This research work is based on synthesis of various coumarin derivatives and structure of those derivatives were confirmed by using different spectroscopic techniques like IR, λmax, 1H NMR, 13C NMR ESI-MS etc. These derivatives were then utilized to make different metal complexes with Cu and Ag metals. The synthesized complexes were then characterized by using IR, atomic absorption; thermal gravimetric analysis, powder XRD, mass spectrometry and their magnetic properties were also studied by VSM. Finally coumarin and coumarin derivatives and all metal complexes (M= Cu, Ag) were used against different pathogens to study their antibacterial activity. All coumarin derivatives and metal complexes shown antibacterial activity against any one of the bacterial strain and inhibited their growth.Metal complexes found to be more efficient against bacterial strains than coumarin ligands.