مفتی عبدالقادر
افسوس ہے کہ گذشتہ مہینہ ۲۴؍ اگست کو فرنگی محل کے نامور عالم مفتی عبدالقادر صاحب نے وفات پائی، مرحوم علم و عمل میں اپنے اسلاف کرام کا نمونہ اور طبعاً نہایت خاموش اور عزلت پسند تھے، پوری زندگی خاموشی اور قناعت کے ساتھ درس و تدریس اور علم و افتاد کی خدمت میں گذاری، ان کی موت سے فرنگی محل کی ایک اہم یادگار مٹ گئی، نئی نسل جدید تعلیم یافتہ ہے، اس کو اپنے اسلاف کے علوم اور روایات سے بہت کم علاقہ رہ گیا ہے اس لئے جو ایک دو پرانے بزرگ باقی رہ گئے ہیں ان کے بعد فرنگی محل میں سناٹا نظر آتا ہے۔
اس خاندان میں جتنی طویل مدت تک علم رہا اور اس سے پورے ہندوستان کو جو فیض پہنچا اس کی مثال دوسرے علمی خاندانوں میں کم ملے گی، عموماً دو چار پشتوں سے زیادہ کسی خاندان میں علم نہیں چلتا، مگر فرنگی محل تقریباً تین صدیوں تک دینی علوم اور اس کی تعلیم کا مرکز رہا اور اس مدت میں ملا نظام الدین بانی درس نظامیہ ، ملا حیدر ، ملا حسن، مولانا بحرالعلوم، مولانا عبدالحئی اور مولانا عبدالباری رحہم اﷲ جیسے بڑے بڑے علماء پیدا ہوئے مگر اب بظاہر اس سلسلۃ الذہب کا خاتمہ نظر آتا ہے۔
مفتی صاحب مرحوم علم و عمل کے ساتھ اخلاق فاضلہ اور اوصاف حمیدہ سے بھی آراستہ نہایت خاموش متواضع، نرم خور، خندہ جبیں، شگفتہ مزاج اور خوش خلق تھے، ملنے والوں پر ان کے علم سے زیادہ ان کے اخلاق کا اثر پڑتا تھا، ان اوصاف کی بنا پر وہ ہر طبقے میں بڑے مقبول تھے۔ راقم نے ان سے مختصر المعانی پڑھی تھی، اس زمانہ میں ان کے اخلاق اور مہرومحبت کا جو نقش دل پر قائم ہوا تھا وہ اب تک باقی ہے، اﷲ تعالیٰ اس...
This research work investigated the interfaith harmony and social cohesion between two different religious followers of Hinduism and Islam in District Swat of Pakistan. The current world is facing various kinds of issues and challenges regarding interfaith harmony, peace and social cohesion. This is need of the time to establish a peaceful and harmonised day to day life standard for all the segments of society. This research was an effort to analyse the willingness among the Hindus and Muslims for enhancing their tolerance towards each other’s social and cultural activities. It also aimed to highlight the positive approach of the respondents towards the participation in the socio-cultural activities of each other. The results of association of social cohesion showed nonsignificant relationship with an opinion that Hindu and Muslim communities should take part in socio-cultural activities particularly the sports. Similarly, non-significant relationship was found based respondents’ data with an opinion that relations between Hindus and Muslims shall enhanced through participation in cultural and religious ceremonies. The result further concluded that there was peaceful and harmonised environment between Hindus and Muslims being living in the target area. The minorities were fully enjoying freedom and equality in District Swat. Based on the findings of the study, positive social interaction, mutual respect, positivity in thinking and positive role of local media have been recommended as policy guidelines for promoting inter-faith harmony.
The focus of current research was to evaluate pharmacological ability of Acacia hydaspica methanol extract (AHM) and its derived fractions. Qualitative screening of methanol extract demonstrated the occurrence of terpenoids, anthraquinones, coumarins, cardiac glycosides, saponins, flavonoids, tannins, phlobatannins and alkaloids. GCMS chemical fingerprinting of AHM reveals the presence of 30 different chemical constituents belonging to diverse classes, owing enormous biological activities. HPLC analysis of AHM and various fractions reveals the presence of four well known standards; catechin, gallic acid, rutin and caffeic acid in AHM in varying concentrations. Catechin and Gallic acid were detected in both AHE and AHB while myrecitin was detected only in AHE. Mineral analysis indicated the existence of various macro and micromineral elements in A. hydaspica. AHB, AHE and AHM demonstrated high level of total flavonoid and phenolic content and a noteworthy correlation with the EC50 values was determined for the quenching of DPPH radical, hydroxyl radical, hydrogen peroxide radical, ABTS radical, iron chelating, β-Carotene bleaching inhibition and anti-lipid peroxidation. Significant anti-hemolytic, antimicrobial, cytotoxic actions were demonstrated by AHM and its AHE and AHB fractions. AHM and its fraction AHE reveal marked antipyretic, anti-inflammatory, analgesic and antidepressant potential. The in vivo studies indicated that AHE fraction of A. hydaspica possessed potent chemoprotective ability against cisplatin and doxorubicin induced toxicity in rats. Treatment of rats with AHE markedly improved the serum biomarkers of organ toxicity and tissue antioxidant status by significantly ameliorating the oxidative tissues markers enzymes levels near to control. Histopathological studies of different organs verify the biochemical observations. A. hydaspica was subjected to bioassaydirected fractionation which led to the isolation of three active antioxidant, antimicrobial and cytotoxic compounds from AHE and one active compound from AHB fraction besides active isolates. The compound structures were interpreted by ESI-MS and NMR spectroscopic analysis. Three AHE compounds were identified as 7-O-galloyl catechin (GC), (+) catechin (C), methyl-gallate (MG) while catechin-3- gallate (CG) was extracted from AHB fraction. In antimicrobial testing, MG was the most active compound. Isolated compounds GC, CG and MG showed more potent activity against DPPH, hydroxyl radical, nitric oxide radical, showed highest xviii antioxidant index and FRAP (649.5±1.5 μM Fe (II)/g) potency compared to standard reference rutin and gallic acid. In vitro models of prostate (PC-3) and breast (MDA-MB-231) cancer cells were used to evaluate the anticancer potential of isolated compounds (AHCs). AHC resulted in specific effects against tested prostate and breast cancer cell lines. GC, C, CG and MG inhibit cell proliferation in PC-3 cells in a dose dependent manner, whereas CG and MG negatively affected MDA-MB-231 cell growth. Compounds induce cell death via suppressing various signal transduction pathways that regulates cell proliferation and survival. Chromatin condensation, cell shrinkage and apoptotic bodies were observed by phase contrast microscopy. Compounds significantly inhibited cell survival and colony growth in both cell lines. Staining with acridine orange, ethidium bromide, propidium iodide and DAPI demonstrated that cell death occurred at least partly through induction of apoptosis in both PC-3 and MDA-MB- 231 cells. GC, C, CG and MG repressed the expression of anti-apoptotic proteins Bcl- 2, Bcl-xL and survivin in dose and time dependent manner, which futher validate the apoptotic effect of isolated compounds. Further analysis of signaling pathways indicated that compounds treatment induced a dose and time dependent suppression of JAK2, NFκB, p-Akt (Ser473and Thr308), NFκB p65 P-Ser 529, phospho-IκBa Ser32/Ser36, p-ERK1/2 (Thr202/Tyr204) in PC-3 cells. In MDA-MB-231 cells, CG and MG treatment significantly suppressed the expression of CK2α, PI3-K and JAK2. Expression of NFκB total protein and its phosphorylation at p65 P-Ser529 was significantly inhibited following treatments. Furthermore, Bcl-xL, Survivin and xIAP expression was also inhibited in MDA-MB-231 cells in a time and dose dependent manner. These findings provide strong indication that A. hydaspica compounds may be favorable therapeutic candidates against highly invasive triple negative breast cancer and androgen insensitive prostate cancer cells.