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Role of Nanoparticles As Contrast Agent in Imaging and Treatment Techniques

Thesis Info

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Author

Aziz, Farooq

Program

PhD

Institute

The Islamia University of Bahawalpur

City

Bahawalpur

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Physics

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13590/1/Farooq_Aziz_Physics_2018_HSR_IUB_Bahawalpur_18.07.2018.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727120586

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Nanotechnology is a fast developing research field that seems to have a large considerable interest in different areas of industry and medicine due to matchless properties of materials that lie under the nano-scale range. One such area of nanotechnology that could be positively impacted in medical field is imaging, especially X-ray Computed Tomography (CT) as well as its role in cancer treatment. Computed tomography is a 3-Dimensional imaging technique at a high spatial resolution, however it needs distribution of an X-ray contrast media (CM) to distinguish clearly the tissues with minor change density or low X-ray attenuation. Presently CT vascular contrast agents depend upon iodine which is speedily cleared by the renal system in many patients. The aim of this project was to synthesize and characterize the gold nanoparticles (GNPs) and it bases on CT contrast agents in imaging and with advantage of its role in treatment techniques. In the first instance, solid gold nanoparticles (SGNPs) and porous gold nanoparticles (PGNPs) were fabricated with naturally occurring lecithin as surfactant. Comparison of both types of gold nanoparticles was done by different characterization techniques like UV-Vis spectroscopy, Zetasizer, zeta-potential, electron microscope and check the application of both types of gold nanoparticles (GNPs) as contrast in CT scan. The results of CT imaging show that PGNPs are better contrast agents so good enhancement as compared to SGNPs. Secondly, a number of papers reported earlier with gold nanostars (GNSs) but all of these studies use same synthesis techniques with Cety trimethyl ammonium bromide (CTAB) as surfactant and PEG as coating material and this method is double or seed-mediated growth method which is very complex. In this thesis, novel strategy for growth of lecithin-coated GNSs has been introduced via lecithin as surfactant and this fabrication method consists of one pot. These GNSs show absorption peak in NIR region that shows bright future of these nanoparticles in imaging and cancer treatment. Gold nanostars (GNSs) have enlarged attention as an X-ray contrast agent because of their high X-ray attenuation, nontoxicity and one pot simple synthesis and surface functionalization for colloidal stability and targeted delivery. Experiments included the investigation of gold nanostars in CT scan in vitro by Eppendorf tubes and in vivo study in living rabbits. These GNSs with different concentration were tested as a contrast agent in CT scan, the results of in vitro CT scan study show that GNSs have good contrast enhancement properties at tube voltage of 135 kV with current 350 mA up to 640, 720, 800 HU for concentration 40, 45, 50 mg/ml, whereas the value of CT number were up to 68, 88, 108 HU for iodine with same amount and with same CT scan parameters i.e. tube voltage of 135 kV with tube current 350 mA. The result of CT scan shows that GNSs are excellent contrast enhancement agents on CT scan at 135 kV compared to iodine. In vivo study on rabbits CT scan showed that GNSs enhance the CT image clarity at 135 kV as compared to iodine. These GNSs were loaded with Doxorubicin. The result shows DOX-loaded GNSs have potential against cancer treatment. Drug release study investigated that drug release more than 50% were observed in 25 hours in PBS containing solution at pH 7.4. Drug release study investigated larger amount of drug release at 37°C compared with 25°C. The effect chemo-photothermal therapy investigated cellular loss reaches to 55%. This loss of cell viability of MCF-7 cells was investigated upto 6 hours incubation in DOX-GNSs. Then to check cytotoxicity, basic biochemical blood parameters were measured in male rabbits. In in vivo study, the influence of the intravenous (IV) route administration of these GNSs in rabbits blood shows minor increase of white blood cells (WBCs) and hemoglobin (HGB) whereas decrease of red blood cells (RBCs) and platelets (PLTs) was observed. Blood serum results show that GNSs affect more on the liver as compared to kidneys.
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ایٹمی پروگرام کا خالق

ایٹمی پروگرام کا اصل خالق کون

چئیر مین بھٹو شہید کی پھانسی کی اصل وجہ کیا تھی اور ضیاء الحق کو ایٹمی پروگرام کا کریڈٹ ؟

 

کبھی یہ سوچنا تم نے کیا کیا لوگو

یہ تم نے کس کو سرِ دار کھو دیا لوگو

یہ نظم اٹک سے تعلق رکھنے والے سابق سینیٹر شاعر دانشور احمد وحید اختر مرحوم کی ہے ۔

تو ہراساں نہ ہوا ظلم کے ایوانوں سے

تو نے جنگ لڑی وقت کے فرعونوں سے

سے قائد عوام اے قائدِ عوام

 

Antecedents of “Quality of Work” in Islamic Perspective Through Mediating Effect of Perceived Job Performance

In most of service organizations particularly in Pakistan financial sector, employees have reduced their job performance and shortened quality of work due to many factors influencing them at workplace. This research study aims to explore such antecedents in view of Islam that can improve the quality of work in banking sector wherein mediating effect of perceived job performance has been tested. Model variables of this study have also been described in the Islamic perspective. Islam is complete religion in all respect and provides foundation for quality of work. Accuracy & beatification in work, discipline, sequence of tasks, impartiality, and Islamic job satisfaction, knowing ourselves and its link with knowing to our God are parts of quality of work and employees’ performance in the Islamic point of view.  The target population of this study covers 20,514 employees of banking sector working in capital cities of Pakistan. Data were collected via cross sectional approach from 380 desk and frontline officials of Public and private banks. Confirmatory factor analysis and structural equation modeling techniques were used for data analysis. Findings of this research are demonstrated that job satisfaction and emotional intelligence are found the valuable antecedents of job performance and quality of work where employee’s job performance has been proved as a partial mediator between antecedents and quality of work. The two antecedents i.e. Job satisfaction, emotional intelligence of perceived job performance and quality of work have been supposed in this study to take as interpreters for the improvement of employees’ contentment and abilities in the working environment of banking sector. These are positively persuaded to job performance and quality of work. A practical exposure is offered by this research that organizational education about importance to employee’s satisfaction and emotional intelligence would be vital for achieving optimum results in this industry.

Analysis of Blake & Mouton's Managerial Grid and Its Application to the Management Styles of the Heads of Federal Government Educational Institutions

This study is divided into two parts. Part I undertakes an analysis of Blake & Mouton's Grid managerial styles which they formulated in the context of search for managerial excellence in the United States after World War II. The study highlights this context and documents influence of other social psychologists and scholars of related social science disciplines on Blake & Mouton who themselves belonged to the discipline of Social Psychology. Benefiting from emerging ideas about managerial styles, such as democratic style, authoritarian style, etc, the two authors came up with a clever device of depicting styles on a 9 x 9 grid with 81 cells. A manager's concern for production and people could be measured on horizontal and vertical axes on a scale of 9 points, the 9 presenting maximum concern. A manager's maximum concern for production and minimum concern for people could be termed as 9,1 style. Similarly, maximum concern for both production and people could be described as 9,9 managerial style. Blake & Mouton posited certain elements of style, e.g decision making, conflict resolving, humour/emotion, strength of conviction which in their view, could be measured on some scale. The authors used a scale of zero to five. Managers could carry out self-assessment of their styles. They could also learn to refine on the knowledge of their own styles through candid critique from peers. Blake & Mouton have emphasized that accumulated social science knowledge furnishes reliable basis to carryout self-assessment of managerial style and to choose the best style. Through analysis of various styles on social science principles, and documentation of their own observations during their consultancy work, they were convinced that on the basis of 9,9 style, development training could be undertaken to promote organizational excellence. In part-II of the study, Blake & Mouton's method of self-assessment of managerial styles has been applied in the case of educational managers working under the Directorate of Federal Government Educational Institutions (FGEIs) in Pakistan, giving background information on such institutions and the organizational setup in which the educational managers work. Questionnaires were sent to 52 heads of institutions and 104 subordinates of these heads. The response rate was 87%. Each questionnaire contained 36 items, 18 to measure concern for production and 18 to measure concern for people. The data was prepared by working out responses to questionnaire items on a six-point scale ranging from `never' to 'always' carrying value from zero (minimum) to 5 (maximum). Analysis of data, when figures were rounded for purpose of locating heads of institutions on the grid, showed the style to be predominantly a 7,8 style. This is not an authentic Blake & Mouton's Grid style. Such discrepancy has been analysed in terms of self deception, the idea that without full knowledge of Grid style through a Grid Seminar, manager's answers to questionnaire for determining grid styles are misplaced. It is then concluded that real value of Blake & Mouton's Grid styles analysis lies in the whole process of organization development which will involve not only self-assessment of managerial style but also a whole range of six phases beginning with self-assessment and ending with consolidation of organization development measures.