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Phytochemical and Biological Studies on Viburnum Grandiflorum

Thesis Info

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Author

Muhammad Alam

Program

PhD

Institute

University of Peshawar

City

Peshawar

Province

KPK

Country

Pakistan

Thesis Completing Year

2014

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/884

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676726916520

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This dissertation consists of phytochemical and biological studies of the medicinal plant Viburnum grandiflorum, which has been investigated for the first time for their phytochemical constituents. Three new compounds; grandino 5, 8 peroxide (259), grandinoid (263), grandifloruside (266) from the aerial parts and three compounds; viburnoside (268), grandiflorinol (274) and grandifloronin (275) isolated from the roots of V.grandiflorum. Ten hitherto unreported compounds; betulinic acid (257), ursolic acid (107), β- sitosterol (258), oleanolic acid (138), stigmasterol (260), β-sitosterol 3-O- β-D- glucopyranoside (261), benzofuran derivative (262), betulin (264), p-hydroxy cinnamic acid (229), 3, 4, 5-trihydroxy benzoic acid; 3,5 dimethyl ether 4-O-β-D- glucopyranoside (265) from the aerial parts while six compounds; ethyl gallate (267), pentadecyl 3, 4-dihydroxy butanoate (269), cedrusin (270), koaburaside (271), (+) syringaresinol (272) and secoisolariciresinol (273) were isolated from roots of V. grandiflorum. A cerimide class compound viburnoside (268), has reported first time from this genus. Advanced and sophisticated spectroscopic techniques were used for the characterization of compounds i.e. EI-MS, ESI-MS, UV, IR, 1H NMR, 13 C NMR (BB and DEPT), HMBC, HSQC, NOESY, COSY and TOCSY. The crude ethanolic extracts, fractions and pure compounds were evaluated for their biological potentials. The crude ethanolic extracts and subsequent fractions (aerial parts and roots) showed significant antibacterial activity and exhibited moderate antifungal activity, while oils from the aerial parts found effective against A. flavus and M. canis. The fractions and oils (aerial parts) investigated for their phytotoxic activity which indicated significant phytotoxic activity except n-hexane fraction of aerial parts and ethyl acetate fraction of roots at low dose, while both samples of oils showed good phytotoxic activity. All fractions of aerial parts and roots exhibited significant insecticidal activity against the R. dominica, and C. analis except n-hexane fraction of roots. Both the tested oil samples showed moderate antileishmanicidal activity. The xanthine oxidase inhibition effect of the tested compound 262 was found moderate against the positive control (Allupurinol). The crude ethanolic extract (aerial parts) and compound 270 tested for their antinociceptive properties, anti-inflammatory effects, anti-inflammatory effects, sedative effect, muscle relaxant effect and anticonvulsant effects and found active in the antinociceptive activity, moderate anti-inflammatory and antipyretic effects. Both samples showed mild muscle relaxant effects. It is concluded that roots and aerial parts of V. grandiflorum can be safely used as antifungal especially against M. canis and Fusarium species. Beside the antifungal action the plant is a potential source of insects and weeds control. The roots of V. grandiflorum can also be used safely for the treatment of pain and inflammation.
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سیماب ؔاکبر آبادی

جناب سیماب ؔاکبر آبادی
افسوس ہے کہ ہندوستان کے نامور شاعر جناب سیماب اکبر آبادی نے جو کچھ دنوں سے فالج میں مبتلا تھے، ۳۱؍ جنوری کو کراچی میں انتقال کیا، وہ داغ کی یادگار صاحبِ طرز اور موجودہ دور کے اساتذہ میں تھے۔
ان کے شاگردوں کا دائرہ بہت وسیع اور ان کا ایک خاص حلقہ تھا، انہوں نے اپنے رسالہ شاعر آگرہ کے ذریعہ اردو ادب و شاعری کی بڑی خدمت انجام دی، اور ہندوستان کے ان حصوں میں بھی جہاں شاعری کا چرچا کم تھا اس کا مذاق پیدا کردیا، اس لیے ان کی موت تنہا ایک شاعر کی نہیں، بلکہ ایک محسنِ ادب اور خدمت گذار اردو کی موت ہے، اﷲ تعالیٰ انکو اپنی رحمت و مغفرت کی داد و تحسین سے نوازے۔
(شاہ معین الدین ندوی، فروری ۱۹۵۱ء)

 

خرید و فروخت کے شرعی احکامات، عصرِ حاضر میں اطلاق کی صورتیں: سیرت طیبہ کی روشنی میں

Transactions are part of social life. Sale and purchase are important activities of human life. Islam gives guidance for sale and purchase transactions and the life. Jurists and ulma have addressed the varieties of such transactions as the world became increasingly complex place. This article discuss the basic type of sale and purchase and is being used in Islamic banking system.

Socio-Economic and Cultural Determinants of Attitude Towards Reproductive Health Rights in Punjab, Pakistan

Women’s health status is affected by complex biological, social and cultural factors, which are interrelated and only can be addressed in a comprehensive manner. Reproductive health is determined not only by the quality and availability of health care, but also by socio-economic development levels, lifestyles and women’s position in society. Women health is compromised not by lack of medical knowledge, but by infringement on women’s human rights including reproductive health rights. Poor women, who lack adequate food, basic health care, or modern contraception, suffer grave consequences for reproductive health. A woman who is malnourished and in poor health runs much greater risks in reproductive health issues and usually suffers without proper treatment and dies in most of cases. The negative consequences of denying RHR extend beyond women’s reproductive health to their overall health, the welfare of their children, and even the economic and social fabric of nations. This thesis presents a study of socio-economic and cultural determinants of attitude towards reproductive health rights in Punjab, Pakistan. The immediate objective of the study was to ascertain the socio-economic and cultural characteristics of the respondent’s attitude towards reproductive health rights which have affect on married women’s knowledge about reproductive health rights and their attitude towards the practices of RHR to maintain their health and to meet their reproductive health need and to investigate the relationship between respondent’s socio cultural factors and their attitude towards reproductive health rights. A cross-sectional study was conducted with 700 married women having at least one child in three districts; Toba-Tek Singh, Bahawalpur, and Rawalpindi of Punjab province, Pakistan. In addition, focus group discussions were also carried out for detailed qualitative information on the issue. After editing and cleaning, a three-fold analysis, at uni-variate, bi-variate and multi-variate levels, of coded data, was undertaken. The main findings at bi-variate level analysis show a significant relationship between all socio-economic and cultural factors (i.e. monthly income, gender role, women’s economic status, inter-spousal communication, mobility, decision making, awareness about HIV/AIDS, modernity, life style aspiration) and the married women’s attitudes towards the acquisition of knowledge and the practice of RHR to maintain their reproductive health rights. Multi-variate analysis showed that the most important and contributing socio-economic factors in explaining married women’s’ attitudes towards the practice of RHR were; monthly income, women’s economic status (currently paid employment), women’s communication with her husband, and women’s decision making power. Therefore, it was concluded on the basis of multi-variate analysis that socio- economic and cultural factors were more important than structural/ environmental and programmatic factors in making women’s attitude positive and more consistent for practicing RHR in Pakistan. From the focus groups discussions it was found that there was a lack of inter-spousal communication particularly over the issue of adoption and practice of RHR. Generally a feeling of forced sex in marriage prevailed. Majority of participants had no participation in decision making process because they assumed and accepted that their husband had final authority to take decision because they wereeconomically dependent upon them and they had to follow the husbands’ decisions otherwise they had to face the music in their marital life. That’s why decisions regarding total number of siblings, to move independently even for the sake of their reproductive health were settled by their husbands. In other words, the qualitative results supported the survey findings that the prevailing socio-economic and cultural situation had the principle influence on such reflexive attitude of married women. On the basis of major findings it is suggested that there is a need to encourage women’s employment; to promote inter-spousal communication particularly initiative taken by women and to support women’s participation in decision making process generally at household level and particularly in family formation to enable them to practice this reproductive health rights.