Search or add a thesis

Advanced Search (Beta)
Home > Synthesis of Novel Derivatives of Heterocyclic Compounds Containing Fused Pyridine Ring

Synthesis of Novel Derivatives of Heterocyclic Compounds Containing Fused Pyridine Ring

Thesis Info

Access Option

External Link

Author

Nazeer, Areesha

Program

PhD

Institute

University of the Punjab

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/2742/1/3119S.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727490254

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


The present work deals with the synthesis of pyridine fused heterocyclic compounds, three condensed pyridine systems were selected for this project; Benzo[b]pyridine (Quinoline) (a), Pyrazolo[3,4-b]pyridine (b) and Pyrano[2,3-b]pyridine (c).Various strategies were utilized for introducing an ester functionality on the 4 position of (a) and (b) by utilizing Doebner-vonMiller reaction or additionally the use of Pfitzinger’s synthesis of quinolines. For (c) the ester group was introduced at the 3 position by applying a Knoevenagal condensation of ethyl acetoacetate and 2-hydoxypyridine-3- carbaldehyde. These ester groups in (a), (b) and (c) were converted to their respective carbohydrazides which were condensed with a number of arylcarbaldehydes to furnish their hydrazones. The final cyclization to the 1,3,4-oxadiazoles were effected by using various methods. POCl3 was very useful for this purpose. The products of the systems (a). (b) and (c) were thus synthesized and fully characterized by IR, 1HNMR, 13CNMR and MS and elemental (C,H andN) analyses.The results obtained confirmed the formation of the desired products. The final products were screened for their antioxidant and enzyme inhibition activities. viii Some azabicyclic compounds (I, II, III) were also prepared through ring closure metathesis by using Grubbs catalyst (Second Generation). These compounds were prepared through a multisetp strategy involving alkylation, RCM, decarboxylation, hydrolysis, Curtius reaction and finally cyclization to get the desired bicyclic compounds.These were characterized through 1HNMR, DEPT and HRMS.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

جماعت اسلامی کی امارت سے علیحدگی

۱۹۴۰ء سے ۱۹۷۷ء تک مولانا مودودیؒ نے ذوالفقار علی بھٹو کی تحریک " اسلامی سوشلزم" کی زبردست مخالفت کی۔مولانا نے ۲۱ سال تک جماعت اسلامی کی رہنمائی کی ۔ آپؒ یکم نومبر ۱۹۷۷ء کو بیماری اورکمزوری صحت کی بناپر جماعت اسلامی کی امارت سے مستعفیٰ ہوئے ۔

Negotiating the Pre-9/11 Muslim Identity in Reluctant Fundamentlist and Home Boy

This paper critically analyses pre-9/11 diasporic identity of Muslims living in the US as immigrants or expatriates depicted in The Reluctant Fundamentlist (TRF) and Home Boy (HB) authored by minority outgroup Muslims (MO). The pre-9/11 identity and image of Muslims has exacerbated from erotic, primitive, barbaric, ignorant, close-minded and semicitizen to maddened, fundamentalist, blood-thirsty and terrorist after the attacks. The study attempts a textual analysis of the novels in the light of Rosenau’s model (2003) of diasporic acculturation process and social identity theory (ST). Given this stereotyping, this study endeavours to dissect the pre-9/11approach Muslims immigrants adopt to negotiate their religious identity in the hostland: whether they are fanatic and diehard separatist or they are moderate and assimilative into the enlightened values of the West. Opposite to popular assumptions, the protagonists have been found very much assimilative and adoptive to the host culture and also adhere to their homeland culture as well.

Effect of Plant Growth Promoting Rhizobacteria and Rock Phosphate Enriched Compost on Growth, Yield and P Nutrition of Cereals

Relatively poor bioavailability of P in soil from the applied expensive phosphatic fertilizers due to fixation/precipitation is considered one of the most critical factors in limiting optimum crop yields. Thus use of cheap P sources and enhancing P bioavailability is considered viable approach/ strategy and is direly needed under the current prevailing situation for sustainable crop production. Rock phosphate (RP) is a cheap source of P but cannot be used directly as a soil amendment because of its extremely poor water solubility (0.1%). However, the bioavailability of RP-P can be enhanced by complexing it with compost and/ or through the use of specific bioinoculants. A series of studies were conducted to determine the effectiveness of various approaches to solubilize RP-P and the impact of bioavailable RP-P on growth and yield of wheat and maize under wire house and field conditions was assessed. Two soil incubation studies were conducted for 15 weeks to determine the potential of solubilization of RP. In first study soil was spiked with RP, RP + P-solubilizing bacteria (PSB), while in second study soil was amended either with RP, RP + compost, RP- enriched compost (RP-EC) and RP-EC + PSB to determine the release of bioavailable P from RP. Results of first incubation study revealed that RP + PSB, while in second study, RP-EC + PSB resulted in maximum release of plant available P in soil. In both the studies, addition of RP alone did not provide plant available P in soil. The results of these incubation studies were further investigated for their validity by conducting a series of pot and field trials on wheat and maize. Firstly, the efficacy of PSB and ACC-deaminase PGPR in solubilizing RP-P and uptake of P on wheat was investigated. The results verified the findings of incubation trial as bioinoculants (PSB or PSB + ACC-deaminase PGPR) plus RP significantly improved growth contributing parameters of wheat in comparison to RP alone. The results of growth parameters of wheat recorded in case of RP plus PSB + ACC deaminase PGPR were almost comparable to NPK control. Similarly RP-EC substitutions of 25% or 50% of the P requirements of the crop in the presence or absence of bioinoculants were also investigated for their impact on growth of test crops compared to NPK control. Results recorded that without inoculation, 25% replacement of P dose by RP-EC proved better than NPK control while substitution by 50% of P dose with RP-EC was relatively less effective than NPK control. However inoculation with PSB or PSB + ACC-deaminase PGPR proved effective under all the fertilizer treatments with different degree of efficacy. Application of 50% RP-EC with 24dual inoculation of PSB and ACC-deaminase PGPR proved to be the best combination in promoting growth and yield of wheat and maize in both pot and field trials. Similarly P contents as well as P-uptake of grain and straw improved substantially. Other treatments also produced higher yield contributing traits than uninoculated NPK control but with relatively less efficiency. The findings further verified the results of soil incubation studies with respect to their effectiveness of various treatments. It is very likely that both compost and PSB helped in solubilization of insoluble P while ACC-deaminase supported efficient uptake of P by improving root growth. The results of these studies may imply that RP-EC plus seed inoculation with novel PGPR proved to be a viable approach to use low grade RP and organic waste for sustained crop production as well as for promoting healthier environment.