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Home > Synthesis and Characterization of 2 3H -Furanones, 2 3H -Pyrrolones, Quinolinones, Thienochromenones, Thienopyridinones and Biological Activity of Some Selective Compounds

Synthesis and Characterization of 2 3H -Furanones, 2 3H -Pyrrolones, Quinolinones, Thienochromenones, Thienopyridinones and Biological Activity of Some Selective Compounds

Thesis Info

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Author

Sajid Ali

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2135

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727439702

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Reaction of 3-(4-substitutedbenzoyl)propionic acid with appropriate aromatic aldehydes in the presence of triethylamine in acetic anhydride gave 3-arylidene-5-(4- substititutedphenyl)furan-2(3H)-ones. Reaction of furanones with benzylamine gave γ-ketobenzylamides which were then cyclized to 1-benzyl-3-arylidene-5-(4- substituted phenyl)-1H-pyrrol-2-(3H)-ones by refluxing with 6N-HCl. Two series of furanones and pyrrolones were synthesized. The synthesized compounds were evaluated for antioxidant, cytotoxicity and urease inhibition activities. These compounds showed non significant antioxidant activity, nil brine shrimp lethality and low to moderate urease inhibition activity. Reaction of hitherto unknown 4-chloro-3-(2,2,2-trifluoroacetyl)-2H-chromen- 2-one with different commercially available anilines gave 3-(trifluoroacetyl)-4- (arylamino)-2H-chromen-2-ones which were then successfully cyclized to 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones with conc. H2SO4. Suzuki cross-coupling reaction of methyl-3-bromothiophene-2-carboxylate and ethyl-2-bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate methoxy phenylboronic acids gave the successfully cyclized to with o- arylated products which were then thieno[2,3-c]chromen-4-ones and 7,8,9,10- tetrahydrobenzothieno[3,2-c]chromen-6-ones via BBr3 mediated lactonization. The Sonogashira cross-coupling reaction of methyl-3-bromothiophene-2- carboxylate and 2-bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with terminal alkynes gave respective alkynyl products. The ester and nitrile groups of these substituted thiophenes were then converted into amides which were then cyclized to 5-substituted-thieno[2,3-c]pyridin-7(6H)-ones and 3-substituted-5,6,7,8- tetrahydrobenzothieno[3,2-c]pyridin-1(2H)-ones via base-promoted-cyclization. 4,5-Disubstituted thieno[3,2-b]pyridin-7(4H)-ones were synthesized by Pd- catalyzed tandem amination reaction of α,β-ynone with commercailly available anilines/amines. The method provides an efficient thienopyridinones.
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کتابیات

کتابیات
بنیادی ماخذات
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Islam is a complete religion which provides guidance not only for spiritual life but about material aspect of life also. There is a clear code of business ethics to be followed in trade. Unfortunately Islamic ethics are being ignored in our society. In this article, reasons of our current materialistic unethical point of view in trade and some suggestions to resolve the problem are being discussed

Effect of Allelopathic Plants on Morphoanatomical Features of Wheat

This study was conducted to evaluate the effect of allelopathic plant on growth and morpho-anatomical features of wheat. Three experiments were conducted in order to study the allelopathic effects of root, stem, leaf and fruit of Dodonea viscosa, Eucalyptus camaldulensis, Fumaria indica, Juglans regia, Melia azedarach, Olea ferruginea,Sapindus mukorossi, Tamarix indica and Taraxacum officinale on growth and morpho-anatomical features of Wheat variety Pirsabaq 2005 during 2013-2016 at experimental field and laboratory, Department of Botany, Hazara University Mansehra. The present investigation showed that all the applied allelopathic plants parts have adverse effect on germination, morphological and anatomical parameters of wheat. Results of germination revealed that leaf aqueous extracts > Fruits> Root > Shoot. The degree of sensitivity of wheat in respect of growth to applied applications was Melia azedarach > Sapindus mukorossi > Taraxacum officinale > Juglans regia > Fumaria indica > Eucalyptus camaldulensis > Olea ferruginea > Tamarix indica > Dodonea viscosa. Root, stem, leaf of Olea ferruginea increased the diameter of xylem, phloem, and mesophyll tissue of root, stem and leaf of wheat which directly effect the physio-morphology of wheat. Fumaria indica has stimulatory effect on radical and plumule length, it also increases morpho-agronomic characters and anatomical character of wheat. Fruit of Melia azedarach is least effect of on germination and morpho–agronomic and anatomical character of wheat. The fruit of Sapindus mukorossi is highly harmful for germination, morphology, agronomy,and anatomical features of wheat and partially block the xylem and phloem as result it retard germination, morphology,agronomy of wheat. Dodonea viscosa is less toxic as compare to Tamarix indica and Juglan regia and Eucalyptus camadulensis for wheat growth and anatomical parameters. It is concluded that stem of Eucalyptus camaldulensis is highly toxic for all the morpho-agronomic characters of wheat i-e length of internode,length of spike, grain yield. Soil analysis shows that all allelopathic plants decrease the nitrogen in soil while phosphorus is deficient in Tamarix indica leaf and Melia azedarch treatments. Similarly potassium value increase in all treatments as compare to control. Maximum electric conductivity was observed in Eucalyptus camadulesis stem. pH values do not show significant difference in all treatments. Eucalyptus camaldulensis, Melia azedarach, Sapindus mukorossi,Tamarix indica, Juglans regia decrease the germination, growth and yield of wheat. Olea ferruginea and Fumaria indica show stimulatory effect on germination and other morpho-anatomical features of wheat. This study would be helful to understand the nature of allelopathic plants either they have allopathic effect or allelopathic potentials for different crops. Some allelopathic plants would be benficial and harmful for the growth of different crops due to allelochemicals. Biofertilizers and bioherbicides can be prepared from the allopathic plants for crop improvement.