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Structural and Functional Studies on Proteins and Peptides of Cuminum Cyminum and Other Species

Thesis Info

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Author

Nazeer, Meshal

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/11936/1/Meshal%20nazeer%20chemistry%202019%20uok%20karachi%20prr.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727244331

Similar


Ajwain (Trachyspermum ammi) belongs to the family Umbelliferae, is commonly used in traditional, and folk medicine due to its carminative, stimulant, antiseptic, diuretic, antihypertensive, and hepatoprotective activities. Non-specific lipid transfer proteins (nsLTPs) reported from various plants are known to be involved in transferring lipids between membranes and in plants defense response. Here, we describe the complete primary structure of a monomeric non-specific lipid transfer protein 1 (nsLTP1), with molecular weight of 9.66 kDa, from ajwain seeds. The nsLTP1 has been purified by combination of chromatographic techniques, and further characterized by mass spectrometry, and Edman degradation. The ajwain nsLTP1 comprises of 91 amino acids, with eight conserved cysteine residues. The amino acid sequence based predicted 3D structure is composed of four α-helices stabilized by four disulfide bonds, and a C-terminal tail. The predicted model was verified by using different computational tools; i.e. ERRAT, verify 3D web server, and PROCHECK. The docking of ajwain nsLTP1 with ligands; myristic acid (MYR), and oleic acid (OLE) was performed, and MD (Molecular Dynamics) simulation was used to validate the docking results. The findings suggested that amino acids; Leu11, Leu12, Ala55, Ala 56, Val15, Tyr59, and Leu62 are pivotal for the binding of lipid molecules with ajwain nsLTP1.
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فرقت

فرقت

دل رو رو وقت گزار گیا
غم یار دا سانوں مار گیا

جدوں ماہی دے کول وسدے سی
دکھ ویکھ اسانوں نسدے سی
لوکی روندے تے اسیں ہسدے سی
کوئی دشمن دا چل وار گیا

دل یار نوں ڈھونڈن چلیا اے
کر وعدہ یار نہ ولیا اے
میرے دل وچ بھانبھڑ بلیا اے
تیر شوق دا ہو ہن پار گیا

دل یار بناء ہون رہندا نئیں
اے درد ہجر دے سہندا نئیں
دکھ درد کسے نوں اے کہندا نئیں
سکھ چین تے نال قرار گیا

عشق دے روگوں رب بچائے
یار بنا ہن چین نہ آئے
شوق سجن دا ودھدا جائے
کیوں سوہنا یار وسار گیا

قادری سائیںؔ عشق بازار نہ جاویں
جاویں تاں سچا عشق کماویں
ہک دن درشن یار دا پاویں
سوہنا ملے تاں دکھ ہزار گیا

Trash Rush – Educational Mobile Game For Android Devices

As population grows faster, the rise of garbage collection follows.  Massive information dissemination of waste management has been done by local representatives to educate people but despite the effort exerted still mismanagement of waste exist that caused serious environmental consequences to nature and human beings.  This condition ignites the researchers to develop a technology-based means to help disseminate proper disposal of garbage through the use of mobile phones.  Trash Rush educational mobile game application utilized Lua Scripting Language for game features, system behavior and synchronizes the phone sensor to the system. The Lua tool is decoded to JSON codes and sent to PHP MySQL in the webserver for storage. For tilting motion and orientation of the phone, the researchers employ the accelerometer sensor as the main navigation controller.   For sound and background effects, the Reactable Application is utilized.  The Box2D game engine is used to analyze and interpret the images and graphic effects while the Box2D API is utilized for object movement and animation. The Motion Parallax effect is also used to give more realistic effects in movements of the objects and the graphical background of the game. All these components are extracted through the APK file of Corona SDK to build and publish the app.  Upon reaching to the deployment stage of iterative model, it was found out that the system became viral to grade levels in the campus because of its story and time attack mechanism.

Liquidity Management by Islamic Banks in Pakistan: Analysis of Shariah Legitimacy and an Empirical Investigation

This research was designed to explore the liquidity management mechanisms and practices of Islamic banks in order to gain an insight of difficulties being faced by the Islamic banks in managing liquidity with the ultimate objective of finding Shari’ah compliant way-outs of such difficulties. This research has developed following econometric models (i) Liability Model—that identifies liquidity behaviours of Islamic banking depositors; (ii) Asset Model—that identifies liquidity behaviours of both the Islamic bankers and entrepreneurs; (iii) Liquidity Reserves Model—that explores factors determining the Islamic banks’ optimal liquidity reserves; and (iv) Liquidity DemandSupply Models—that investigate the resilience of the Islamic banking industry by considering different scenarios of unanticipated liquidity withdrawals. This research has found that: (a) Sukūk are the widely used liquidity management instruments by IFIs; (b) IFIs invest their excess liquidity by means of Mudārabah and Wakālah based mechanisms; (c) Commodity Murābahah is another widely used liquidity management instrument; (d) In Malaysia, there are various liquidity management instruments available, which are based on contracts of Bay’ al-‘īnah and Bay’ al-Dayn; (e) conventional liquidity management instruments are debt-based securities, therefore, are not Shari’ah compliant due to the involvement of Islamically prohibited Ribā and Bay’ al-Dayn. This research has found the liquidity behaviours of Islamic banking depositors and Islamic bankers as follows: (a) Islamic banking depositors are classified into the following three segments: (i) depositors with religious motives; (ii) depositors with profit motives; and (iii) depositors with transactional motives; (b) Islamic banking depositors withdraw their funds: (i) to fulfil their transactional needs; (ii) to relocate their term deposits’ tenor for a higher return; (iii) to shift their term deposits into other Islamic banks offering higher returns; and (iv) to place their deposits in their conventional bank’s accounts for a higher return; (c) Islamic banks, on liability side, apply following two approaches: (i) liquidity reserves are maintained for meeting the regular liquidity demands; and (ii) extra liquidity reserves are retained for meeting any unanticipated liquidity demands and for the purpose of safe sailing in times of liquidity run; (d) Islamic banks, on asset side, manage liquidity by: (i) preferring financing proposals of previously well-performed projects; (ii) requiring Rahn (collateral) or Kafālah (guarantee); (iii) preferring short-term financing; (iv) preferring to finance existing account holders; and (v) regularly monitoring the performance of their business partners; (e) Islamic banks would respond to the liquidity withdrawals exceeding the liquidity reserves by: (i) interbank borrowings or borrowing from the parent bank; (ii) selling Sukūk; (iii) withdrawing fund placements in other banks; and (iv) using bank’s equity. If further liquidity is required, Islamic banks would use emergency liquidity facility from State Bank and ask depositors to wait for extra days.