In the present study, 62 heteroleptic Pd(II) complexes have been synthesized by reacting PdCl2 with sodium dithiocarbamate salt and different organophosphine in mixed solvent system of methanol and acetone. The different dithiocarbamate ligands used were sodium salt of dibenzylcarbamodithioate (L1), (4-chlorobenzyl)(4-methylbenzyl)carbamodithioate (L2), benzyl(cyclopenta-1,3-dien-1-ylmethyl)carbamodithioate (L3), 4-(2-hydroxyethyl)piperazine-1-carbamodithioate (L4), 4-benzhydrylpiperazine-1-carbamodithioate (L5), dimethylcarbamodithioate (L6), diethylcarbamodithioate (L7), and bis(2-hydroxyethyl)carbamodithioate (L8). The organophosphines used were triphenylphosphine, diphenyl-p-tolylphosphine, tri-p-tolylphosphine, tris-p-chlorophenylphosphine, tris-p-fluorophenylphosphine, tri-o-tolylphosphine, tri-m-tolylphosphine, tris(4-methoxy-3,5-dimethylphenyl)phosphine, tricyclohexylphosphine, chlorodiphenylphosphine, 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,4-bis(diphenylphosphino)butane. These complexes were characterized by different spectroscopic techniques like elemental analysis, FT-IR, multinuclear (1H, 13C and 31P) NMR and single crystal XRD. DFT calculations were also carried out for some representative complexes (1-10). The neutral complexes (1-42) showed a pseudo square planar geometry around palladium metal with two cis sites occupied by a bidentate dithiocarbamate moiety forming four-membered chelate ring (PdS2C) and the remaining two are occupied by a chloride and a monodentate organophosphine. However, in the cationic complexes (43-58) the latter cis positions are occupied by the phosphorous atoms of the bidentate organophosphine. The chlorodiphenylphosphine was oxidized in the aforementioned solvent system and unexpected products were obtained with two phosphine oxide attached to the metal center through phosphorous in cis position (59-62). Some of the representative ligands and complexes were screened for in vitro cytotoxic activity against human liver cancer cell line (HepG2) using MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods using doxorubicin as standard drugs. Generally, the heteroleptic Pd(II) complexes comprising bidentate organophosphine, {1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,4-bis(diphenylphosphino)butane}, fluoro and iv uncoordinated group (carbonyl and oxygen) were found to be most active as compared to the standard drug (doxorubicin). The selected Pd(II) complexes were also evaluated to check their cytotoxicity using brine shrimp assay. The highest activity was found for compounds containing oxygen and fluoro substituents.
مولانا خلیل الرحمن افسوس کہ مولانا خلیل الرحمن صاحب سابق ناظم ندوۃ العلماء نے ۴؍ فروری ۱۹۳۶ء کی شب کو اپنے وطن سہارنپور میں اس دار فانی کو الوداع کہا، مولانائے مرحوم مولانا احمد علی صاحب محدث سہارنپوری (محشی بخاری و تلمیذ مولانا شاہ محمد اسحق دہلوی) کے چشم و چراغ تھے، مولانا احمد علی مرحوم پچھلی صدی کے آخری دور میں ہندوستان کے ان باکمالوں میں تھے جن کی مسندِ درس سے علم دین کی شمع روشن تھی اور تشنگانِ علم اس سرچشمہ سے سیراب ہونے کے لئے سینکڑوں میل کی منزلیں پاپیادہ طے کرکے وہاں تک پہنچتے تھے، مولانا خلیل الرحمن نے علم کے اسی گہوارہ میں آنکھ کھولی اور اپنے والد ماجد کے دامنِ فیض میں تعلیم و تربیت پاکر فارغ التحصیل ہوئے۔ مرحوم ندوۃ العلماء کے دور اول کے محسنین میں سے تھے، مولانا محمد علی مونگیریؒ ناظم ندوۃ العلماء کی معیت میں اس ملی و علمی خدمت میں شریک ہوئے اور آخر تک رہے، مرحوم خوش خلق، متواضع، رحمدل، اور عزیزوں سے دلی محبت فرمانے والے تھے، اتفاق وقت کہ دارالعلوم ندوۃ العلماء کی ہنگامہ خیز اسٹرائک کا واقعہ انہی کے دور نظامت میں پیش آیا تھا، اس نازک وقت اور ناسازگار حالات میں بھی مولانائے مرحوم دارالعلوم کے طلبہ کے ساتھ جس عدیم المثال شفقت و محبت سے پیش آئے، اسکی یاد اس عہد کے فارغ التحصیل علمائے ندوہ کے دلوں میں ہمیشہ کے لئے باقی رہ گئی، اور مدت گزرنے کے بعد انہیں جب کبھی مرحوم سے شرف ملاقات کا موقع حاصل ہوا انھوں نے ان کے دل کو شفقت و محبت سے لبریز پایا ندوۃ العلماء کی خدمات انجام دینے کے علاوہ مرحوم کی زندگی کا ایک اہم کارنامہ صحیح بخاری کے اس نادر نسخہ کی اشاعت ہے، جس پر ان کے والد ماجد کے حواشی ثبت ہیں، یہ...
Plagiarism is a serious offense that defies the ethics of scholarship and research. Research students need to pay substantive attention to the dynamics and contours of plagiarism in their creative, ethical, and academic endeavors. Scholarship avenues such as online tutorials and work assignments are important sources of instructions for plagiarism-avoidance among students. The current study explores the frequency of consultation of scholarship avenues and the usage of plagiarism-avoidance techniques among research students in social sciences. The study also recommends a scale to investigate plagiarism-avoidance techniques. Furthermore, it also examines the level of the study in predicting the usage of plagiarism-avoidance. Using the online survey technique, 108 research students from Pakistan were sampled. The questionnaire was uploaded on several student-based research groups of social media, including; Facebook, and Yahoo groups. Bivariate linear regression analysis was used for hypothesis testing. Findings revealed that scholarship avenues lead to greater usage of plagiarism-avoidance techniques among research students (R2 =0.065). Supervisors, class-fellows, colleagues, and faculty of the department are prominent human scholarship avenues. Similarly, articles and books from the web, books from the library, the anti-plagiarism policy of the Higher Education Commission (HEC), and lectures delivered in the classroom were leading informational scholarship avenues. Stage of the study and consultation of the scholarship avenues were predictors of usage of plagiarism-avoidance techniques. It is recommended that (i) plagiarism-avoidance is promoted through prevention rather than detection, and that (ii) scholarship avenues (e.g. Delivering lectures, institutional policy, and interaction with relevant websites) are used for enhancing awareness about intellectual dishonesty.
Background: Hypotonic fluids are widely used in pediatrics and are the standard of care when giving maintenance fluids. However, there are several reports of risk of iatrogenic hyponatremia attributed to this practice in the literature. There is therefore uncertainty as to whether isotonic fluids would be the more appropriate fluid. Objectives: The primary objective was to compare effects of hypotonic and isotonic maintenance fluids on plasma sodium levels in children between the ages of 2 months and 15 years admitted at Aga Khan University Hospital (AKUH). The secondary objective was to compare effects of hypotonic and isotonic maintenance fluids on other plasma electrolytes and need for additional fluid boluses in the same population of patients. Study design: Double blind randomized controlled trial of isotonic vs hypotonic maintenance intravenous fluids in children. Methods: One hundred and fifty two children with serum sodium levels between 130-150 mEq/L who required intravenous maintenance fluids were randomized to receive either 0.9% dextrose normal saline or hypotonic maintenance fluids as per normal practice. Hypotonic solution which was used in the control group, had sodium concentration between 20 and 100 mEq/L corresponding to 4mEq/Kg/24hr. Children aged between 2 months and 15 years requiring hospitalization at AKUH were eligible only when their physician prescribed intravenous maintenance fluid therapy. Patients with chronic or acute kidney failure/disease, at risk of cerebral edema (diabetic ketoacidosis or cranio- encephalic trauma), neonates (age <2month >old), sickle cell, with plasma sodium levels at hospital admission <130mEq/L or >150mEq/L, and/or cerebral malaria or severe malnutrition ( Z score <-3) and who refused to consent were excluded. Children were clinically monitored as per standard protocol. Blood electrolytes were obtained before commencement of v infusions to determine those eligible for inclusion and repeated after 24 hours or when fluids were stopped whichever was earlier. Any undesirable side effects were documented and managed as per standard practice. Primary outcome: Proportion of children with hyponatremia at 24hours after administration of maintenance fluids. Results: A total of 152 subjects were enrolled after obtaining informed consent. Of these, 78 and 74 were randomized to isotonic and hypotonic groups respectively. Overall, 25 (16.4%) patients dropped out of the study for various reasons. Hyponatremia occurred in 16.4% of the patients at 24 hours and a higher proportion of patients (23%) in the hypotonic group experienced hyponatremia compared to the isotonic group (10.3%) that was statistically significant (p = 0.03). The relative risk of