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Home > Synthesis of Novel Oxadiazole Derivatives and Related Heterocyclic Compounds In-Vitro and In-Silico Evaluation

Synthesis of Novel Oxadiazole Derivatives and Related Heterocyclic Compounds In-Vitro and In-Silico Evaluation

Thesis Info

Access Option

External Link

Author

Muhammad Akram

Program

PhD

Institute

The Islamia University of Bahawalpur

City

Bahawalpur

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10875/1/Muhammad%20Akram_Chem_2018_IUB_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727491140

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In the present work three series of Mannich bases of 1,3,4-oxadiazole-2(3H)-thione (121170) have been successfully synthesized with good to excellent yield and comprehensively characterized by FTIR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Furthermore, their in-Silico and in-vitro evaluation showed them as excellent urease inhibitors which were even better than standard. All the synthesized compounds were also evaluated for their antioxidant properties as well as antiviral activities against the four poultry viruses (IBA, H9N2 , NDV, and IBDV). The synthetic strategy for the synthesis of these Mannich base derivatives are as under. Synthesis and Biological evaluation of pyrazinyl based derivatives (119-135) The strategy for the synthesis of targeted compounds is elaborated in Scheme 29. Ethyl pyrazine-2-carboxylate (119) was prepared by the esterification of pyrazine-2-carboxylic acid (118), which was further converted into pyrazine-2-carbohydrazide (120) by refluxing with 80% hydrazine hydrate in ethanol. The synthesized hydrazide underwent cyclization to yield 5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione (121) upon reacting with CS2 in alkaline medium. Which was then further converted to respective Mannich bases 3-[{(substituted phenyl)amino}methyl]-5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione or 5-(pyrazin-2-yl)-3[{(substitutedpyridin-4-yl)amino}methyl]-1,3,4-oxadiazole-2-thione (122-135).
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The era of caliphate was the golden era of Islam. In this era the boundaries of Islamic state spread far and wide. From the caliphate of Abubakkar saddique (RA) Islamic conquest had started. At that time the Muslim armies reached Syria and Byzentine. But the first arrival of sahaba in Afghanistan was in the caliphate of Hazrat Umar (RA). The torchbearer of Islam came here for the preaching of Islam and to lead these people and turn their lives according to Quran and Sunnah. Before the advent of  Islam Afghanistan was the centre of Buddhist and other several faiths. Through the efforts of these companions of Muhammad (S.A.W) Islam got spread through the mountains and deserts of Afghanistan and all the Pathan tribes enter in the holy deen. In the following lines we will discuss thier efforts and journeys towards Afghanistan.

Evaluation of Impact of Climate Change on Pakistans Agriculture: Spatial and Temporal Analysis

The most crucial challenge in 21st century is the threat to agriculture sector through global climate changes. It has caused a significant impact on water and energy resources, agriculture sector and consequently food supply especially for developing countries. Pakistan is the frontline state confronting the serious concerns of climate change particularly grave water shortage. Its economy has been facing the challenges of global warming, devastating floods, persistent droughts, rising sea levels etc. Keeping in view extreme vulnerability to climate change, a comprehensive economic valuation was quantified across time and region so as to bring some workable policy solutions for the agrarian economy of this country. 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At continent level, climate changes were found to be blessings for Europe and America while Asia was found as the most vulnerable continent to climate change besides Africa that is also facing vulnerability to climate change. Funnel asymmetry plot and FAT showed that literature was free of publication bias and heterogeneity. Likewise PET showed negative effect of climate change on farm land values. The study also investigated the extreme climate events including flood zone, drought trends and severity. The cotton-wheat Sindh was most drought prone zone followed by rice-other Sindh, other Balochistan and cotton-wheat Punjab. The interpolated drought index assessed Chagai, Kharan, Panjgur, Kech, Gawadar and Awaran from Balochistan and Jacobabad, Shikarpur, Sakhar, Larkana, Nowshehro Feroz, Nawab Shah, Dadu and Khairpur from Sindh most susceptible to drought. 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Climate response to net farm revenues in irrigated regions was estimated by loss of 6586 Rupees for irrigated and 117 Rupees in rainfed region indicating that irrigated region is more vulnerable to climate change in comparison to rainfed region. Threshold level of minimum temperature in rainfed is 18 C and in irrigated region is 20 C while optimal precipitation level in rainfed is 626 mm and in irrigated regions is 958 mm. farm type adaptation to climate change estimated through logistic regression proposed that for increased temperature, the irrigated farmers will prefer crop only farming and rainfed farmers will prefer mixed farming. However, the precipitation increase will attract farmers towards mixed farming in both regions. 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