فرنگی محلی، عبدالباری، مولانا
فرنگی محل کی آخری شمع بجھ گئی!
آہ! مولانا عبدالباری!
وَمَا کَان قَیْس’‘ ھَلْکُہٗ ھَلْکُ وَاحِدٍ
قیس کا مرنا صرف ایک آدمی کا مرنا نہیں ہے
وَلٰکِنَّہُ بُنْیَانُ قَوْمٍ تَھَدَّمَا
بلکہ پوری قوم کی بنیاد کا گر جانا ہے۔
دریغا! کہ آج قلم کو اس مجسمۂ علم و اخلاص کا ماتم کرنا ہے جس کے وصف و مدح کا فرض اس کو بارہا ادا کرنا پڑا ہے، دارالعلم و العمل فرنگی محل کی کہنہ عمارتوں میں فضل و کمال، ایمان و معرفت اور زہد و ورع کی جو آخری شمع جل رہی تھی وہ ۱۹، ۲۰ کی درمیانی شب میں ہمیشہ کے لئے بجھ گئی۔
فرنگی محل کے متاخرین میں حضرت استاذ استاذی مولانا عبدالحئی کے بعد مولانا عبدالباری کی ذات نمایاں ہوئی تھی، جو بزرگ اجداد کی بہت سی روایایت کی حامل تھی، ارشاد و ہدایت، وعظ و نصیحت، درس و تدریس، درس و تدریس، تلاش و مطالعہ، تحریر و تالیف ان کے روزانہ مشاغل تھے، ان دینی و علمی مناقب کے ساتھ دین و ملت کی راہ میں ان کا جان فروشانہ جذبہ اور مجاہدانہ اغلاص ہمرنگ شہدا تھا۔
ذاتی اخلاق، جو دوسخا، تواضع و انکسار، علم کی عزت، صداقت، حق گوئی ان کے اوصاف گراں مایہ تھے، وہ بے کسوں کے ملجا، مسافروں کے ماویٰ اور تنگدستوں کے دستگیر تھے، عبادت گزار، شب زندہ دار اور حق کے طلبگار تھے۔ ہندوستان میں ان کی ذات ذی اقتدار علماء کی حیثیت سے اس وقت فرد تھی، جدید تعلیم یافتوں کی سیاسی جدوجہد کو مذہبی تحریک بنادینا یقینا انہیں کا کارنامہ شمار کیا جائے گا۔ اس لئے ان کی یہ غیر متوقع موت صرف فرنگی محل کا نہیں بلکہ اسلام کا سانحہ ہے اور بنابریں ان کی جواں مرگی ہمیشہ کے لئے تاریخ اسلام کا ایک اندوہناک واقعہ شمار...
BackgroundFertility Preservation is the process of saving or protecting a person’s ability to have children in the future. It is often considered for individuals to undergo medical treatments that may impact their fertility, such as chemotherapy. Hence, the current study is aimed to assess clinical practitioners’ knowledge, practice, and attitude toward fertility preservation among oncologists. MethodsA cross-sectional survey was carried out to identify the current knowledge, attitudes, and practices regarding fertility preservation among oncologists—a total of seventy-nine oncologists in Karachi working in different public and private sectors. The study was conducted between January to August 2022. The data was gathered using a self-designed questionnaire that was distributed via email. ResultsOne hundred and eighty oncologists were provided with the survey form via email. The response rate was 47.22% (n=85). Out of which, six questionnaires were excluded due to incomplete information. The total questionnaire analyzed was n=79, which included 58 (73.41%) males and 21 (16.59%) females. ConclusionThe results revealed that oncologists had a compromised knowledge regarding fertility preservation for cancer patients. Despite weak knowledge, most oncologists believe that more elaborative measures should be taken to overcome this issue. DOI: https: //doi. Org/10.59564/amrj/01.01/004
The high degree of consanguineous marriages, languages, and religion are important factors responsible for high frequency of diverse hereditary disorders in Pakistani population. High incidence of inherited disorders is an ideal substrate to initiate molecular studies in Pakistani population. In this thesis I have systematically identified, phenotyped and sampled complex disorder (Schizophrenia) and rare Mendelian disorder (Primary Microcephaly) in families of different ethnicities/regions in Pakistan. Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. The symptoms appear in late adolescence or early adulthood, and mainly manifest as hallucination, delusions, cognitive deficit, abnormal moods and behavior. In this thesis 16 multiplex schizophrenia families were systematically identified, diagnosed and sampled from different ethnicities/regions of Pakistan, along with a second cohort of 508 unrelated Pakistani schizophrenia patients. Fifteen out of the sixteen families were excluded for the presence of pathogenic Copy Number Variations (CNVs) by genome wide array screening. While in one of the 16 families pathogenic rare novel duplication was detected on chromosome 5q14.1_q14.2 that truly segregated with the phenotype. Exome sequencing of schizophrenia families revealed three rare and eight common variants in two families. A set of top schizophrenia candidate genes (MIR137, CACNA1C, CSMD1, GRM3 and DRD2) was selected to evaluate their association with schizophrenia in Pakistani population. A case control association study revealed a significant difference in the genotype and allele frequencies of three SNPs between the patients and controls (p = 0.000). Autosomal Recessive Primary Microcephaly (MCPH) is a neurodevelopment defect, characterized by congenital reduction in Occipitofrontal Circumferance (OFC)/Head Circumference (HC) is at least 4 standard deviations (SD) below the ethnically matched, age and sex related mean. MCPH is associated with some degree of mental retardation which persists throughout their life without additional xx morphological or clinical symptoms. The prevalence of primary MCPH is 1 in 10,000 in Pakistani population. In this thesis six consanguineous MCPH families originating from different cities of Punjab were analyzed. Linkage analysis and exome sequencing revealed four novel and two known mutations in MCPH families. The findings in this study will help in understanding the disease mechanism and related pathways as well as annotating various entities of genome. This knowledge will help in efficient carrier screening, genetic counseling and prenatal diagnosis of affected families and ultimately to development of effective therapeutic approaches.