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Home > Prevalence of Hepatitis C and its Associated Risk Factors in Pregnant Women of Khyber Pakhtunkhwa, Pakistan

Prevalence of Hepatitis C and its Associated Risk Factors in Pregnant Women of Khyber Pakhtunkhwa, Pakistan

Thesis Info

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Author

Zobia Afsheen

Program

PhD

Institute

University of Peshawar

City

Peshawar

Province

KPK

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Microbiology

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10825/1/Zobia%20Afsheen%20Full%20thesis.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727008334

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In the present study, we analyzed the prevalence of Hepatitis C virus (HCV) infection and its associated risk factors among pregnant women in five selected districts of Khyber Pakhtunkhwa (KP), Pakistan. The prevention of this highly infectious disease that largely remains asymptomatic, and leads to serious damage during pregnancy carries a substantial socio-economic benefit for the health and welfare of this region. The sensitivity and accuracy of the real-time polymerase chain reaction (qPCR) were also evaluated in comparison with the routine diagnostic methods: Immuno chromatographic technique (ICT), and enzyme-linked immunosorbent assay (ELISA). A total of 750 blood samples from five districts of Khyber Pakhtunkhwa namely, Mardan,Kohat, Peshawar, Nowshera, and Charsadda were screened for HCV infection using a combination of three diagnostic procedures: ELISA, ICT, and qPCR. The results showed that out of the 750 blood samples analyzed, the qPCR assay could confirm the presence of HCV RNA only in 10–30% of anti-HCV-positive samples in each district, with an average of 24% in all districts. ELISA was found to be the most sensitive method for detecting anti-HCV antibodies in 70–100% of HCV-positive blood samples in each district, with an average of 92% in all districts. ICT, which detected antibodies in 27–71% of HCV-positive blood samples from different districts with an average of 44%, is clearly less sensitive than ELISA. The overall prevalence rate in the KP, with 48 of the 750 blood samples tested positive for HCV among pregnant women, was estimated to be 6.4%, which falls within the HCV prevalence range of 4.5 to 8%, reported for Pakistan. However, there was a considerable variation in the rate of HCV prevalence at the district level, which are in order of Mardan (9.33%) >Kohat (7.33%) >Peshawar (6.00%) >Nowshera=Charsadda (4.33%). Logistic regression analysis was performed to determine the association of variables of HCV prevalence, like age, education, residential status, travel to abroad, gravidity, dilation and curettage (D&C), blood transfusion, abortion, general and dental surgery, etc., in participants found to be HCV-positive. The logistic regression model was found to be statistically insignificant (χ2 (8) = 8.785, p >0.05). The model explained 49.9% (Nagelkerke R2) of the variance in HCV-positive cases and correctly classified 95.6% of them. People with a marriage duration of 11–20 years were 17.228 times likely to exhibit HCV symptoms than people in other groups of marriage duration. Illiterates were 50.850 times more likely to acquire HCV infection than people with education. Respondents with urban residential status were 5.221 times more likely to be HCV-positive. Gravidity (primigravida) was also found to have a significant impact on HCV prevalence. A history of dental surgery is likely to increase the chances of HCV-positive status by 2.657 times, whereas the use of therapeutic injections is likely to increase the chances of HCV-positive status by 4.474 times. All other variables were found to be non-significant. District wise chi-square analysis showed age, marriage duration, education, residential status,HCV-positive husband, gravidity, dilation and curettage (D&C), blood transfusion, history of abortion, general and dental surgery, ear and nose piercing, awareness about HCV, history of accident, and use of therapeutic injections to be associated with HCV infection to variable extent in different districts. Our findings of a prevalence rate of 6.4% in KP have important health implications for a large number of pregnant women and their families as most of the infected women are ignorant of HCV infection. Since most of them are asymptomatic, they tend to have normal life implying that there exists a considerable potential for the transmission of HCV to the fetus.
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ام المومنین سیدہ ماریہ قبطیہؓ

ام المومنین سیدہ ماریہ قبطیہؓ
سیدہ ماریہ قبطیہ بنت شمعون کو بطور ہدیہ شاہ مقوقس نے آپؐ کی خدمت میں بھیجا تھا۔(تبیان القرآن جلد ۱۲ ص ۱۰۳) پر ہے’’ دو بہنیں ماریہ اور سیرین ‘ ایک ہزار مثقال سونا، بیس ملائم کپڑے، خچر(دلدل) ایک درازگوش گدھایفغور یا عفیر تھا اور اس کے ساتھ ایک خصی شخص جس کا نام ثابور تھا اور ایک بوڑھا شخص جو ماریہ کا بھائی تھا ۔اس نے مدینہ پہنچ کر اسلام قبول کر لیا تھا۔مقوقس مصر کے ہر قل (قیصر روم) کا نائب تھا۔ مقوقس اس کا لقب تھا۔مسلمان مورخین نے اس کا نام جریج بن سینا القبطی بتایا ہے۔ مقوقس نے تحائف بھیجے جن میں دو قبطی النسل کی معزز خواتین، ایک خلعت، سواری کے لیے گھوڑا( افرازہ نامی) ایک سفید خچر( دلدل) اور ایک گدھا یفغور یا عفیر شامل تھے۔(دائرۃ معارف الاسلام ج۲۱ص ۴۵۵) لیکن صاحب مدارج النبوہ ( مدارج النبوہ جلد دوم ص ۲۸۳) لکھتے ہیںکہ ان تحائف میں ایک نیزہ ،بیس قد کا لباس اور ہزار مثقال سونا، مزید لکھتے ہیں کہ حاطب بن بلتعہ کو سو مثقال سونا اور پانچ کپڑے بطور انعام کے دئیے‘‘۔ آپﷺ نے حضرت ماریہ کو حرم نبوی میں داخل فرمایا۔ان سے جناب ابراھیم پیدا ہوئے۔ساتویں روز ان کا عقیقہ کیا گیا۔سر منڈھا کر بالوں کے برابر چاندی تول کر صدقہ کی۔ دو مینڈھے ذبح کیے۔جناب ابراھیم ۱۷ یا ۱۸ ماہ کی عمر میں ہجرت کے دسویں سال انتقال کر گئے۔آپﷺ نے فرمایا: بخدا !! ابراھیم ہم تمھاری موت سے نہایت غمگین ہیں،آنکھ رو رہی ہے اور دل غم زدہ ہے مگر ہم ایسی کوئی بات زبان سے نہ کہیں گے جس سے ہمارا رب راضی نہ ہو‘‘ ۔
رسمِ باطل کا خاتمہ: جس روز آپ کا انتقال ہو ا، اتفاق سے سورج کو گہن لگا۔عرب سمجھتے تھے کہ سورج گرہن...

اسلام میں عورت کے حق طلاق کی حیثیت ایک تحقیقی جائزہ

Of the several factors that justify the greatness of Islamic Culture and survived the test of time, one is the pride of place ascribed to woman in human society. Since the dawn of Islamic civilization, woman has been respected and cored and her rights have been protected and, thus, womanfolk has been made a purposeful existence. However, Islam, being a religion of nature, does not bring woman on the line of equality with man as the Islam is the religion of justice; not that of equality. The Holy Quran has very apparently determined the rights and duties of man and woman and these all are based on natural facts and laws as well. In the contemporary times, progressive as well as west-inspired circles of our society have put numerous objections on the issue of divorce. They opine that by giving man right to divorce, woman has been deprived of equal status; hence this one-sided right has not only disturbed the family life, but put woman at an interior place. This point of view does not testify to the very facts of Islamic practices in connection with the institution of divorce. In order to understand the historical background of the institution of divorce, laws and practices in vogue in two major religions of the world-Judaism and Christianity, are discussed in a brief manner. Besides, various reforms, from time and again, introduced in divorce in west are also touched upon in nutshell. However, major portion of this article focuses on Islamic teachings regarding divorce and its implications. Therefore, this research article attempts to highlight the various aspects of divorce in the light of Islamicteachings in a comprehensive manner so as to remove the doubts of so-called west-oriented circles of our society.

Innovation Management in University Libraries of Pakistan: An Analysis of Academic Library Leaders Perceptions

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