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Studies on the Chemical Constituents of Fraxinnus Xanthoxyloides Synthesis, Characterization and Biological Evaluation of Substituted Triazoles

Thesis Info

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External Link

Author

Iftikhar, Muhammad

Program

PhD

Institute

The Islamia University of Bahawalpur

City

Bahawalpur

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12639/1/Muhammad%20Iftikhar_Chem_2018_IUB_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727327304

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The history of natural products is as ancient as human being and these are used to cure man since life started. Drugs either isolated or derivative of natural products has played a great role in pharmaceutical industries and specially obtained from plants. Plants have provided us some of the very important life saving drugs used in the armamentarium of modern medicine. The exploration of the chemical constituent of the plants and pharmaceutical screening may provide us the basis for developing the lead for development of novel agents. Among the estimated 400,000 plant species, only 6% have been studied for biological activity and about 15% have been investigated phytochemically. This inadvertently shows a need for the in-depth dissertation of various chemical constituents, medicinal viability, biological and pharmacological evaluation of plants. The Part A of the present Ph. D thesis deals with isolation of bioactive constituents from a medicinally important plant of Pakistan namely Fraxinus xanthoxyloides. The search for the new chemical agents is one of the most challenging tasks for the medicinal chemist. Similarly, the synthesis of high nitrogen containing heterocyclic systems has been attracting and increasing interest among the scientists over the past decade because of their utility in daily life. In recent years, the chemistry of triazoles and their fused heterocyclic derivatives has received considerable attention owing to their synthetic and effective biological importance. The presence of three nitrogen hetero-atoms in five membered ring systems defines an interesting class of compounds, the triazole. Therefore, the present thesis is presented in the following two parts. Part A Studies on the Chemical Constituents of Fraxinus xanthoxyloides Part B Synthesis, Characterization and Biological Evaluation of Substituted Triazoles
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١۔فرحت شکور

غزل ۔۔۔فرحت شکور

 

کوئی شکوہ نہیں ہے ہم کو اپنی بے نوائی سے
ملے ہیں حوصلے کیا کیا تمہاری بے وفائی سے
تمہاری بے نیازی نے جنوں کو پختگی بخشی
ہزاروں لطف پائے ہم نے تیری کج ادائی سے
یہ تنہائی یہ رسوائی تو ہے انجام چاہت کا
بھلا ہم مر نہ جائیں گے ذرا سی جگ ہنسائی سے
وہ جس نے جرمِ اُلفت کی سزا میں فرقتیں بخشی
اُسے کہنا کوئی مرتا نہیں دردِ جدائی سے
ہزاروں خواب ٹھکرا کر یہ کس کے راستے دیکھے
کوئی پوچھے مری آنکھوں کی بجھتی روشنائی سے
تمہاری یاد کے قید و قفس میں زندگی گزری
رہے محروم ہم تیرے خیالوں کی رہائی سے
یہ ممکن تھا وہ میرے شعر سن کر واہ واہ کرتا
اگر اس شوخ کو فرصت جو ملتی خود ستائی سے
وہ اپنی سلطنت کا ہی خدا ہوگا ، اسے کہنا
نہ دیکھے ہم فقیروں کو ادائے کبریائی سے
ہزاروں راہزنوں سے بچ کے جو پہنچے تھے منزل پر
انہیں یاروں نے لوٹا ہے فریبِ پارسائی سے
یہی شیوہ ہے اپنا تو بھلائی کر ، برائی سے
عوض پھولوں کے ہم نے تو ہمیشہ زخم کھائے ہیں
میرے رہوار سے جو زندگی بھر طے نہ ہو پایا
ہے کیسا فاصلہ اس ہاتھ کا میری کلائی سے
خزاؤں نے بسیرا یوں کیا ہے گلشنِ جاں میں
رہے محروم جیون بھر گلوں کی آشنائی سے
کبھی دھرتی پھٹی نہ ہی کبھی وہ آسماں لرزا
امیرِ شہر کیوں جاگے غریبوں کی دھائی سے
تیرے حصے کی خوشیوں سے بھری ہیں جھولیاں کتنی
کئی سر ڈھک گئے فرحتؔ تمہاری بے ردائی سے

Domestic Violence Against Female Beggars in Hyderabad District: A Case Study Qasimabad

This Paper analyses the causes of the domestic violence against female beggars and their impacts on their lives. The paper is strictly limited to Taluka Qasimabad, District Hyderabad. The domestic violence against women exits in various forms. However, it is pretty horrible in the form being inflicted against female beggars in Qasimabad. The scores of causes for the domestic violence against female beggars range from rising poverty to population explosions with deep physical and mental impacts on the sufferers. For data collection qualitative research through Focused Group discussion method has been used through snow ball technique. 10 Cases of female beggars have been opted for the FGDs out of which two participated with their social backgrounds. The study concludes the pathetic condition of the female beggars due to multiple factors and their serious implications both physically as well as mentally. The study recommends prompt action from the Government as well as social scientist to go deep further in the social issues such as violence against the female beggars. Simultaneously there is immediate intervention of Government and the concerned department to address these issues on emergent basis as the number is likely to reach an alarming level.

The Role of Organizational Justice and Culture in the Relationships Between Leadership Styles and Employees Performance.

The present study aimed to examine the impact of leadership styles (transformational & transactional) of the head of departments on employees (teachers) performance working in the academic department of higher educational institutions in Khyber Pakhtunkhwa, Pakistan. In similar vein, current study also examined mediating role of organizational justice and culture in relationship between leadership styles and teachers’ performance. For this purpose, data was collected from the both teachers and head of departments in the selected HEIs. The same data was then analyzed by using different statistical tools like correlation, regression, mediation and test of significance. In this regard, correlation analysis shows that all research variables are significantly correlated (table 4.14), wherein, correlation between transformational style and employees performance is (R=.915 & P-value=.000), transactional style (R=.816 & P-value=.000), organizational justice (R=.815 & P-value =.000) and organizational culture (R=.849 & P-value =.000). Similarly, cause-n-effect relationship shows that there is significant impact of predictors on criterion variable (table 4.15), wherein, the results showed that the transformational leadership is stronger predictor of employees’ performance (p- .000) as compared to transactional leadership (.020). Likewise, the mediation results (four models, table 4.40) shows that mediating variables (organizational justice & culture) partially mediate the relationship between the predictors and the criterion (tables 4.16 to 4.30a). In same line, test of significance shows diverse results about mean differences among demographic groups of respondents (tables 4.32 to 4.39). The results show that out of fourteen (14) hypotheses, eleven (11) were accepted and three (3) were rejected. However, findings of current study were positioned in Chapter 5, where these findings (current study) were compared with existing research (previous research) findings. In light of this positioning, conclusion were drawn based on certain recommendations and implications.