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Study of Organometallics

Thesis Info

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Author

Zaman, Rehmat

Program

PhD

Institute

Hazara University

City

Mansehra

Province

KPK

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Biochemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/12742/1/Rehmat%20Zaman_Biochem_Hazara_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727383123

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A series of novel and biologically potent organometallic complexes using Nheterocyclic carbenes (NHCs), cephalosporin derivatives, quinolilone derivatives, vitamins and antiviral molecules as ligands has been synthesized. The geometry of the synthesized ligands and their metal adducts are done through state of the art spectral tools like NMR (1H, 11B, 19F) UV/Visible and FT-IR. It is confirmed through these spectral studies that in the NHCs the metal is bonded through the active carbine side while in other classes metal is bonded through either oxygen or through nitrogen in some cases. After synthesizing the ligand and the metals molecules are subjected to a variety of biological tests like, antibacterial, antifungal, antioxidant, Positron emission topography and ADMET studies in order to evaluate the bio-potential of the synthesized molecules. Some of the selected compounds are screened with various microorganisms like Gram positive bacteria, Gram negative bacteria and with some fungi. The results obtained are quite impressive, it can be shown that ligands in its free state possess less activity while it is clear from the results that their activity shifts to greater extent while treated with various metals. This clearly shows that metals are responsible for the bioactivity. Further, the molecular docking study was also carried out for Tin(IV) Schiff bases complex in order to correlate the biological experimental results. As in the parent study the Tin(IV) Schiff base complexes derived from piperenol and Entecavir exhibit excellent biological results which were further confirmed through molecular docking study. For some of the molecules ADMET study was also carried out in order to check/correlate the experimental data. ADMET study also confirmed the experimental results. It can be concluded from the present study that the organometallic complexes/metal molecules can serve as potent agents in curing many diseases and may prove their role as future metal base drugs.
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وفائے دلبراں دیکھی نہ بوئے عاشقاں پائی

وفائے دلبراں دیکھی نہ بوئے عاشقاں پائی
تمھارے بعد کب ہم نے ادائے دوستاں پائی

مری ہستی تمھارے بن خزاں آلود موسم ہے
تمھارے ساتھ سے میں نے بہارِ شش جہاں پائی

حسابِ درد کو تم ٹال رکھو بادہ نوشی تک
کہ ہجرِ یار کی مے سے ہے یہ آہ و فغاں پائی

بلائے آسمانی کو نہ سمجھا کچھ مگر یہ دل
ترے ترکِ تعلق سے ہے وحشت بے نشاں پائی

تری ہستی فضائے زیست کا سامان ہے ہمدم
تجھی سے دل نکمے نے ہے خوئے دلبراں پائی

A Case Report of Non-Atherosclerotic Driven Myocardial Infarction in a Patient Presenting with Coronary Artery Spasm Non-atherosclerotic driven myocardial infarction

Background: Non-atherosclerotic processes are regarded as equally important contributors to a substantial number of coronary problems mainly myocardial infarction. This includes coronary spasm which has been considered as one of the coronary syndromes leading to myocardial infarction. These non-atherosclerotic events ensuing in major averse cardiac events (MACE) not only require various diagnostic and therapeutic strategies but also there is a need to delineate the underlying etiology for their effective treatment and management. Case Summary: We report a case of anterior wall myocardial infarction (AWMI) driven by a non-atherosclerotic event i.e. Coronary spasm. Concomitant marked ST-segment elevation recorded on ECG revealed a diffuse mid distal disease in our patient. We report here the initial presentation, coronary care & intervention and throughout the clinical course of our patient. Conclusion: Myocardial infarctionsinvolving non-atherosclerotic causes in young individuals as in our study should be reported by medical practitioners and given equal importance as they might indicate the underlying root cause of such events. Effective treatment of such future cases can be done by taking management strategies, diagnostic findings and prognostic data into consideration.

Screening and Nutrient Management of Different Indiginous Range Grasses in Thal Range Area of the Punjab.

A study on “secreening and nutrient management of different indigenous range grasses in Thal range area of Punjab” was carried out during 2007-08 at University of Agriculture, Faisalabad and Muzzafargar (Thal area) respectively. Germination vigor of buffle grass (Cenchrus ciliaris L.), dhaman grass (Cenchrus setigerous Vahl), blue stem grass (Dicanthrium annulatum Forsk), gorkha grass (Elionurus hirsutus), blue panic grass (Panicum Retz), lumb grass (Aristida depressa), fountain grass (Pennisetum orientale Rich) and Johnson grass (Sorghum halepense L. Perse) was tested against hydro and osmopriming treatments in the laboratory, University of Agriculture, Faisalabad. Ammonium nitrate (NH 4 NO 3 ), urea and farm yard manure (FYM) were applied in the field to the primed seed of grasses secreened on basis of the response of grasses to different seed priming agents. Agronomic and nutritional performance of each grass was assessed at different growth stages. Blue panic grass (77.67%), dhaman grass (75.60%), Johnson grass (69.77%) and buffle grass (63.33%), gave maximum germination percentage and got 1 st , 2 nd , 3 rd and 4 th position on over all basis of germination vigor. Whereas CaSO 4 was found best as an osmopriming agent. Primed seed of the grasses getting first four positions was directly sown in the filed. Fertilizers and Farm yard manure were applied as source of inorganic and organic of nutrients to these grasses. All others agronomic characters were found in maximum amount in Johnson grass due to FYM as compared to ammonium nitrate and urea respectively except number of tiller per plant Maximum number of tillers per plant of dhaman grass were counted under the effect of urea. From nutritional point of view, FYM also exhibited maximum protein (18.03) in buffle grass, DM (9.87%) and mineral contents (13.33%) in Johnson grass respectively. On the basis of the results use of CaSO 4 is recommended for enhancing germination vigor of indigenous grasses especially buffle, dhaman, blue panic and Johnson grass and FYM should be applied as organic source of nutrients to increase the performance of grasses under the conditions of Thal range area.