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Home > Synthesis and Characterization of 2 3H -Furanones, 2 3H -Pyrrolones, Quinolinones, Thienochromenones, Thienopyridinones and Biological Activity of Some Selective Compounds

Synthesis and Characterization of 2 3H -Furanones, 2 3H -Pyrrolones, Quinolinones, Thienochromenones, Thienopyridinones and Biological Activity of Some Selective Compounds

Thesis Info

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External Link

Author

Sajid Ali

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2135

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727439702

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Reaction of 3-(4-substitutedbenzoyl)propionic acid with appropriate aromatic aldehydes in the presence of triethylamine in acetic anhydride gave 3-arylidene-5-(4- substititutedphenyl)furan-2(3H)-ones. Reaction of furanones with benzylamine gave γ-ketobenzylamides which were then cyclized to 1-benzyl-3-arylidene-5-(4- substituted phenyl)-1H-pyrrol-2-(3H)-ones by refluxing with 6N-HCl. Two series of furanones and pyrrolones were synthesized. The synthesized compounds were evaluated for antioxidant, cytotoxicity and urease inhibition activities. These compounds showed non significant antioxidant activity, nil brine shrimp lethality and low to moderate urease inhibition activity. Reaction of hitherto unknown 4-chloro-3-(2,2,2-trifluoroacetyl)-2H-chromen- 2-one with different commercially available anilines gave 3-(trifluoroacetyl)-4- (arylamino)-2H-chromen-2-ones which were then successfully cyclized to 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones with conc. H2SO4. Suzuki cross-coupling reaction of methyl-3-bromothiophene-2-carboxylate and ethyl-2-bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate methoxy phenylboronic acids gave the successfully cyclized to with o- arylated products which were then thieno[2,3-c]chromen-4-ones and 7,8,9,10- tetrahydrobenzothieno[3,2-c]chromen-6-ones via BBr3 mediated lactonization. The Sonogashira cross-coupling reaction of methyl-3-bromothiophene-2- carboxylate and 2-bromo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with terminal alkynes gave respective alkynyl products. The ester and nitrile groups of these substituted thiophenes were then converted into amides which were then cyclized to 5-substituted-thieno[2,3-c]pyridin-7(6H)-ones and 3-substituted-5,6,7,8- tetrahydrobenzothieno[3,2-c]pyridin-1(2H)-ones via base-promoted-cyclization. 4,5-Disubstituted thieno[3,2-b]pyridin-7(4H)-ones were synthesized by Pd- catalyzed tandem amination reaction of α,β-ynone with commercailly available anilines/amines. The method provides an efficient thienopyridinones.
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ہاشم شاہ

ہاشم شاہ(۱۷۵۶ء۔۱۸۲۱ء) میں موضع جگد یوکلاں تحصیل اجنالہ میں پیدا ہوئے۔ آپ کے والد حاجی محمد شریف اپنے عہد کے پیرِ طریقت تھے۔ ہاشم نے انھی کے ہاتھ پر بیعت کی۔ آپ کے والد مختلف علوم اور زبانوں کے ماہر ہونے کے علاوہ حکیم حاذق بھی تھے۔ مہاراجہ رنجیت سنگھ جب ان کے علاج سے صحت یاب ہوا تو خوش ہو کر تھرپال نزد ریہ نارووال ان کو انعام میں دیا۔ ہاشم تا دمِ مرگ ۱۸۲۱ء یہیں رہے(۶) سرور ارمان نارووال کے شعرا کے تذکرے میں ہاشم شاہ کے بارے میں رقمطراز ہیں:

ہاشم شاہ نے فارسی‘ پنجابی اور اردو میں شاعری کی مگر ان کی شہرت کا بڑا سبب ان کی لکھی ہوئی عشقیہ داستاں سسی پنوں ہے۔ جس سے ان کا شمار پنجابی کلاسیکی شعرامیں ہوتا ہے۔ اس کے علاوہ ہاشم شاہ نے سوہنی مہینوال‘ شیریں فرہاد‘ لیلیٰ مجنوں ‘ ہیر رانجھا اور دوہے بھی پنجابی زبان میں لکھے۔(۷)

ہاشم شاہ عشقِ حقیقی کے قائل تھے۔ ان کے آباؤ اجداد میں سب پیر اور روحانی پیشوا تھے۔ آپ نے باطنی طور پر حضرت پیر عبد القادر جیلانیؒ سے روحانی فیض حاصل کیا۔ پیر عبد القادر کی منقبت سے چند اشعار ملاحظہ ہوں :

اس گناہیں کے لیے یا پیر غفاری کرو                             اب تو کچھ پردہ نشیں پر حال ستاری کرو         

دستگیری کجیو ڈرتا ہے ہاشم پر گناہ                  دستگیر بے کساں یا غوث الاعظم بادشاہ         (۸)

دنیا کی بے ثباتی بھی ہاشم کی اردو شاعری کا موضوع ہے۔ ہاشم سمجھتے تھے کہ دنیا کی زندگی عارضی ہے اور ہر کسی انسان نے دنیا سے آخرت کی طرف سفر کرنا ہے۔ اس حوالے سے اشعار ملاحظہ ہوں:

کہاں سکندر کہاں ہے دارا جام کہاں ہے جم کا                 جن کی تیغ سے دیو بھی کانپے دل دہلے رستم کا               

ان کی راکھ ملے نہ ڈھونڈے دنیا گھر ہے غم کا                 ہاشم جان...

The veil in the west countries between the religious freedons and secular codes

يأتي حجاب المرأة المسلمة في صدارة النقاشات السياسية على اعتباره مصدر تهديد حقيقي لعلمانية الغرب وعقلانيته، فأصبح الحجاب هاجسًا مقلقًا للغرب خاصة بعد أحداث 11 سبتمبر 2001 الدامية والتي أدت إلى تزايد العداء ضد الإسلام والمسلمين ولعل أبرز مظاهره حجاب المرأة المسلمة الذي تعرض لحملات تشويه كبيرة وتمثل الوجه الآخر للإرهاب بل هي صانعه. وعليه، تهدف هذه الدراسة إلى إبراز الحملة التي تتعرض لها المرأة المسلمة في أوروبا وتحديدا فرنسا وهذا من خلال قراءة وتحليل قانون حظر الرموز الدينية الذي استهدف الحجاب بالدرجة الأولى. ولتحقيق هدف الدراسة فقد استخدمت الباحثتان المنهج الوصفي التحليلي من خلال استعراض مختلف الرواسب التاريخية المتحكمة في الظاهرة محل الدراسة، وتوصلت الدراسة إلى مجموعة من النتائج أهمها: يمثل قانون حظر الحجاب في الدول الغربية ممارسة عنصرية ضد الإسلام والمسلمين، ويمثل موقف الدول الغربية من حجاب المرأة المسلمة تكريسا لخطاب الكراهية المعادية للإسلام والمسلمين والحرص على قيادة العالم والهيمنة عليه سياسيا وثقافيا وحضاريا

The Best Managerial Practices Bmps Framework for Upgrading Ranking of the Business Institutions in Sindh

Developed countries can become advanced through their quality education system. The quality is important in all aspects of life but the quality in the education sector having the top priority. Several countries constitute their quality standards advancing in line with other education standards to control the educational practices in HEIs. Unfortunately, the quality of the Pakistan’s HEIs is not that well maintained as other competed advanced countries. The one way to improve the quality of HEIs in Pakistan is set a target to upgrade their national and international ranking status. Ranking helps institutions to build their position and image worldwide and enable them to compete internationally. In Pakistan the ranking of HEIs is measured by HEC. However, the designed ranking parameter by HEC are adopted and modified from two international rankings namely: QS and THE ranking system. It is a major research gap in the literature that if HEC adoption the parameters and criteria from international ranking system than why Pakistani universities does not meet the international standards. This research aims to fill this gap through identification of the best practices that enables HEIs to become internationalize and further few more parameters in the HEC ranking proforma that possess international standards. This research is focused on two goals: the first goal is to identify those criteria and parameter that are desired in international standards. Second goal is to explore those practices that are considered as best practices in the national and international ranking system and to explore their adaptability and existence in the business institutes in Sindh. In Pakistan this study is based on mix methods however more focused on quantitative methods. For qualitative method, face to face interviews were conducted and practices were explored and clustered around themes. For quantitative method, semi structured research questionnaire was designed for data collection. The key words of this thesis are best practices, national and international ranking and higher education. The data for this research is collected from Quality Enhancement Cell (QEC) of the business institutes in Sindh. In this study, 263 questions in a semi structured questionnaire were got filled from the twelve business institutions. Pre testing (pilot study) for data collection was carried out in three business institute of Sindh namely; IoBM, Karachi IBA, and IBA Sukkur to examine the feasibility and validity of the study. Based on the results of pilot study, the questionnaire was modified to obtain better results. The tools used in this research are: comparison charts, stacked bar charts, descriptive statistics, hierarchical cluster analysis and logistic regression through SPSS. As this research is based on two goals. The results of this study have two research outputs: first proposed best practices model comprises of fifty best practices through which the HEIs can maintain and upgrade their quality standards and to compete internationally through secure positions in international rankings. Second is the proposed ranking proforma for the HEC to improve their quality standards and enables HEIs in Pakistan to compete globally.