ شذٍ وخصوبة

وکنا عشقنا انبثاق الحرارۃ في مقلتینا([6])
فدعنا نحبّ النصوب([7] )
وکنا ھوینا التورّد والشعر في شفتینا
فلم لا نحبّ الشحوب([8]
ولم لا نخلّف رکناً من المقت([9] ) بین یدینا؟


وکنا عبدنا الصداقۃ بین المحاسن فینا
فدعنا نقیم أسس الحبّ والودّ بین العیوب
وأفسح مکاناً لبعض الحماقات بعضِ الذنوب
ودعنا نکنُ بشراً طافحین نفیضُ جنونا
وننضح([10]) ضحکاً ودمعاً سخینا

(1954م)

الشرح المجمل البسيط (خِصام) لنازک الملائكة

...

کارڈز میں کفالہ کی شرعی و فقہی حیثیت اور عصرِ حاضر کے مالیاتی اداروں میں اس کا عملی تطبیق

Cards are the plastic money of current era, and Kafala by means of their warranty is little much we know about. In this article we will discuss the necessity, use and framework of Kafala for the Debit & Credit cards issued by banks and financial institutes, in the light of Qur’an and Sunnah, Ijma-e-Umma and religious researchers.

Strategic Leaderships Competitiveness in Healthcare System of Pakistan

Globalization of quality services demands every country to make a robust, accessible to all and a globally competitive healthcare system. The aim of the study was to investigate the role of strategic leadership in providing competitive quality healthcare services. Accordingly, a comparative analysis of private and public sectors teaching hospitals, located at Peshawar, Khyber Pakhtunkhwa, Pakistan was carried out based on the prevailing strategic leadership framework and the quality of healthcare services. Suggestions are made to improve the quality gaps in healthcare services augmenting the strategic leadership interventions benchmarked with international standards. The quality of healthcare was measured using modified SERVQUAL (N= 1265 patients) into six dimension as tangibles (infrastructure), responsiveness, process of healthcare, administrative procedures, safety and trustworthiness and empathy. Further, the leadership framework (N= 300 hospital managers) prescribed by World Health Organization is modified and tested in the settings of hospitals of Pakistan. The data was analysed and presented using descriptive statistics, reliability analysis, Pearson Correlation analysis, t-test for independent samples, regression analysis. The results show that private hospitals (quality gap=4.88) are performing slightly better than public hospitals (quality gap= 5.87) in Peshawar based on patients’ perception but the difference is not statistically significant showing that both the sectors have quality gaps that need to overcome. Patients have not access to cost effective value of services particularly in public hospitals and even in private hospitals local people cannot afford.Further, it is found that leadership in hospitals at top and middle level need to advance the interventions as recommended by international standards in both the sectors to address the allied quality domains and to be globally competitive. The findings suggest continuous improvements using participation of patients’ feedback in the process of developing modern healthcare services with related facilities exclusively in public hospitals. Further, the value-added rewards and facilities to healthcare workforce can help to improve their responsiveness and empathetic attitude towards patients. Cost is recommended to be included as an isolated dimension of SERVQUAL instrument to measure the cost effective quality of healthcare services in the hospitals. Similar study is recommended in other cities of Pakistan to develop a homogenous healthcare system at national level.