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Studies on the Chemical Constituents of Fraxinnus Xanthoxyloides Synthesis, Characterization and Biological Evaluation of Substituted Triazoles

Thesis Info

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Author

Iftikhar, Muhammad

Program

PhD

Institute

The Islamia University of Bahawalpur

City

Bahawalpur

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12639/1/Muhammad%20Iftikhar_Chem_2018_IUB_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727327304

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The history of natural products is as ancient as human being and these are used to cure man since life started. Drugs either isolated or derivative of natural products has played a great role in pharmaceutical industries and specially obtained from plants. Plants have provided us some of the very important life saving drugs used in the armamentarium of modern medicine. The exploration of the chemical constituent of the plants and pharmaceutical screening may provide us the basis for developing the lead for development of novel agents. Among the estimated 400,000 plant species, only 6% have been studied for biological activity and about 15% have been investigated phytochemically. This inadvertently shows a need for the in-depth dissertation of various chemical constituents, medicinal viability, biological and pharmacological evaluation of plants. The Part A of the present Ph. D thesis deals with isolation of bioactive constituents from a medicinally important plant of Pakistan namely Fraxinus xanthoxyloides. The search for the new chemical agents is one of the most challenging tasks for the medicinal chemist. Similarly, the synthesis of high nitrogen containing heterocyclic systems has been attracting and increasing interest among the scientists over the past decade because of their utility in daily life. In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance. The presence of three nitrogen hetero-atoms in five membered ring systems defines an interesting class of compounds, the triazole. Therefore, the present thesis is presented in the following two parts. Part A Studies on the Chemical Constituents of Fraxinus xanthoxyloides Part B Synthesis, Characterization and Biological Evaluation of Substituted Triazoles
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رئیس احمد جعفری

رئیس احمد جعفری
سید نجیب اشرف صاحب مرحوم کی موت کا زخم ابھی تازہ تھا کہ ندوے کے ایک اور نامور فرزند رئیس احمد جعفری نے بھی داغ مفارقت دیا، اکتوبر کی آخری تاریخوں میں پاکستان میں ان کا انتقال ہوا، جوار لکھنؤ کا قصبہ خیرآباد ان کا وطن تھا، مشہور شاعر، ریاض خیر آبادی کے نواسے تھے، راقم جب ندوہ میں آخری درجوں میں تھا، مرحوم ابتدائی درجوں میں تھے، عربی کی تعلیم کے بعد جامعہ ملیہ میں انگریزی کی تعلیم حاصل کی، پھر خلافت اخبار بمبئی کے اڈیٹوریل اسٹاف میں ملازم ہوگئے، بعد میں اس کے اڈیٹر بھی ہوگئے تھے، قیام پاکستان کے بعد لاہور چلے گئے۔
مرحوم میں تالیف و تصنیف کا ذوق فطری تھا، طالب علمی کے زمانے میں بھی خامہ فرسائی کیا کرتے تھے، ان کے قلم میں بڑا زور تھا، جس پر ان کی پہلی تصنیف سیرت محمد علی شاہد ہے، اس وقت ان کی عمر پچیس چھبیس سال سے زیادہ نہ رہی ہوگی، بڑے زودنویس تھے، ان کا قلم ہمیشہ رواں دواں رہتا تھا، بڑی بڑی ضخیم کتابیں چند دن میں لکھ ڈالتے تھے، ادب و افسانے سے لے کر تاریخ و مذہبیات تک میں ان کے قلم کی جولانی یکساں تھی، ہر صنف میں ان کی تصانیف موجود ہیں، اس دور کے مصنفین میں کثرت تصانیف کے لحاظ سے ان کا نام سرفہرست ہوگا، ادارہ ثقافت اسلامیہ لاہور کے قیام کے بعد اس سے متعلق ہوگئے تھے، اور اس کے لیے کئی کتابیں لکھیں، اس کے رسالہ ثقافت اسلامیہ حال المعارف میں ان کے مضامین نکلتے رہتے تھے، اس کے تازہ اکتوبر نمبر میں بھی ان کا ایک مضمون ’’عالم اسلام سے مسلمانان برعظیم کی وابستگی‘‘ شائع ہوا ہے، کیا خبر تھی کہ یہ ان کا آخری مضمون ہے۔ (شاہ معین الدین ندوی، نومبر ۱۹۶۸ء)

Determinants of Lack of Family Planning in Grand Multiparous Women Lack of Family Planning in Grand Multiparous Women

Multiparity is a matter of great concern regarding the health of women as well as child. At the same time it has different determinants and socioeconomic backgrounds. Objective: To determine the determinants of lack of family planning in grand multiparous women. Methods: It is a descriptive cross sectional study including 271 GMP patients from DHQ Hospital Okara city. Mean age was 35 ± 10 years. Data was collected with the help of questionnaire and evaluated and analyzed using SPSS version 24. Mean and standard deviation was calculated for quantitative data and frequency and percentages for qualitative data. To measure the determinants of lack of family planning, chi square test was used. P values less than and equal to 0.05 were taken as significant. Results: Most of women belong to rural area 172(63.47%) and areMuslims 259(95.5%). Most of the families lie under upper lower 149 (54.8%) and lower middle group of income 71(26.1%). The reason of last pregnancy was desire for baby boy 66(24.4%), then husband’s wish 45(16.6%)and so on. There is a good association of socioeconomic status and residence of head of family as p < 0.05, (Results are 325.272a, df = 10, p=0.000). There is an association of Gravida and socioeconomic status of head of family as p<0.05. (27.294, df= 20, p=.05). There is a good association between reasons of last pregnancy and gravida as p<0.05, (41.920, df = 24, p=0.001). Conclusions: The grand multiparty is still very common in Okara Pakistan district, considering the easy availability of modern contraceptive methods but very few women are aware of it. The most popular explanation given for present pregnancy by grand multiparous women was an urge for baby boy followed by husband wish. Most of women are Muslims. Rural Women are more socio-economically down and they have grandermultiparty.

Developing Students Speaking Skills in a Multilingual Classroom

In Pakistan English, as a Foreign and as a Second Language, is being taught from primary classes. In such classes teaching is based on rote-memorization with little meaningful activities. Teachers provide very few opportunities to students to relate their learning with their experiences in daily life. Students are mostly asked to listen passively to the teacher or read from the textbook and copy down the answers from the blackboard or from the textbook and memorize them in order to re produce them in the examinations. The study was undertaken to explore how ESL teachers could be helped to develop their students' speaking skills in ESL multilingual classroom. Using an action research approach within the qualitative paradigm, the students were engaged in different activities, which allowed the teacher and the researcher to examine the effectiveness of the strategies employed in developing students' speaking skills in English. Data collection in this study occurred in three stages. At the reconnaissance stage, observations and semi-structured interview were conducted in order to explore the teacher's understanding, and her existing practices in developing students' speaking skills in English. At the initial implementation stage, the researcher tried and tested out some strategies recommended as effective in developing students' speaking skills in English in order to examine their effectiveness in developing students' speaking skills in the multilingual school contexts, where this research was conducted. At the second implementation stage, the participant teacher was provided with the opportunity to try out the strategies in her classroom, and see the effectiveness of the strategies in developing students speaking skills in English.