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Home > Synthesis of Hydrazide and Sulfonamide Derived Schiff Bases and Their Antioxidant and Bioactivities

Synthesis of Hydrazide and Sulfonamide Derived Schiff Bases and Their Antioxidant and Bioactivities

Thesis Info

Access Option

External Link

Author

Hayat, Muhammad

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10170/1/Muhammad_Hayat_Chem_2018_UoK_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727484223

Similar


This research work consists of the synthesis of Schiff bases and sulphonamides derivatives of nicotinic and isonicotinic acid hydrazide by adopting different synthetic chemical transformations and tested of their antioxidant and bioactivities. All compounds were entirely characterized by a variety of spectroscopic techniques like EI-MS and 1H-NMR. Four chapters have been included in this critique based on the broad literature and it is regarding the three series of the synthetic compounds. Everyone has its own references, compounds tables, figures, schemes and numbering. Chapter-1 It is consisting of broad literature review related to the common introduction of Schiff bases and nicotinic acid and its reaction, various synthetic protocols and biological background. It has been also studied the several biological activities which are done on compounds. This chapter describes the synthesis of Schiff bases of nicotinic acid hydrazides 131-163 and studies of their antioxidant, antileishmanial, urease, α-glucosidase, anti glycations, α-chymotrypsin, acetylcholinetorase, butyrylcholinesterase, tyrosinase, xanthine oxidase, anticancer and antimicrobial activities. Chapter-2 Describes the synthesis of Schiff base derivatives of isonicotinic acid hydrazides 40-69 and studies of their antioxidant, antileishmanial, antiglycation, urease, α-glucosidase, α-chymotrypsin, tyrosinase, xanthine oxidase, anticancer and antimicrobial activities. Chapter-3 Describes the syntheses of sulfonamide derivatives of nicotinic and isonicotinic acid hydrazides 77-99 and their urease inhibitory activity, antioxidant, antiglycation, immunomodulatory and antimicrobial activities. In chapter-4, we describe bioassay protocol used for the all compounds.
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مولانا عبدالرشید نعمانی

مولانا محمد عبدالرشید نعمانی
اگست کے آخری عشرہ میں پاکستان سے یہ اندوہ ناک خبر آئی کہ مولانا محمد عبدالرشید نعمانی جے پوری کا کراچی میں انتقال ہوگیا، اناﷲ وانا الیہ راجعون۔
مولانا کی نظر دینی علوم تفسیر، حدیث اور رجال پر اچھی اور گہری تھی۔ ان کی تعلیمی زندگی کا کچھ زمانہ دارالعلوم ندوۃ العلماء لکھنؤ میں بھی بسر ہوا۔ ملک کی تقسیم سے پہلے اور بعد میں بھی ان کا تعلق ندوۃ المصنفین دہلی سے رہا۔ یہیں سے ان کی کتاب لغات القرآن شایع ہوئی جو ایک مفید قرآنی خدمت ہے، یہ حروف معجم پر مرتب کی گئی ہے اور چھ جلدوں میں مکمل ہوئی ہے۔ شروع کی چار جلدیں جو الف سے شروع ہو کر ع پر ختم ہوئی ہیں مولانا نعمانی کے قلم سے ہیں اور آخری دونوں جلدیں مولانا سید عبدالدائم جلالی نے مرتب کی ہیں، پہلی جلد کے شروع مولانا عبدالرشید نعمانی کا بسیط مقدمہ ہے جس میں کتاب کی نوعیت اور اس کی ترتیب میں ملحوظ رکھے جانے والے امور کے علاوہ اپنی محنت و جاں فشانی وغیرہ کا ذکر کیا ہے۔ دہلی میں قیام کے زمانے میں ماہنامہ برہان میں ان کے مضامین بھی شایع ہوئے۔
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دور حاضر میں کرنسیوں کے ادھار خرید و فروخت کا شرعی جائزہ

Foreign Exchange trading is when you buy and sell foreign currencies to generate profit. In our age of advance technology even the virtual or digital currencies have now emerged. This entire business however is mostly based upon speculation and prediction. Even the most skilled and experienced traders face difficulty in predicting movements in currencies. Further, the value of not well established currencies can fluctuate or its exchange rate value can change any time. In view of occupying central place in the economic systems down the ages, Muslim scholars have also vehemently discussed currency, its significanc and matters relating to it in transactions. The present article reviews trading of foreign currencies from Islamic perspective in a situation when no cash is involved in the transaction. The article concludes that as the currencies in such transactions are different commodities, therefore their trade is legal.

Impact of Corporate Governance and Corporate Social Responsibility on Firms Performance: A Moderating Role of Corporate Philanthropy

The paper examines the effect of Corporate Governance and Corporate Social Responsibility on firm’s performance in the listed companies of Pakistan Stock Exchange in the presence of Corporate Philanthropy. The study employs yearly data spanning over the period of 2004 to 2017. Variables such as Corporate Governance, Corporate Social Responsibility and Firm Specific Variables serve as independent variables, Corporate Philanthropy as a moderating variable and firm’s performance proxies by Earning Yield, Tobin’s Q, Return on Assets and Return on Equity as dependent variables in the model. Data has been extracted from Annual reports of the firms, Security &Exchange Commission of Pakistan, Pakistan Stock Exchange and Pakistan Center of Philanthropy. Results deduced that Corporate Governance and Corporate Social Responsibility have significant effect on firm’s performance. The data has been analyzed with a view to check cause and effect relationship by using Multivariate Panel Data Analysis. Generalized Method of Movement (GMM) / Dynamic Panel Method (DPM) method is used to ensure that there are no issues of Reverse Causality, Feedback affect, Endogeneity and Simultaneity. Firm Age, Leverage, Board Independence, CEO Duality, Miscellaneous Project of Social Responsibility, Cash Donation, Earthquake and Natural Disaster have negative impact on firm’s performance i.e. Earning Yield, Tobin’s Q, Return on Assets and Return on Equity. However, Firm Size, Education Sector, Infrastructure Development, Charity in shape of material and Miscellaneous Project of Philanthropy have positive impact on firm’s performance. Mixed results were found in case of Board Size and Corporate Social Responsibility. While considering the Earning Yield and Return on Assets as a firm’s performance, Board Size has negative and Corporate Social Responsibility has positive impact on Earning Yield and Return on Assets. The role of Corporate Philanthropy as moderator between Corporate Governance and firm’s performance is also significant. Corporate Philanthropy represents negative significant moderating effect in relation with Firm Age, Firm Size and Leverage; moreover, it has positive significant moderating effect in relation to Board Independence and Board Size. Results also reveal that Cash Donation, Infrastructure Development and Natural Disaster show significant positive moderating effect on Board Independence with firm’s performance. Similarly, Infrastructure Development and Miscellaneous Project of Philanthropy have also shown positive moderating impact on Board Size and Firm Size with firm’s performance. After using the GMM / DPM technique, three out of five different settings of Corporate Governance, Corporate Social Responsibility and Firm Specific Variables on firm’s performance in the presence of Corporate Philanthropy encountered problem of Reverse Causality, Feedback’s influence, endogeneity and simultaneity. These results showed no variation from previous findings except Corporate Social Responsibility has positive significant impact on firm’s performance. Results confirmed that Corporate Philanthropy moderates the relation between Corporate Governance and firm’s performance. Results reveal that Market based measures (Earning Yield and Tobin’s Q) are more dynamic in nature. Nonexistence of standard format for reporting philanthropy data poses difficulty in making rational analysis and developing uniformity basis for all the firms. The philanthropic contribution of any organization is attributed towards the enhancement of firm’s performance. Results unfold that this study will be a guideline for regulatory bodies to formulate a comprehensive policy framework to Pakistan Stock Exchange so that uniformity of reporting philanthropy should be adhered.