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Home > Synthesis of Derivatives of Benzothiazole Via Palladium and Copper Catalyzed Reactions and Their Biological Activities

Synthesis of Derivatives of Benzothiazole Via Palladium and Copper Catalyzed Reactions and Their Biological Activities

Thesis Info

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Author

Gull, Yasmeen

Program

PhD

Institute

Government College University

City

Faisalabad

Province

Punjab

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13001/1/Yasmeen%20Gull%20Ph.D%20Thesis.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727482732

Similar


The use of catalytic cross-coupling methodologies for preparing aryl functionalized derivatives is an emerging field. Benzothiazole is a heterocyclic compound, weak base, having various biological activities and still is of great scientific interest now a days. Halogenated 2-aminobenzothiazoles were prepared with reported methodology. Suzuki cross coupling was done with Pd(0) and N-arylation at amino group using copper as a catalyst. The synthesis of different derivatives of 2-amino-6-bromobenzothiazole and 2-amino-6- chlorobenzothiazole were investigated. Suzuki cross coupling reactions were done with various aryl boronic acids/ aryl pinacol esters. Suzuki cross coupling gave product with good yields. Suzuki cross coupling reaction was carried out in which Pd(PPh3)4 was used as a catalyst and K3PO4 as a base. Suzuki cross coupling of 2-amino-6-bromobenzothiazole was also tested with aryl and heteroaryl trifluoroborates. Chan-Lam coupling was carried out at amino group in benzothiazole using Cu(OAc)2 as a catalyst without base, and reacted with different aryl boronic acids along with aryl trifluoroborates. Biological activities were also tested for these new series of compounds. Most of the compounds showed excellent antiurease properties. These newly synthesized compounds showed moderate to good nitric oxide scavenging, antibacterial and haemolytic activities.
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کلیاتِ مکاتیبِ اقبال مرتبہ سید مظفر حسین برنی کے حواشی،تعلیقات اور اشاریہ سازی

خطوط اظہارِ خیال اور تاثرات کی ترسیل کا مستند ترین ذریعہ ہیں۔ خط میں مکتوب الیہ اپنے جلوت و خلوت کے احوال و کیفیات کا اندراج بے تکلفانہ انداز سے کرتا ہے اور اپنی دلی کیفیت کا اظہار کرتا ہے۔ اقبالیاتی ادب میں افکار کا بحرِ بے کراں پوشیدہ ہے۔اگر ہم اقبال کے خطوط کا مطالعہ کریں تو ایسے گراں قدر گوہر نصیب ہوتے ہیں جنہیں پڑھ کر حیرت ہوتی ہے۔ یہ حیرت فہم و فراست کے دریچے کھول کر فکر و فن کی نئی راہوں کا مسافر بنا دیتی ہے۔ قاری اپنی بصیرت کو بروئے کار لاتا ہے اور نئی دنیا کی تلاش میں نکل کھڑا ہوتا ہے۔اس طرح فکر و فن کے جواہر علم و ادب کے خزانے کو مزیّن کرتے ہیں۔ماہر اقبال شناس اپنی صلاحیتوں کے بوتے پر اقبالیات کے لیے نئی راہوں کی تحقیق و تصدیق کے لیے کوشاں ہیں۔ ایسی ہی اقبال شناس شخصیت ہندوستان کے سید مظفر حسین برنی کی بھی ہے۔سید مظفر حسین برنی کا تعلق”برن“ (بلند شہر) کے ایک ذی وقار خانو ادے سے تھا۔آپ نے جس گھرانے میں آنکھ کھولی اس میں خدمت علم وادب کی ایک طویل اور مسلسل روایت رہی ہے۔آپ 14، اگست1923ء کو بلند شہر میں پیدا ہوئے۔آپ کا تعلیمی سلسلہ بہت عمدہ رہا۔ آپ نے بی۔اے میں انگریزی ادب میں ٹمپل گولڈ میڈل حاصل کیاپھر انگریزی ہی میں ایم۔اے بھی کیا۔1947ء میں انڈین ایڈمنسٹریٹو سروس”آئی اے ایس“ کے مقابلہ کے پہلے امتحان میں کامیاب ہوئے اور ریاست اڑیسہ میں تعینات ہوئے۔مرکزی حکومت نے آپ کی صلاحیتوں سے بھر پور استفادہ کیا۔آپ جوائنٹ سیکرٹری کمیونٹی ڈویلپمنٹ رہے۔محکمہ زراعت میں جوائنٹ سیکرٹری رہے۔ایڈیشنل سیکریٹری وزارتِ پٹرولیم وکیمیکلزکاانتظامی عہدہ سنبھالے رکھا۔وزارتِ اطلاعات و نشریات کے اہم ترین ادارے میں سیکریٹری رہے۔بورڈ آف ریونیو میں رلیف کمشنر رہے۔چیف سیکرٹری اور ڈویلپمنٹ کمشنر کے اعلیٰ ترین عہدوں پر ذمہ...

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