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Pharmacological Screening of Different Extracts of Tribulus Terrestris for Neurodegenerative Disorders and Other Potential Activities

Thesis Info

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Author

Chaudhary, Zunera

Program

PhD

Institute

Government College University

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2020

Thesis Completion Status

Completed

Subject

Pharmacology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/14693/1/zunera%20chauhdary%20pharmacy%202020%20gcuf%20prr.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726880339

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Oxidative stress is predominantly involved in pathogenesis of neurodegeneration. Conventional treatments are linked to harmful after-effects. Revolutionary herbal therapeutic agents are unmet clinical need to target neurodegeneration. Steroidal saponins, alkaloid and flavonoids are key phytochemicals of Tribulus terrestris (T. terrestris) accountable for its neuroprotective medicinal peculiarity. The objective of current study was to ensure the safety and to explore neuroprotective potential of T. terrestris. Physicochemical, phytochemical and GCMS analyses were carried out for characterization of plant. Acute toxicity, sub-acute toxicity and in vitro antioxidant activity were investigated. We measured the effect of T. terrestris methanol extract in aluminum chloride induced Alzheimer’s disease model and haloperidol induced parkinsonian rats by estimating behavioral and biochemical parameters. Open field test for locomotion and exploration, passive avoidance task for learning and memory, Y-maze and elevated plus maze for spontaneous behavior, memory and anxiety , hole board test for exploratory behavior and wire hanging test for neuromuscular coordination estimation were performed in anti-Alzheimer study. Catalepsy, head dipping, ladder climbing, foot printing and wire hanging behavioral task were carried out in anti-Parkinson’s study. The level of antioxidant enzymes and acetylcholinesterase inhibitory activity were estimated on brain homogenates of both neuroprotective studies. mRNA expression of pathological biomarkers was evaluated by RTPCR. GC-MS analysis showed highest % peak area (64.19) of benzene dicarboxylic acid. Toxicity signs and mortality were not observed during toxicity studies. TTME exhibited antioxidant properties by DPPH scavenging and by reduction potential. The results showed that TTME at a dose of 1000 mg/kg significantly improved (p ˂ 0.05) aluminum chloride, haloperidol induced neurotoxicity by modulating motor dysfunctions and cognitive disabilities, normalized the biochemical alteration of antioxidant enzymes and acetylcholinesterase. Histopathological analysis revealed that TTME significantly reversed the degenerative changes, neurofibrillary tangles, neuroinflmmation and neuronal loss in the brain architecture. TTME significantly downregulated (p ˂ 0.001) the level of BACE-1, IL-1α, IL-1β, TNFα and alpha synuclein mRNA expression. We concluded that Tribulus terrestris improved behavioral and biochemical parameters and therefore it will be effective in treatment of neurodegenerative disorders via myriad underlying mechanistic pathways.
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کتاب اور صاحب ِکتاب کی نظر

کتاب اور صاحبِ کتاب کی نذر
لعل و گوہر سے گِراں تر اُن کی یہ تحریر ہے
ہے یہی تخت شہی ، اُن کی یہی جاگیر ہے
علم سے بڑھ کر کوئی بھی نعمتِ کبریٰ نہیں
علم طاقت، علم دولت، علم ہی شمشیر ہے
اِس میں غوطہ زن تمہیں ہونا ہے میرے دوستو
وقت کا جو خواب ہے اُس کی یہی تعبیر ہے
اختصار و جامعیت کی مرقعّ ہے یہی
بند کوزے میں سمندر ، ان کی ہر تقریر ہے
کس قدر گہری نظر ہے اِن کی سب حالات پر
وقت کے نباض کی منہ بولتی تصویر ہے
چار گوشہ اُن کی شخصیت ہے خود ہی دیکھ لو
اِک مدرس، ایک عالم ہے ،خطیب اور پیر ہے
ظلمتِ شب میں فروزاں نور کا مینار ہیں
سَیف ہے اُن کی زباں ، ہر لفظ میں تاثیر ہے
اک خزینۂ گراں مایہ ہے اُن کی پیشکش
ہر مدرس ، ہر مقرر کے لیے اکسیر ہے
حضرت راشد ؔ کی کاوش مرحبا ، صد مرحبا
اِن کا اِک اِک حرف تائبؔ نعرۂ تکبیر ہے
پروفیسر اکرام تائب
سابق صدر شعبہ (اردو ادبیات)
گورنمنٹ پوسٹ گریجوایٹ کالج عارف والا

Peningkatan Hasil Belajar Pendidikan Agama Islam Siswa Kelas XI Di SMA Ekasakti Padang Dengan Metode Pembelajaran Demonstration Berbasis Discussion Process

Penelitian ini bertujuan untuk mengetahui peningkatan keaktifan dan hasil belajar siswa pada mata pelajaran Pendidikan Agama Islam (PAI) setelah diterapkannya metode pembelajaran demonstration berbasis discussion process. Metode penelitian yang digunakan dalam penelitian ini adalah Penelitian Tindakan Kelas (PTK). Penelitian dilakukan di SMA EKASAKTI Padang pada kelas XI. Metode pengumpulan data yang dilakukan pada penelitian ini adalah: observasi, wawancara,   dokumentasi, dan tes. Analisis  data  dalam  penelitian  ini  dilakukan  secara deskriptif  kuantitatif  dan kualitatif. Hasil dari penelitian ini adalah: (1). Kesiapan siswa dalam menerima pelajaran  sebelum  dilakukan  tindakan  39, 06%,   setelah siklus  I 70, 31%, dan setelah siklus II 86, 23%. (2). Keaktifan siswa dalam proses pembelajaran sebelum dilakukan tindakan 23, 18%, setelah siklus I 67, 97%, dan setelah siklus II 85, 41%. (3). Persentase siswa yang mendapatkan nilai tuntas di atas 70 sebelum dilakukan tindakan 31, 75%, setelah siklus I 68, 25%, dan setelah siklus II 87, 75%. (4). Terdapat peningkatan yang signifikan antara masing-masing indikator pada setiap siklus, hal tersebut dapat di lihat  dari  peningkatan  kesiapan,   keaktifan,   dan  hasil  belajar  siswa  pada  saat sebelum dilakukan tindakan, pada siklus I dan pada siklus II. Pada siklus II semua indikator telah melampaui target persentase indikator keberhasilan yang telah ditetapkan.  Sehingga  siklus  penelitian dapat  dihentikan  pada  siklus  II dan dapat di tarik kesimpulan bahwa metode pembelajaran demonstration berbasis  discussion process berhasil serta lebih efektif dibandingkan dengan metode ceramah.

Flood Risk Modelling and Management in Panjkora Basin, Eastern Hindu Kush, Pakistan

This study deals with the flood risk modeling and management in Panjkora river Basin, eastern Hindu Kush, Pakistan. The magnitude and frequency of disastrous floods have been increased during the past two decades mainly due to increasing intensity of rainfall recurrences, excessive melting of snow and glaciers in the upper catchment areas and hydrological response of the basin to extreme rainfall event. The geo-morphometric characteristics and unplanned anthropogenic activities particularly deforestation and encroachment onto the river channel have further intensified both flash and riverine flood events, and destructive to socio-economic and infrastructure sectors. To achieve the study objectives, geo-morphometric characteristics, hydrometeorological parameters (rainfall, surface runoff and discharge), infrastructure, land cover and socio-economic conditions were analysed. Geo-morphometric ranking model, Natural Resource Conservation Service (NRCS) hydrological model, Hydrologic Engineering Centre River Analysis System (HEC-RAS) and Hydrologic Engineering Centre’s Geographic River Analysis System (HEC-GeoRAS) spatial hydrological models in integration with Geographic Information System (GIS), remote sensing and Global Positioning System (GPS) were used to estimate and geo-visualize flood risk. Parallel to this, a new approach of flood susceptibility modeling has been generated and applied.In this study, geo-morphometric ranking model has been applied to geo-visualize the spatial pattern of areas exposed to flood hazard in Panjkora Basin. In the study area, the estimated geographical area dominated by flash flood characteristics is 5345 Km2 (90.5%), whereas the remaining 560 Km2 (9.5%) has riverine flood characteristics. The degree of flash flood susceptibility calculated by integrating the outputs of geomorphometric ranking model and NRCS hydrological model in GIS environment. The spatial pattern offlash flood susceptibility has been categorized into very high, high, moderate, low to very low susceptibility zones, and spread over 27% (1441Km2), 36.5% (1950Km2), 23.4% (1252Km2), 11.3% (604Km2) and 1.8% (98Km2) of the geographical area of Panjkora Basin, respectively. The analysis revealed that the flood susceptibility increases with increase in geo-morphometric ranking number and surface runoff. In addition, Gumbel’s frequency distribution approach is used to analyze the instantaneous daily peak discharge maxima of the past 32 years. The hydrological and ix hydraulic data were entered as input parameters to quantify and geo-visualize the vertical profile and spatial extent of floods in the riverine zone of Panjkora River using HECRAS and HEC-GeoRAS in integration with GIS. The estimated magnitude of 200-years flood peak is 1392m3/sec having potential to inundate an area of 45.5km2 with maximum depth of more than 19m. Such nature of flood has potential to cause damages to 46 km road along river, 16 bridges, 46 culverts, 20.2 Km2 agricultural land and 10.4 Km2 builtup area in the riverine flood hazard zone. The average depth levels of 10-year, 25, 100, 150 and 200-year flood return are 2.7-meter, 3.5, 5.8, 7.2 and 9.3-m, whereas, average probable spatial extents of these floods are 1422-meter, 1490-m, 1840-m, 1980-m and 2600-m, respectively. Similarly, these floods can cause potential damages with estimated economic losses of 557.4million PKR, 955.3, 1981.2, 2689, 4420.5 and 6174million PKR, respectively. It was found from the analysis that in addition to other sectors human lives and infrastructure is at high risk in Panjkora Basin.The study has a strength and provides guidelines for disaster managers and decision-makers in devising location specific effective flood risk reduction strategies in the region. It was found that in the study area flood risk management requires integrated approach of flood risk modeling, flood forecasting, early warning system and flood combating system. This study has proposed flood risk management plan comprised of flood zone specific structural measures including suitable sites for multi-purpose dam, check dams, bio-check dams, protective walls, guided head spurs and bio-engineering measures, whereas non-structural measures includes installation of weather RADAR, automatic hydro-gauging stations and sensor based met stations are specifically recommended based on genesis and impact of floods.