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Synthesis and Biological Evaluation of B-Hexapeptide: Anolog of Neurotensin Nt 8- 13

Thesis Info

Access Option

External Link

Author

Muhammad Arfan

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/5669/1/5422H.PDF

Added

2021-02-17 19:49:13

Modified

2023-02-17 21:08:06

ARI ID

1676727434700

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ڈاکٹر سید عبداللطیف

ڈاکٹرسیدعبداللطیف
افسوس ہے کہ گزشتہ مہینہ ڈاکٹر سید عبداللطیف بھی بیاسی برس کی عمر میں رحلت گزائے عالم جاودانی ہوگئے۔ موصوف کرنول کے ایک ممتاز خانوادہ شریعت و طریقت کے فردِ فرید تھے۔ خود بڑے فاضل نامور مصنف اورانگریزی زبان کے ادیب اوراس کے نکتہ شناس تھے۔ ایک عرصہ تک عثمانیہ یونیورسٹی حیدرآباد دکن میں انگریزی زبان کے استاد اور پھر پروفیسر وصدر شعبہ رہے۔اسی زمانہ میں انھوں نے انگریزی میں غالبؔ پرایک کتاب لکھی جس میں کلیم الدین احمد کی طرح غالبؔ کومغربی فنِ تنقید کی کسوٹی پر پرکھنے کی کوشش کی گئی تھی اور اسی بنا پر اردو زبان وادب کے حلقوں میں اس کتاب نے بیزاری کے جذبات پیدا کردیے تھے۔راقم نے بھی سب سے پہلے موصوف کانام اسی عنوان سے سنا تھا۔ اس کے بعد ان کانام اس حیثیت سے سنا کہ انھوں نے تہذیبی منطقوں کی بنیاد پر ہندوستان کی تقسیم کاایک خاکہ مرتب کیا تھا۔اس خاکہ کی وجہ سے مرحوم کو بڑی شہرت حاصل ہوئی لیکن تقسیم کے بعد ان کی زندگی میں ایک انقلاب پیدا ہوااور انھوں نے اپنی زندگی، یہاں تک کہ اپنا سرمایہ بھی اسلام کی خدمت کے لیے وقف کردیا۔اس سلسلہ میں انھوں نے مولانا ابوالکلام آزاد کی معرکۃ الآرا تفسیر سورۂ فاتحہ کاانگریزی میں ترجمہ کیا اورپھرخود بھی پندرہ بیس برس کی محنت کے بعد پورے قرآن مجید کاانگریزی ترجمہ ایک مفصل اورمفید مقدمہ کے ساتھ شائع کیا۔ زبان اوراسلوب کے اعتبارسے یہ ترجمہ قرآن مجید کے تمام انگریزی تراجم میں بڑی اہمیت رکھتا ہے ۔علاوہ ازیں ’قرآن مجید کی تعلیمات‘ اور’اسلامی کلچر‘ بھی بڑی قابل قدر کتابیں لکھی ہیں۔
وفات سے چند برس پہلے سخت ضعفِ بصارت کے علاوہ چند درچند اسقام وعوارض کامجموعہ ہوکر رہ گئے تھے لیکن کام کی دھن اور لگن ایسی تھی کہ اس عالم میں بھی اپنے خاص تلامذہ...

سد الذرائع حقيقته ونماذج من تطبيقاته المعاصرة

Today’s world is a global village. Societies affect each other far deeper and faster than ever. New problems are sprouting with every coming day. We feel that the cultural issues are the most significant ones in this context. The question is how we should deal with these problems. To us, the solution lies in the concept of Sadd al-Dharā’i‘(prevention), one of the instruments of Sharī‘ah (Islamic Law). Such is its importance as all the four schools of thought are of the same opinion about its scope. A cultural change if drives Muslims away from the objectives of Sharī‘ah, it will have to be stopped or altered to suit the objectives, but if it leads to something good without damaging the objectives of Sharī‘ah, it will be accepted. New problems are multifarious. We need to bring ijtihād into practice and solve such problems. This research article discusses the concept of Sadd al-Dharā’i‘(prevention.), its meaning, definition, and scope. It also discusses different opinions of scholars. The author of this paper, then, deliberates its use for its applications to solve the new problems being faced by the Muslims across the world.

A Randomized Controlled Trial Comparing the Proportion of Hypoxia in Sedated Adults Undergoing Upper Gastrointestinal Endoscopy Using Target Controlled Infusion of Propofol Versus Intermittent Boluses.

Background: A wide variety of sedation techniques are employed to facilitate various invasive diagnostic and therapeutic procedures. Increasingly, propofol is emerging as the preferred sedative agent. Traditionally, it has been administered as intermittent boluses to achieve deep sedation to facilitate gastrointestinal endoscopy. Propofol target controlled infusion can be employed to provide suitably conducive conditions for this purpose. Objective: The primary objective sought to compare the proportion of hypoxia between the study group receiving intermittent boluses of propofol at 0.25mg/kg as needed, and the other receiving target-controlled infusion of propofol at 2.5mcg/ml during upper gastrointestinal endoscopy. The secondary objectives were to compare the occurrence of hypotension, bradycardia, and the time to wake up between the two groups. Primary outcome measure: Decrease in oxygen saturation below 90 percent (SpO2 <90%) Secondary outcome measures: Decrease in systolic blood pressure of more than 20% from baseline; decrease in heart rate to less than 50 beats per minute. Study design: prospective, single centre, randomized controlled trial Study setting: The Aga Khan University Hospital, Nairobi. Sample size: One hundred and seventy-six participants were enrolled; 88 belonging to the intermittent bolus arm and 88, to the target-controlled infusion arm. Study population: Included all ASA I and II patients between the ages of 18 and 65 years scheduled to undergo upper gastrointestinal endoscopy (oesophagogastroduodenoscopy) under sedation. Sedation procedure: One hundred and seventy-six participants were allocated randomly into one of two groups corresponding to the mode of propofol used for sedation (a) Premedication with midazolam 0.05mg/kg added to an initial bolus of propofol 1mg/kg, followed by repeat boluses of 0.25mg/kg as needed (B, n = 88) and (b) Premedication with midazolam 0.05mg/kg added to an initial target effect-site concentration of 4mcg/ml, followed by maintenance target effect-site concentration of 2.5mcg/ml, titrated upward or downward by 0.5mcg/ml from baseline infusion rate as needed (T, n = 88). Oxygenation and haemodynamic parameters were evaluated by determining oxygen saturation, blood pressure and heart rate immediately before administering the sedative and at 2.50, 5.00, 7.50 and 10.00 minutes. Standard care was, in addition to the above, provided. Data collection: A data collection tool was used to record data (refer to appendix V). Patients’ baseline vital signs, including blood pressure, heart rate and oxygen saturation were entered. Any occurrence of oxygen desaturation below 90% in both study groups was also recorded. The sedation starting time, stopping time, waking up time and overall duration of time