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Optimal Experimental Designs for Single and Multiple Beta Responses

Thesis Info

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Author

Latif, Shahid

Program

PhD

Institute

National College of Business Administration and Economics

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Statistics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13729/1/Shahid_Latif_Statistics_HSR_NCBAE_2015_10.04.2017.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726813365

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Beta regression models are becoming popular in diverse fields of application because these models simultaneously model mean and variance for a variety of data. Optimal designs for these models have got little attention in literature. In this study we focus on the construction of optimal designs for fitting single and multi-response beta regression models for unrestricted and restricted design regions assuming the mean-precision parameterization of beta distribution. The optimality criteria in focus for single response models are the D- and the Ds-criterion, whereas for multi-response models the focus is D- and generalized D-criteria. Considering the form of beta regression model proposed by Ferrari and Cribari-Neto (2004), D-optimal designs are constructed for models involving one and two predictors. A visual approach to guess the locations of design points from mean function plot is suggested and applied. The robustness of constructed designs to parameter misspecification is also addressed. Optimal designs vary both in terms of number and locations of design points and are not always balanced. Ds-optimal designs for precise estimation of parameters of mean sub-model are found to be balanced saturated designs making visual assessment of the design structure easier. The structure of D-optimal designs constructed for models with two predictors varies in consonance with parameter spaces of the respective models. Contrary to single predictor models, use of the Ds-criterion for design construction does not simplify the design structure. Exploiting the general class of beta regression models of Simas et al. (2010), optimal designs are developed for models with one and two predictors. The visual approach is eloquently extended to models with single predictor for assessment of the design structure using plots of mean and precision parameters. Optimal designs for models with single predictor are compared with various standard designs to identify alternative efficient designs. The constructed designs for models with two predictors are compared with equiweighted designs including a two-factor factorial design and a few variants in search for alternatives to optimal designs for practical use. As locally optimal designs are not robust, sequentially constructed designs are presented for single predictor models as their alternative. These designs prove to be efficient regardless of the severity level of parameter misspecification and the size of the experiment. Individually Optimal Design (IOD) and Jointly Optimal Design (JOD) for multi-response beta regression models with single predictor as defined by Souza and Moura (2012a) are studied. The knowledge of shapes of mean functions and information about the structure of IODs is found to be useful in assessing the structure of JODs. When responses are independent D-optimal designs are explored for two- and three-response models. A strategy for using the generalized D-criterion to construct optimal designs for multi-response generalized linear models is suggested and is applied to construct JODs for kresponse beta regression models. Robustness of JODs with respect to varying multi-response models is examined. IODs and JODs are compared with each other and performance of standard designs relative to JODs is also evaluated. Applications of the designs constructed for models under study to real-life problems are given for each class of models.
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ہمیں معلومات سے زیادہ حکمت چاہیے

ہمیں معلومات سے زیادہ حکمت چاہیے
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز اساتذہ کرام اور میرے ہم مکتب ساتھیو!
آج مجھے جس موضوع پر لب کشائی کا موقع دیا گیا ہے وہ ہے:’’ہمیں معلومات سے زیادہ حکمت چاہیے‘‘
صدرِذی وقار!
علم ایک خزانہ ہے، ہر ایک اس خزانے سے اپنی تجوریوں کو بھرنا چاہتا ہے، علم جستجو سے حاصل ہوتا ہے ،علم کے حصول کے لیے محنت شاقہ کی ضرورت ہے، علم کی تگ و دو میں زندگیاں صرف ہو جاتی ہیں۔ معلومات حاصل کرتے کرتے ایّام زیست گزر جاتے ہیں۔ معلومات جیسی بھی ہوں جہالت کے گھٹا ٹوپ اندھیروں کا خاتمہ کر دیتی ہیں۔
جنابِ صدر!
معلومات کا خزانہ اس وقت متمتع اور کار آمد ثابت ہوتا ہے، جب اس خزانے کے صحیح مصارف معلوم ہوں، ان معلومات کے لیے صحیح استعمال سے آشنائی حاصل ہو، معلومات کے مطابق زندگی کے ڈھنگ ہر صاحب علم کی دسترس میں ہوں۔ دنیا بھر کی معلومات ہیں لیکن وہ صرف اپنی ذات کی حد تک محدود ہیں تو وہ نہ ہونے کے برابر ہیں۔
جنابِ صدر!
جب کسی کام میں حکمت شامل ہو جاتی ہے تو اس کے حسن کو دوبالا کر دیتی ہے، اس کی خوبصورتی میں اضافہ ہو جاتا ہے، اس کی دھنک کے رنگ نمایاں ہو جاتے ہیں، اس کی اہمیت دوبالا ہو جاتی ہے، اس کی شان نرالی ہو جاتی ہے۔ دانائی اور حکمت سے معمور کام انفرادیت کا حامل ہوتا ہے، اس علم صفت کے حامل طفلان خودمعا ملہ نہیں ہوتے بلکہ زیرک و فطین لوگ ہوتے ہیں۔
صدرِذی وقار!
حکمت کے پھول کاغذی پھول نہیں ہوتے، گلشن حکمت و دانائی میں چلنے والی ہوا حیات بخش جھونکوں سے معمور ہوتی ہے، جس جگہ پر حکمت ہوتی ہے...

برصغیر میں غیر مسلم اہل قلم کے بزبان اردو تراجم و تفاسیر قرآنی

Islamic literary legacy is diverse and multidimensional in Sub-continent despite its being prone to religious b and the issue of migration integral part of Islamic literary legacy is the Quranic translations & interpretations. The main aspect of these translations & interpretations are the endeavors put forward by Muslim as well as non-Muslim scholars. Keeping in view the endeavors translations & interpretations of Quran, the non-Muslims minorities of sub-continent can be divided into two groups. The first group of part is based on the followers of Judaism, Parsee, Buddhist, Sikhism, Jainism and idols of Kalash whose translations and interpretations is not well known. Whereas, the second group endure Christians, Hindus and Qadyanis. Christians and Hidus consider Quran as non-revealed. Since the style of their interpretations is based on criticism and rejection in aggressive manner. Whereas the interpretations by Qadyanis are focused on religious polarized beliefs and ideologies taking into considerations Quran as revealed. That’s why Qadyanis interpretations are not accepted in Muslim community. The criticism by non-Muslims writers has resulted in rational approach for study of Quran instead of tendency based on esteem among Muslim. This paper represents aforementioned non-Muslims services regarding Quranic Interpretations and Translations which are distinguished in Muslims Interpreters.

Antioxidant and Antimicrobial Activities of Selected Plants of Pothohar Plateau

Pothohar plateau has specific agro climatic and geographical environment which might affect the antioxidant and antimicrobial attributes of native plants. In the present study, three medicinal plants (Asphodilus tenifolius, Aerva javanica and Fagonia indica) were collected from Pothohar plateau on the basis of ethno-botanical uses. Different solvent (absolute and aqueous ethanol, absolute and aqueous methanol and absolute and aqueous acetone) extracts of all the plants obtained through different extraction techniques (Stirring, orbital shaking, sonication and reflux) were evaluated for their antioxidant activities (by 2, 2-diphenyl-1- picrylhydrazyl and superoxide radical scavenging assays, reducing power and ß-carotene linoleic acid system), antimicrobial activities (by Disc diffusion and Minimum Inhibitory Concentration assays) and phytochemical studies (total phenolic and flavonoid contents). All the plant extracts exhibited good antioxidant and antimicrobial activities. Aqueous solvent extracts showed better activities as compared to pure solvent extracts. Out of four extraction techniques, extracts obtained from sonication exhibited better activities and phytochemical constituents. In case of Asphodilus tenifolius aqueous ethanol while for Aerva javanica and Fagonia indica aqueous methanol proved to be best solvent for the extraction of bioactive compounds. High Performance Liquid Chromatography analysis also revealed the presence of phenolic acids in these plant extracts. The variation in yield, phytochemical constituents and biological activities of most of the plant extracts, with respect to solvent systems and plant species were statistically significant.