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Organotin Iv Complexes With O’O Donor Atoms from Carboxylic Acid Derivatives

Thesis Info

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Author

Muhammad, Niaz

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1184

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726830482

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In the present study, a series of tri- and diorganotin(IV) carboxylates have been synthe sized by the reaction of tri- and diorganotin(IV) chlorides/oxides with substituted phenylethanoic acids/salts and α-alkyl cinnamic acids/salts in dry toluene under reflux condition for 8-10 h. The ligands used were 4-Methoxyphenylethanoic acid (HL 1 ), 4- Nitrophenylethanoic acid (HL 2 ), 4-Chlorophenylethanoic acid (HL 3 ), 3-Methylphenyl ethanoic acid (HL 4 ), 3-(4-Bromophenyl)-2-ethylacrylic acid (HL 5 ), 3-(4-Bromophenyl) -2-methylacrylic acid (HL 6 ), 3-(4-Chlorophenyl)-2-methylacrylic acid (HL 7 ), 3-(4- Chlorophenyl)-2-ethylacrylic acid (HL 8 ), 3-(4-Nitrophenyl)-2-methylacrylic acid (HL 9 ) and 3-(4-Nitrophenyl)-2-ethylacrylic acid (HL 10 ). The composition, coordination mode of ligands, structural confirmation and geometry assignment of the complexes in solid and in solution states were made by different analytical techniques such as elemental analysis, FT-IR, multinuclear ( 1 H, 13 C and 119 Sn) NMR, mass spectrometry and X-ray single crystal analysis. Based on these results, the ligand appeared to coordinate the Sn atom via COO moiety. The triorganotin(IV) derivatives demonstrate polymeric trigonal bipyramidal geometry in solid state and a monomeric tetrahedral structure in solution. The diorganotin(IV) dicarboxylates have shown a distorted octahedral or skew- trapezoidal geometry in solid state, however, the coordination around Sn change from six to five in solution, in most cases. The interaction of (n-C 4 H 9 ) 3 Sn(IV)L, (CH 3 ) 3 Sn(IV)L, (n-C 4 H 9 ) 2 (IV)SnL 2 and (C 2 H 5 ) 2 Sn(IV)L 2 (where L = 4-nitrophenylethanoate) with DNA was investigated by cyclic voltammetry (CV). The positive peak potential shift in CV evidenced intercalative mode of interaction of these complexes with DNA. The CV results revealed the following increasing order of binding strength: (C 2 H 5 ) 2 Sn(IV)L 2 (8.5 x 10 3 ) < (n-C 4 H 9 ) 2 Sn(IV)L 2 (1.11 x 10 4 ) < (CH 3 ) 3 Sn(IV)L (1.39 x 10 4 ) < (n- C 4 H 9 ) 3 Sn(IV)L (1.46 x 10 4 ) M -1 . The negative values of ∆G designate the spontaneity of complex-DNA binding. Most of the synthesized complexes were screened for their antibacterial and antifungal activities against various medically important bacteria and fungi. The triorganotin(IV) derivatives have strong bactericidal and fungicidal action than diorganotin(IV) complexes with few exceptions. Some of the compounds were found to have antimicrobial activity comparable or even more than reference drugs and may be used as drugs in future. Some complexes have shown higher cytotoxicity(against iiBrine shrimp) than standard drug while only compound 10 was found stronger anticancer agent against human prostate cell lines(PC-3).

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مولانا ماہر القادری

ماہر القادری
افسوس ہے گذشتہ مئی کی ۱۰تاریخ کو اردو زبان کے نامور شاعر،ادیب اور نقاد جناب ماہرالقادری صاحب کا ۷۲برس کی عمر میں انتقال ہوگیا۔جدہ میں کوئی بڑامشاعرہ تھا،اُس میں شرکت کے لیے گئے تھے۔بہت رات گئے مشاعرہ میں اپناکلام سنایا، داد و تحسین سے محفل گونج اٹھی۔اُس سے فارغ ہوکر ابھی قیام گاہ پر آئے ہی تھے کہ اچانک سینہ میں درد اٹھا اور طبی امداد کے پہنچتے پہنچتے روح قفس عنصری سے پرواز کرگئی۔اناﷲ واناالیہ راجعون۔تدفین مکہ مکرمہ کے مشہور قبرستان جنت المعلی میں ہوئی۔
مرحوم کااصل نام منظور حسین تھا، بلند شہر میں پیداہوئے تھے، تقسیم سے پہلے ہی اردو کے نامور شعراء میں شمار ہونے لگے تھے لیکن اس زمانہ میں وہ صرف حسن وشباب کے شاعرتھے، نظم سے زیادہ اُن کی غزلیں پُرکیف ووجد آفرین ہوتی تھیں، نظم میں اُن کا نعتیہ کلام اورسلام بڑے معرکے کا تھا جس سے اُن کی شہرت گھر گھر پہنچی۔ تقسیم کے بعدکراچی چلے گئے۔طبیعت کے شروع سے نیک اور دین دار تھے، پاکستان میں جماعت اسلامی کے زیر اثر آجانے سے اُن کی زندگی میں انقلاب عظیم آگیا۔اُن کاماہنامہ ’فاران‘ جماعت کاآرگن ہونے کے ساتھ ایک بلند پایہ ادبی مجلہ بھی تھا،اس میں مرحوم کے قلم سے لکھے ہوئے تنقیدی مضامین زبان وبیان کے اصول وقواعد اوران کے رموز ونکات کے نقطۂ نظر سے پڑھنے کے لائق ہوتے تھے۔اُن کی نثر ونظم کے متعدد مجموعے شائع ہوکر مقبول عوام وخواص ہوچکے ہیں۔برہان اوراس کے ادارے سے انھیں قلبی تعلق اورلگاؤ تھا۔گذشہ سفرنامۂ پاکستان میں انھوں نے اپنا تذکرہ پڑھا توفوراً ایک محبت بھرا خط لکھا جس میں سفر نامہ کے حسن انشااورطرزبیاں کی دل کھول کرداد دی اورساتھ ہی ایک تازہ نعت بھی بھیجی جواُسی زمانہ میں برہان میں شائع ہوگئی تھی۔
جنت المعلی کی سرزمین کاکیا کہنا!ظاہر ھاحسنۃ وباطنھا حسنہ،سبحان اﷲ!نور ہی...

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