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Phytochemical Investigation on the Chemical Constituents of Nepeta Suavis and its Biological Activities

Thesis Info

Access Option

External Link

Author

Ullah Khan, Dr. Farman

Program

PhD

Institute

Kohat University of Science and Technology

City

Kohat

Province

KPK

Country

Pakistan

Thesis Completing Year

2011

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/14072/1/7157H.PDF

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676726924508

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غالب کے خطوط

تعارف پس منظر:
غالب کے آباؤ اجداد ترکی سے تعلق رکھتے تھے اور ان کا شمار ایبک قوم سے تھا۔غالب کے دادا قوقان بیگ ہندوستان ہجرت کر کے آئے۔یہ دور مغلیہ سلطنت کے زوال کا دور تھا۔
پیدائش:
۷۲ دسمبر ۷۹۷ ۱ء کو آگرہ میں پیدا ہوئے ان کا پورا نام بمع خطا بات مرزا اسد اللہ خان غالب (تخلص /خطاب) نجم الدولہ دبیر الملک نظام جنگ بہادرعرف مرزا نوشہ تھا۔والد کے انتقال کے بعد چچا نصراللہ بیگ نے پرورش کی آٹھ سال کی عمر میں چچا بھی وفات پا گئے۔ ان کی وفات کے بعد ننھیال رہنے لگے۔
ازدواجی زندگی:
۳۱ برس کی عمر میں نواب احمد بخش خان کے چھوٹے بھائی نواب الہی بخش خان معروف کی ۱۱سالہ لڑکی امراؤ بیگم سے شادی ہوئی۔ اللہ نے سات بچوں سے نوازا لیکن وہ سبھی بچپن میں وفات پا گئے اور بیگم کا بھی انتقال ہو گیا۔غالب ۱۵ فروری ۱۹۶۹ ء میں ۷۲ برس کی عمر میں ظہر کے وقت انتقال کر گئے۔
ابتدائی حالات:
غالب جس دور سے تعلق رکھتے ہیں وہ مسلمانوں کے زوال کا دور ہے اس وقت حکومت کا مرکز دلی تھا۔اس دور میں بادشاہوں کی حیثیت بہت معمولی ہو گئی تھی مغل بادشاہ شطرنج کا مہر بن گئے اور آہستہ آہستہ سکھو ں،جاٹوں اور روہیلوں نے زور پکڑنا شروع کیا اور اس حکومت کو گرانے میں اہم کردار ادا کیا۔ ۱۷۳۹ء میں نادر شاہ نے دلی پر حملہ کیا۔۱۷۴۸ء سے لے کر ۱۷۶۱ء تک احمد شاہ ابدالی نے بہت سے حملے کیے اور مغلوں کی رہی سہی طاقت بھی ختم کر دی۔ احمد شاہ ابدالی نے ان حملوں میں مرہٹوں کی کمر توڑ کر رکھ دی۔اس سیاسی تاریخی پس منظر میں غالب نے ہوش سنبھالا غالب کا تعلق رئیس لوگوں کے ساتھ تھا ان کی پہنچ بادشاہوں کے دربار تک تھی۔
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Biochemical Profiling and Cardioprotective Potential of Various Combination of Medicinal Plants

Myocardial infarction (MI) is the most dreaded menace and its incidences are increasing gradually. Although many of the major and minor risk factors play a crucial role in the development of MI, however the hypertension and hyperlipidemia are its major risk factors. In spite of significant pharmacological advancements regarding drug development has been made, but most of the available drugs have a long list of side effects which limit their use in clinical medicine. Hence there is a dire need to integrate complementary and alternative medications into the practice of conventional medicines, for the treatment of MI. The research was planned to be carried out into two sections including in vitro and in vivo analysis. In vitro analysis involved the screening of medicinal plants by Angiotensin Converting Enzyme inhibition assay. Among all the selected medicinal plants, methanolic extracts of Terminalia arjuna, Piper nigrum, Coriandrum sativum, Allium sativum, Rauvolfia serpentina, Eletaria cardamom and Crataegus oxyacantha showed maximum ACE inhibition potential. These medicinal plants were further subjected to LC-MS analysis which confirmed the presence of important phytoconstituents and phenolic acids in extracts. The antioxidant execution of selected medicinal plants has performed by DPPH and DNA protection assay. The dose dependant response for antioxidative potential i.e, the activity of all the medicinal plants in term of % age inhibition increased with increase in concentration. The toxicity assay of selected medicinal plants exhibited no hemolytic effect and considered to be safe herbal product for effective fighting against various diseases. Section- II comprised of In vivo analysis was conducted in three phases. The phase-I included the preliminary trial, in which the RSM optimized the dose of salbutamol (80 mg/kg b. wt.) to induce myocardial infarction. In phase-II, the optimal concentrations of selected medicinal plants were evaluated against salbutamol induced myocardial infarction by using Response Surface Methodology. In case of Phase-III, the optimized doses of selected medicinal plants were used to formulate four different herbal combinations with appropriate ratio. The herbal combination (HC4) showed maximum restoration of cardiac markers (CK-MB, AST and LDH) and haemodynamic parameters (MAP, HR, LVEDP). The histopathological examination also confirmed the cardioprotective potential of HC4. Thus the HC4 being safe, inexpensive and cardioprotective herbal combination, could be considered an alternate of synthetic drug.