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Sirnas: Potential Therapeutic Agents Against Hepatitis C

Thesis Info

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Author

Muhammad Ansar

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Natural Sciences

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1744

Added

2021-02-17 19:49:13

Modified

2023-01-08 07:42:25

ARI ID

1676727175744

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ہم سے درویش کوئی مال نہ زر رکھتے ہیں

ہم سے درویش کوئی مال نہ زر رکھتے ہیں
کوئی دیوار نہ در اور نہ گھر رکھتے ہیں

یہ بھی سچ ہے کہ نہ ہم بال، نہ پر رکھتے ہیں
جاری ہم پھر بھی وفائوں کا سفر رکھتے ہیں

رکھتے بے تاب ہیں دل، آنکھ کو تر رکھتے ہیں
مرے حالات مجھے زیر و زبر رکھتے ہیں

چاکِ دامان لیے خاک بسر رہتے ہیں
تیرے دیوانے کہاں اپنی خبر رکھتے ہیں

اُن کے تُو میرے خدا! خیر سے سینے بھر دے
میرے احباب کہ جو سینوں میں شر رکھتے ہیں

روٹھنے والے بھلا بیٹھے ہیں تائب ؔہم کو
روٹھنے والوں کو ہم یاد مگر رکھتے ہیں

Significance of Philadelphia Chromosome in Chronic Myeloid Leukemia Patients of Anmol Hospital, Lahore, Pakistan

Background: Chronic myelogenous Leukemia is a form of cancer that was firstly recognizes to associate strongly with the chromosomal abnormality [t (9; 22) translocation] called Philadelphia chromosome. Objective: Philadelphia chromosome is a characteristic chromosomal marker that is associated with chronic myelogenous leukemia. Methods: More than one hundred patients of either sex were selected for the experiment. RNA was isolated from whole blood of patients so can use exclusively in RT-PCR. Results: Philadelphia chromosome in blood samples of patients with suspected diagnosis of CML was detected in 63% of patients. During our experimental studies on CML patients we do not encounter any complex translocation involving chromosome 8, 9 and 22.  Conclusions: Philadelphia chromosome is a precise cytogenetic marker the detection of which is significant for differential diagnosis and clinical organization of patients with clinical diagnosis of CML. It is of significant that Ph chromosome occurs in pre-leukemic stage and has great diagnostic significance.

Influence of Zinc and Boron Nutrition on the Perfomance of Conventional and Conservation Rice-Wheat Cropping Systems

Micronutrients deficiency particularly zinc (Zn) and boron (B), and some sustainability issues, in the conventional rice-wheat cropping systems (RWCS), are threatening the performance and productivity of this important system. Experiments were conducted at farmer field in Punjab, Pakistan to improve the productivity of conventional and conservation RWCS through Zn and B application. Residual effect of both Zn and B on the following rice and wheat both crops were also investigated. In the experiments first and second, wheat was grown under zero tillage (ZT) and conventional tillage (CT). In first experiment, Zn was applied as was delivered as foliar application (FA; 0.025 M), soil application (SA; 10 kg ha-1) and seed priming (SP; 0.5 M); while in experiment second, B was applied as SP and FA (0.01 M) and SA (1 kg ha-1). After the wheat harvest, rice was seeded in puddled-transplanted (PuTR) and direct seeded aerobic (DSAR) conditions. In the experiments third and fourth, rice was planted under PuTR and DSAR; and Zn was applied in third experiment as SA (10 kg ha-1), SP (0.01 M) and FA (10 kg ha-1). Whereas, in experiment fourth, B was delivered as SP (0.01 M), FA (0.25 M) and SA (1 kg ha-1). After the rice harvest, wheat was seeded in CT and ZT. Experiments were executed in randomized complete block design in split-plot arrangements and replicated four times. Conventional and conservation tillage in both rice and wheat significantly affected the soil health, weeds dynamics and grain yield. Soil physio-biological properties were better in zero till wheat (ZTW) than plough till wheat (PTW) evident from high soil organic matter (OM), soil organic matter (SOC) and microbial biomass nitrogen (MBN). Moreover, PTW-PuTR system had poor soil health and fertility than ZTW-DSAR. In first experiment, the ZTW yield was higher than PTW; Zn, SP in ZT improve grain yield 40% and 32.3% during first and second year, respectively. Grain Zn concentration increases by 38-58% with SA and FA, Zn. Residual effect of Zn on following rice crop improve grain yield by 19% in rice followed PTW-SA and ZTW-SA; and grain Zn concentration increased by 29% in rice followed ZTW-SA. In second experiment, B, SP in ZTW and SA in PTW increase 30.52% and 30.29% during first year; whereas 25-28% during second year, respectively. SA, FA, B increased grain B from 20-35% during both years; residual B increase rice grain yield by 36% in the ZTW-SA and PuTR-SA and grain B concentration by 30% in rice followed ZTW. In experiment 3, DSAR produced 21% and 24% higher yield than PuTR with SP and SA, Zn and grain Zn concentration increased by 57% with SA, Zn. Residual Zn effect on Zn increase grain yield by 40% in wheat followed by DSAR-SA; ZTW yield was 4.85% higher than PTW. In fourth experiment, DSAR produced higher yield than PuTR; moreover, SP and SA, Zn improved 34% and 28% respectively. Residual effect of B improved grain yield in ZTW followed by DSAR-SA by 15% and grain B concentration by 25% in wheat followed the DSAR-SA. The PuTR-PTW had poor soil structure due to highest soil bulk density, lowest soil porosity, the low OM, the SOC and MBN than DSAR-ZTW. In conclusion, switching from conventional to conservation tillage systems improved the profitability, productivity and soil health under the RWCS. Application of Zn and B and their carry over effect on following crops greatly contributed to enhance performance of rice and wheat under conservation tillage systems.