Search or add a thesis

Advanced Search (Beta)
Home > Synthesis Characterization and Biological Sciences of Some Novel Schiff Base Derivatives of Ferrocence and Their Metal Complexes

Synthesis Characterization and Biological Sciences of Some Novel Schiff Base Derivatives of Ferrocence and Their Metal Complexes

Thesis Info

Access Option

External Link

Author

Jawaria, Rifat

Program

PhD

Institute

Bahauddin Zakariya University

City

Multan

Province

KPK

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10436/1/Rifat_Jawaria_Chemistry_2016_BZU_Multan_HSR_04.10.2017.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727476828

Similar


Focus of this research work is on the synthesis and biological studies of ferrocenyl thiosemicarbazones and their transition metal complexes. Two series of Schiff’s base derivatives of acetylferrocene (58-71 & 87-101) were synthesized by the condensation of acetylferrocene with appropriate benzylthiosemicarbazides (44-57) and phenylthiosemicarbazides (72-86) in ethanol under the catalysis of acetic acid. All these compounds were fully characterized by IR, 1H NMR, 13CNMR spectroscopic and EIMS spectrometric data. Crystallographically studies of ferrocene-based thiosemicarbazones have been conducted in order to investigate the prevalence of the thioamide dimersynthon and carbon bonding. All the compounds have shown a general preference for the adoption of the cis, trans conformation about the central thiourea moiety which is ideal for the formation of a dimeric hydrogen-bonded {···H–N–C=S}2 synthon as the building block. This dimeric synthon is observed in all the compounds, with the methyl group particularly set for playing its supportive stabilization role through C-H···S and carbon bonding interactions. The structural features and ground state geometry calculations have been computed at B3LYP/6- 31G** (LANL2DZ) level of theory. The computed geometrical parameters, bond lengths, bond angles and dihedral angles are in reasonable agreement with the X-ray crystallographic data. We shed light on the frontier molecular orbitals; highest occupied molecular orbitals (HOMOs), lowest unoccupied molecular orbitals (LUMOs) and HOMO-LUMO energy gaps. The intra-molecular charge transfer (ICT) was observed in all the studied compounds. The excited state geometries have been optimized by using the time-dependent DFT. Metal complexes of benzylthiosemicarbazones (102-127) were prepared by reacting with metal salts (CuCl2, CoCl2, Zn(acetate)2 and Ni(acetate)2) with benzylthiosemicarbazones in 1 : 2 ratio respectively. All the complexes were characterized by IR, UV-Vis, Molar conductance and Magnetic moment. Crystal structure of Co(II) (120) complexe was grown and characterized to confirm the structure and geometry of metal complexes. The crystallographic data confirmed the tetrahedral geometry of synthesized metal complexes. The synthesized thiosemicarbazones and their metal complexes (58-127) were tested against acetylcholenesterase (AChE), butyrylcholinesterase (BChE), alpha glucosidase, lipoxygenase (LOX) and antioxidant activities. In general, all newly synthesized metal complexes (102- 127) showed higher inhibitory activities than their respective ligands. The Cu(II) complex (102) was found to be the most potent against acetylcholenesterase as well as butyrylcholenesterase having IC50 values 9.21±0.29 μM and 12.70±0.27μM respectively while its ligand was in active. For alpha glucosidase activity, the metal complex (106) was highly active with IC50 value 0.8±0.19μM (%inhibition= 99.92±0.21) while its respective ligand did not show considerable activity (% inhibition 15.71±0.66). Similar behavior was observed for lipoxygenase (LOX) enzyme where compound (122) was most active (IC50 = 15.02±0.0 μM, % inhibition = 93.58±1.21) while its ligand was inactive. The Co(II) complex (121) showed moderate DPPH radical scavenging activity with % inhibition of 83.74±0.96 (IC50 = 169.67±0.75μM). High biological activities of metal complexes as compared to their respective ligands highlighted the importance of complexation. The studies show the importance of new class of thiosemicarbazones and their metal complexes that enhanced their biological interest.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

بہت ہی میٹھی ہیں پیارے رسولؐ کی باتیں

بہت ہی میٹھی ہیں پیارے رسولؐ کی باتیں
سو آؤ کرتے ہیں اپنے رسولؐ کی باتیں

خدا کرے کہ یونہی عمر اپنی کٹ جائے
کبھی خدا کی تو گاہے رسولؐ کی باتیں

ہر ایک شے پہ مقدم نبیؐ کا فرمایا
ہر ایک بات سے آگے رسولؐ کی باتیں

سو سیدھی سچی ضمانت ہیں کامیابی کی
ہمارے حق میں ہمارے رسولؐ کی باتیں

زمانہ اُس کو خس و خاک میں بدلتا ہے
ہوا میں جو بھی اُڑائے رسولؐ کی باتیں

جو دین سیکھنا چاہے خلوصِ نیت سے
وُہ عائشہؓ سے تو پوچھے رسولؐ کی باتیں

زمانہ یوں ہی تو روشن خیال ہوتا ہے
کہ لو دکھاتی ہیں سچے رسولؐ کی باتیں

خدا بھی اُس کو یقیناََ بُھلائے گا عابدؔ
وُہ شخص جو کہ بھلائے رسولؐ کی باتیں

علمائے کرام، قائد اعظم اور نظریہ پاکستان

In this article the role played by the Muslim religious scholars in the Pakistan Movement has also been discussed. The most prominent among such scholars were Molana Mazharuddin Malik, Molana Shabeer Ahmad Usmani, Molana Ashraf Ali Thanvi, Molana Zafar Ahmad Ansari, Mufti Muhammad Shafee, Molana Ikram Khan Bengali, Molana Ahmad Raza Khan Brailvi, Molana Naeem Uddin Muradabadi, Molana Azad Subhani, Molana Abdul Hamid Badauni, and MolanaAbul Ala Maududi. At the end, an analysis of the ideology of Pakistan has been presented in the light of the excerpts taken from various speeches and statements made by the Quaid during 1938 and 1948. It shows that the Quaid wanted to make Pakistan an Islamic state governed by the teachings of Allah Taala. He wanted to make it a model Islamic state to convince others to realize that the commandments of Allah are practicable and are a means of salvation from hurdles and hardships.

Immunocompetence of Feral Birds Against Anseriformes Originated Newcastle Disease Virus

Birds living in densely-populated (urban) areas are exposed to different environmental challenges. One of them is an exposure to a vast range of environmental pathogens simply due to lack of appropriate biosafety and biosecurity measures in hospitals and research centers. Therefore, wild/feral birds living in close vicinity to urban settings are hypothesized to be more immunocompetent and/or resistant to different pathogens than are birds living in rural settings. This hypothesis of varying immunocompetence in birds originating from rural and urban setting was evaluated using an endemic pathogen of birds, the Newcastle disease virus (NDV).The virus was isolated from migratory bird, the mallard (Anas platyrhynchos), at Chashma barrage and was found to be virulent on the basis of genomic (typical F protein cleaving motif: 112R-R-Q-K-R↓F117) and biological characteristics (EID50 =108.5 mL-1 and MDT= 49.5-50 hrs). Immunocompetence among individual group of each of 20 feral birds (pigeon, mynah, sparrow, crow and quail), both from urban and rural settings (n=10), were administered 0.1mL of a mitogen (1mg/mL), the phytohemagglutinin (PHA) and thickness of patagium at different time intervals as 12, 24, 36, 48 and 60hr of post injection was measured through digital caliper. Post administration of PHA, all studied birds’ species showed a similar pattern of increase in web-thickness by the timer interval of 48 hours followed by a decline by 60 hr. Though variations in magnitude of swelling were observed among and/or within birds’ specie group, compared to their respective rural counterparts, birds originating from urban setting showed an enhanced swelling response (e.g., 1.26 2 mm ±0.03 vs 0.980 mm ±0.04 for pigeon, 0.235 mm ±0.02 vs 0.194 mm ±0.03 for sparrow, and 1.10 mm±0.03 vs 0.855 mm±0.04 crow) by 48 hours. For instance, in case of rural and urban pigeon, difference in thickness was continuous for each of the time interval (p < 0.05) whereas, in case of crow, this difference between birds in rural and urban setting was limited to time interval of 24 hrs (95% CI: 0.024-0.082; p < 0.05), 36 hrs (95% CI: 0.026-0.085; p < 0.05), 48 hrs (95% CI: 0.052-0.110; p < 0.05) and 60 hrs (95% CI: 0.036-0.097; p < 0.05). On the other hand, a lack of significant difference was found between urban and rural groups of sparrow, mynah and quail birds (p > 0.05). Following comparative immunocompetence evaluation, all birds were acclimatized for two weeks to diminish the effect of PHA and then challenged with Newcastle disease virus (1mL of 10-8 EID50/mL) isolated from mallard. The results of this study indicated that the urban birds were more resistant as evidenced by increased morbidity and mortality pattern, tissue tropism and virus shedding from 3rd dpi by 9th dpi among birds group. The study birds showed an equal potential to disseminate the virus in apparently healthy chicken where 100% mortality was observed in broiler by 6th dpi. The study outcome ascertains a need for continuous monitoring and surveillance of wild/migratory birds for NDV and also implementation of strict biosecurity measures not only in commercial setting but also in public sectors to control the spillover of pathogen to environment and wild birds.