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Home > Organotin Iv Complexes of O, N, O and S, S Donor Ligands Derived from Dibasic Acids for Biological Applications

Organotin Iv Complexes of O, N, O and S, S Donor Ligands Derived from Dibasic Acids for Biological Applications

Thesis Info

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Author

Ullah, Hussain

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10711/1/Hussain%20Ullah_Chem_2018_QAU_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726829735

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Herein we reports the synthesis of new mono and diorganotin(IV) complexes of Schiff baes/hydrazones with [O, N, O] and dithiocarbamates with [S, S] donor ligands. The methodologies described herein includes; the synthesis of five versatile Schiff bases/hydrazones ligands; N'', N''-4-bis(2-hydroxybenzylidene)oxalohydrazide(H4L1), N'', N''-4-bis(2-hydroxylbenzylidene)malonohydrazide (H4L2), N′, N′-4-bis(2- hydroxybenzylidene)succinohydrazide (H4L3), N′, N′-4-bis(2-hydroxybenzylidene)glutarohydrazide (H4L4) and N′, N′-4-bis(2-hydroxybenzylidene)adipohydrazide (H4L5). Herein the thesis also embodied another series of five dithiocarbamates ligands of the types; dipotassium-2, 2-oxalylbis(hydrazine-1-carbodithioat) (K2L1), dipotassium-2, 2-malonylbis(hydrazine-1-carbodithioate) (K2L2), dipotassium2, 2''-succinylbis(hydrazine-1-carbodithioate) (K2L3), dipotassium-2, 2''-glutaroylbis(hydrazine-1-carbodithioate) (K2L4) and dipotassium-2, 2''-adipoylbis(hydrazine-1carbodithioate) (K2L5). For the synthesis of organotin(IV) complexes the reaction between Schiff bases/ hydrazone ligands with [O, N,O] donor sites, mono- and diorganotin(IV)chlorides/oxides were carried out at various reaction conditions and obtained fifty new organotin Schiff bases/hydrazone complexes. The reaction between dithiocarbamae ligands with [S, S] binding sites, mono- and diorganotin(IV)chlorides were unsuccessful and end up with desulfurized isothiocynates. The structural and coordination chemistry of ligands with O, N, O and S, S binding mode/sites and thier organotin(IV) complexes were investigated by using FT-IR and single crystallographic studies in the solid sate. The solution chemistry of these complexes was investigated through mass spectrometry and some multinuclear (1H, 13C and 119Sn) spectal studies. The results revealed that Schiff bases/hydrazones coordinate to tin through a tridentate mode using [O, N, O] binding mode. The structural analysi of single crystal by X-ray technique showed that organotincomplexes procured from hydrazone with tridentate lignads (O, N, O), mono- and diorganotin(IV) chlorides exhibited distorted octahedral (oh) and distorted trigonal bipyramidal (tbp) geometry respectively.Based on the computational studies; the trigonal bipyramidal complexes showed a Sn···O tetrel bonding/interaction in the solid state. A computational study, in combination with the quantum theory of atoms in molecules (QTAIM) shows that the Sn···O interactions involved here are purely electrostatic in nature with little covalent character and leads to a shorter Sn···O [3.480(2 Å)] inter-atomic bond distance as compare to the reported “sum of van der Waals radii (3.92 Å)”. However, these types of interaction cannot be seen in the compounds when the phenyl /butyl groups or when the methylene spacer (-CH2-) between the two-hydrazone fragments is increased replaces the methyl groups. Finally, all the complexes were screened for anticancer activities using carbopaltin as a standard drug. The diorgantotin hydrazone complexes;wheremethyl and phenyl groups are attached to tin(IV)showed reasonable activities due tosolubility problems but the dibutyltin(IV) complexes of the hydrazone [O, N, O] ligands showed excellent activities and have been used as representative sample (compounds) against various cancer cell lines (HL-60, MCF-7 and HeLa ) obtained from human being. It is assumed that the high cytotoxic activities of the dibutyl tin(IV) complexes are due to its lipophilic character and can be compared with the activity of the standard drug (carboplatin). These results might be helpful in the rational drug designing of those complexes containing the dibutyl moiety.
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پروفیسرٹومس آرنلڈ

پروفیسر آرنلڈ
پچھلے مہینے کی علمی سوانح میں دو فاضلوں کی وفات کا سانحہ خاص طور سے اہم ہے، ان میں سے ایک مغرب نژاد اور دوسرا مشرقی تھا، پہلے کو ہندوستان اور ہندوستان کے مسلمان پروفیسر آرنلڈ کے نام سے جانتے ہیں، یہ فلسفہ کے عالم ہونے کے ساتھ عربی اور اسلامیات کے بھی ماہر تھے، یہ ہندوستان آکر پہلے اسلامیہ کالج لاہور میں فلسفہ کے پروفیسر مقرر ہوئے، اور پھر بعد کو محمڈن کالج علی گڑھ میں پروفیسر ہوکر آئے اور یہیں ان کی شہرت کا ستارہ چمکا، ان کی خاص خصوصیت علم کے ساتھ ان کا حسن اخلاق تھا، وہ مشرقی علماء کے ساتھ ہمیشہ گھل مل کر رہتے، اور لاہور ہو یا علی گڑھ ہر جگہ انھوں نے اپنے رفیق علماء سے کچھ سیکھا اور ان کو کچھ سکھایا، اور خصوصیت کے ساتھ لاہور میں قاضی ظفرالدین صاحب مرحوم اور علی گڑھ میں مولانا شبلی نعمانی مرحوم کے ساتھ ان کے دوستانہ اور علمی تعلقات رہے، اور ان واقعات کا نتیجہ لاہور میں ان کی تالیف السواء السبیل فی معرفۃ العرب والدخیل اور علی گڑھ میں ان کی مشہور تصنیف دعوت اسلام ہے۔
مولانا شبلی مرحوم اور ان میں تعلقات ٹھیک استاد اور شاگرد کے تھے، مگر یہ فیصلہ مشکل ہے کہ ان میں استاد کون اور شاگرد کون تھا، مولانا نے ان سے کچھ فرنچ سیکھی تھی، اور انھوں نے ان سے عربی ، مولانا مرحوم کے سفرترکی میں سمرناتک وہی رفیقِ سفر تھے، مولانا نے اپنے سفرنامہ میں اس کا حال لکھا ہے، سفر روم والے فارسی قصیدہ میں لکھتے ہیں،
آرنلڈ آنکہ رفیق است وہم استاد مرا
استاد کے استاد سے ۱۹۲۰؁ء میں لندن میں میری ملاقات ہوئی تھی، وہ اس وقت انڈیا آفس سے متعلق تھے، مولانا مرحوم کے تعلق کے سبب سے مجھ سے بڑی محبت سے پیش...

سیرت طیبہ پر قسِیس زکریا بطرس کی تنقیدات کا تجزیاتی مطالعہ

The Critiques of Zakaria Boutros on the Noble Seerah of the Holy Prophet Muhammad: An Analytical Study Islam is not only a true divine religion but an all-embracing way of life. Prophet Muhammadﷺ is the perfect and ideal role model for the whole mankind. Hisﷺ holy life is open to all in each and every aspect. Hisﷺ noble footsteps and teachings give complete guidance in every walk of life. It has been observed that Jews and Christians’ religious scholars and Orientalist study the Quran, Hadῑth, Islamic History, Culture and Civilization, generally, to deduce negative and subjective conclusions, pretending that they are studying objectively. Father Zakaria Boutros is one such priest from the Middle East. Basically, he is an Egyptian Coptic priest and an active Evangelist. He is a controversial figure in that country for his scriptural studies of Islamic texts. For the last sixty years, he has misguided hundreds of people especially Muslims through his missionary activities and maligning campaign against Islam in the form of booklets, Television programs, Internet services such as Paltalk and personal official websites etc. He has tried to distort facts and to present Prophet Muhammadﷺ in such a way that the attraction of Islam be decreased in the eyes of non-Muslims and doubts be produced among the simple-minded Muslims. In the article under reference, some selected critiques and objections on Prophet Muhammad (ﷺ) related to the birth period (pregnancy duration), lineage, sources of knowledge and accusation of worshipping the black stone, are thoroughly analyzed and responded in a scholarly way.

Computation Elimination Algorithms for Correlation Based Fast Template Matching

Template matching is frequently used in Digital Image Processing, Machine Vision, Remote Sensing and Pattern Recognition, and a large number of template matching algorithms have been proposed in literature. The performance of these algorithms may be evaluated from the perspective of accuracy as well as computational complex- ity. Algorithm designers face a tradeoff between these two desirable characteristics; often, fast algorithms lack robustness and robust algorithms are computationally ex- pensive. The basic problem we have addressed in this thesis is to develop fast as well as robust template matching algorithms. From the accuracy perspective, we choose correlation coefficient to be the match measure because it is robust to linear intensity varia- tions often encountered in practical problems. To ensure computational efficiency, we choose bound based computation elimination approaches because they allow high speed up without compromising accuracy. Most existing elimination algorithms are based on simple match metrics such as Sum of Squared Differences and Sum of Ab- solute Differences. For correlation coefficient, which is a more robust match measure, very limited efforts have been done to develop efficient elimination schemes. The main contribution of this thesis is the development of two different categories of bound based computation elimination algorithms for correlation coefficient based fast template matching. We have named the algorithms in the first category as Transitive Elimination Algorithms (Mahmood and Khan, 2007b, 2008, 2010), because these are based on transitive bounds on correlation coefficient. In these algorithms, before computing correlation coefficient, we compute bounds from neighboring search locations based on transitivity. The locations where upper bounds are less than the current known maximum are skipped from computations, as they can never become the best match location. As the percentage of skipped search locations increases, the template matching process becomes faster. Empirically, we have demonstrated speedups of up to an order of magnitude compared to existing fast algorithms without compromising accuracy. The overall speedup depends on the tightness of transitive bounds, which in turn is dependent on the strength of autocorrelation between nearby locations. Although high autocorrelation, required for efficiency of transitive algorithms, is present in many template matching applications, it may not be guaranteed in gen- eral. We have developed a second category of bound based computation elimination algorithms, which are more generic and do not require specific image statistics, such as high autocorrelation. We have named this category as Partial Correlation Elimina- tion algorithms (Mahmood and Khan, 2007a, 2011). These algorithms are based on a monotonic formulation of correlation coefficient. In this formulation, at a particular search location, correlation coefficient monotonically decreases as consecutive pixels are processed. As soon as the value of partial correlation becomes less than the cur- rent known maximum, the remaining computations are skipped. If a high magnitude maximum is found at the start of the search process, the amount of skipped compu- tations significantly increases, resulting in high speed up of the template matching process. In order to locate a high maximum at the start of search process, we have developed novel initialization schemes which are effective for small and medium sized templates. For commonly used template sizes, we have demonstrated that PCE al- gorithms out-perform existing algorithms by a significant margin. Beyond the main contribution of developing elimination algorithms for correlation, two extensions of the basic theme of this thesis have also been explored. The first direction is to extend elimination schemes for object detection. To this end, we have shown that the detection phase of an AdaBoost based edge corner detector (Mahmood, 2007; Mahmood and Khan, 2009) can be significantly speeded up by adapting elimination strategies to this problem. In the second direction we prove that in video encoders, if motion estimation is done by maximization of correlation coefficient and motion compensation is done by first order linear estimation, the vari- ance of the residue signal will always be less than the existing motion compensation schemes (Mahmood et al., 2007). This result may potentially be used to increase compression of video signal as compared to the current techniques. The fast corre- lation strategies, proposed in this thesis, may be coupled with this result to develop correlation-based video encoders, having low computational cost.