Search or add a thesis

Advanced Search (Beta)
Home > Pharmacokinetic Evaluation of Amoxicillin/Clavulanicacid and Antacid Interaction

Pharmacokinetic Evaluation of Amoxicillin/Clavulanicacid and Antacid Interaction

Thesis Info

Access Option

External Link

Author

Fatima, Anab

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Applied Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/8832/1/Anab%20Fatima%20Pharmaceutics%20UOK%20final%20Thesis%20pdf.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726871786

Similar


Every day various Pharmaceutical products being marketed by various Pharmaceutical companies and various problems arises after the product gets approved and marketed.As coprescription of various drugs is a common practice of health care practitioners in our country resulting in significant drug-drug interactions in local population and are very much challenging because one drug may alter bioavailability of any of the other drug at its receptor site. Mostly they resulted due to any significant change in ADME(absorption,distribution,metabolism and elimination).These interactions lead to serious adverse effects and sometimes lead to death.Some other factors like self-medication,lack of professional pharmacist at pharmacy, racial and ethnic differences contribute to development of ADRs(Adverse drug reactions).It also increase professional liability of Pharmacist that by knowledge of pharmacokinetic tools they point out various drug-drug interactions and provide appropriate guide line for better pharmacotherapy. Drug-drug interaction study can be analyzed by various pre-clinical and clinical experimental ways.The present study mainly focused on compartmental and non-compartmental method of analysis.In this method pharmacokinetic drug-drug interaction analyze followed by statistical comparision of some parameters.It is relatively a simple and rapid method.If most of pharmacokinetic parameters analyzed showed a significant statistical difference demonstrate the manifestation of drug-drug interaction. During the present study pharmacokinetic interaction between oral combination of amino penicillin and a beta-lactamase inhibitor i.e. Co-amoxiclav(250 mg amoxicillin + 125 mg clavulanic acid) with an antacid(10 ml) containing aluminium hydroxide,magnesium hydroxide and simethicone were evaluated.As it is most common practice of using this combination in local population not only prescribed but also as self medication.The data obtained was used to compare pharmacokinetic parameters of Co-amoxiclave alone and with simultaneous administration of antacid.Initially Physico-chemical test were performed for augmentin to check the quality of product.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

پروفیسرمحمد الیاس برنی

پروفیسر محمد الیاس برنی
افسوس ہے کہ گذشتہ مہینوں میں دنیائے علم و ادب کی دو نامور شخصیتیں پروفیسر محمد الیاس برنی اور خلیفہ عبدالحکیم ہم سے جدا ہوگئے، پروفیسر الیاس برنی علی گڑھ کالج کے نامور فرزند تھے، حصول تعلیم کے بعد کالج ہی میں معاشیات کے لکچرار ہوگئے تھے، پھر دارالترجمہ کے رکن کی حیثیت سے حیدرآباد چلے گئے اور کچھ دنوں تک اس کے ناظم بھی رہے، پھر جامعہ عثمانیہ میں معاشیات کے استاد مقرر ہوگئے، اور اسی عہدہ سے سبکدوش ہوئے، تعلیم و تدریس کے ساتھ تالیف و تصنیف کا سلسلہ بھی برابر جاری رہا، جامعہ عثمانیہ کے لیے معاشیات کی کئی کتابیں لکھیں، اس فن کو اردو میں سب سے پہلے ان ہی نے روشناس کیا تھا، ان کی پہلی تصنیف علم المعیشت ایک زمانہ میں بہت مشہور تھی۔ شعر و ادب کا مذاق بھی رکھتے تھے، معارف ملت، جذبات فطرت اور مناظر قدرت کے نام سے کئی حصوں میں اردو نظموں کا ایک نہایت عمدہ انتخاب مرتب کیا تھا جو بہت مقبول ہوا۔
مذہبی ذوق ابتداء سے تھا جو عمر کے ساتھ بڑھتا گیا اور آخر میں مذہب و تصوف کا بڑا غلبہ ہوگیا تھا اور ان کی ساری قلمی کوششیں اسی کے لیے وقف ہوگئی تھیں، انھوں نے مختلف مذہبی موضوعات پر مفید کتابیں لکھیں، ان کا سفرنامۂ حج، صراط الحمید خاص طور پر مقبول ہوا، قادیانی مذہب کے نام سے ایک ضخیم کتاب لکھی تھی جس میں مرزا غلام احمد قادیانی اور دوسرے قادیانی اکابر کی تحریروں سے اس مذہب کی حقیقت ظاہر کی گئی تھی، یہ کتاب اتنی مقبول ہوئی کہ اس کے کئی ایڈیشن شائع ہوئے اور ہر ایڈیشن پہلے ایڈیشن سے بڑھ کر تھا، ان کی چھوٹی بڑی تصانیف کی تعداد دو درجن سے زیادہ ہوگی، اﷲ تعالیٰ اس شیدائے علم و دین کو اپنی رحمت...

طلب معاش کی اہمیت اور اس کی ترقی کے اسباب قرآن اور سنت کی روشنی میں

Trade has been considered as the most important mode of caring livelihood.  Trade is considered as sole biggest medium because all other modes carry secondary position, as they all derive from trade in one way or the other. That’s way crafts and services have gained much success in this era of machinery and technology. In spite of all this trade assumes the same highest positions in this era too. Islam has not left trade on its own but has framed principles. These principles are not only helpful on individual scale but they give benefits to whole community. It benefits in this world and hereafter of its users. Islam is an eternal religion, so it addresses all problems of this era and of upcoming in its teachings. We can gain both worldly and hereafter benefits by acting upon Islamic principles. We have glorious examples of past traders who visited the whole world in order to carry trade. They trade far and wide on the basis of Islamic principles. They not only maintained their businesses, but also preached Islam through their just dealings and humble behavior. Their customers or the people who come into their contact were so impressed that they not only became Muslims but also changed their traditions, Customs, culture and even languages. This article discusses the reasons that explicate the beauty of Trade.

Implications of the Socio-Cultural Milieu of the Society on Male Reproductive Health Behaviour in Punjab-Pakistan

Introduction: In Pakistan, male involvement in reproductive health started long before the concept of a holistic approach emerged from ICPD in 1994. Men are far behind the knowledge about contraceptives, authority of decisions making, religiosity, exposure of media, health attitude, physical cost, Knowledge of HIV/STDs, drugs and family planning services. These circumstances have damaging-effect on men''s reproductive health as well. The poor reproductive health of men in the entire Pakistan has been reported in many studies. The different national and international agencies have shown a great concern on this alarming situation of men''s deteriorating reproductive health status. They have recommended to investigate the men reproductive health status in relation to different aspects. In this context the main objectives of this study is to identify and analyze different types of socio-cultural characteristics, affect the attitudes, lack of awareness of respondents toward reproductive health behaviour were examioned in Punjab-Pakistan. Methodology: A cross sectional study was conducted in 3-districts of Punjab province. One tehsils from each district selected randomly and sample of 272 men from Tehsil-1 i.e. Rawalpindi, 197 from Tehsil-2 i.e. Bahawalpur and 131 from Tehsil-3 i.e. Toba Tek Singh. From each Tehsil equal no. of respondents was selected from rural and urban areas by random sampling technique to explore the research objectives. In this way the total sample size will be 600. 300 from rural and 300 from urban areas. A well-structured questionnaire consisting of open ended and close ended questions has been prepared in the light of research objectives. Pre-testing was also in the study plan to examine the work-ability of questionnaire and to know the sensitive issues which can be tackled intelligently. Results: Bi-variate and multivariate analyses were used to explore the relationship between different terms MRHB. The results regarding age, age at marriage, duration of marriage, communication with wife, fertility preference, discussion about reproductive health problems, general health status, Knowledge about Contraceptive, Contraceptive use behaviour, knowledge about HIV/STDs of the respondents and their reproductive health behaviour were having there strong relationship and communication of affairs with wife having no relation and in multivariate analysis were used to build model and respondents age at marriage, duration of marriage, education, income, communication with wives, drugs using were highly significant and age of the respondent, communication of affairs, ideal number of children in a family were non-significant with MRHB.. The value of adjusting R 2 is 0.660 and it indicates that about 66% variation in the dependent variable is explained by knowledge about contraceptive and use of contraceptive, communication with wives, drug use, reproductive health problems, general health, knowledge about HIV, Media exposure. Recommendations: Based on the research findings it is suggested that a general acceptance of contraceptive use, men along with women should be include in the target group as most of the decisions regarding family planning and contraception necessitate prior approval of male partners. Men shall be educate to give women all due rights especially their reproductive rights and involve them in reproductive and contraceptive decision making. Awareness should be created amongst male to give their women freedom of expression and let them join paid jobs, thereby making the family economically prosperous. Perceptions of the respondents were clear about family planning, awareness should be created against religious misconceptions and make it more convenient for the illiterates in the form of a packages deal. It would be more appropriate to tackle family planning campaign in the light of baby care and mother health along with strongly advocating improvement of economic conditions of the family. All income groups should be convinced to use contraceptives as an effective tool for family planning, more stress should be given on low and medium income groups, discourage the preferential gender treatment and involved their wives in all family matters. Primary health center (PHC) programs must be geared to meet men’s needs. Communication between spouses about RH should be developed through awareness. PHC service providers are mostly female, males should be inducted.