This dissertation is divided into seven chapters. The first chapter is general overview which introduces transition metals catalyzed cross coupling reactions especially Palladium catalyzed cross-coupling reactions. These have recently emerged as one of the most powerful and fundamental transformations in organic syntheses. Among the several palladium catalyzed cross-coupling reactions, Suzuki-Miyura cross-coupling reaction has become an extremely important method for the construction of carbon-carbon bonds. The second chapter describes the synthesis of fluorinated terphenyls synthesized via Suzuki cross coupling reaction of 1, 4-dibromo-2, 5-difluorobenzene with different boronic acids. Fluorinated terphenyls were obtained in high yields. Structures of these compounds were confirmed by 1H-NMR, 13C-NMR, GC-MS, FT-IR and single crystal X-Ray analysis. Mono-arylation was also observed in a compound 4, 4’-dibromo-2, 5-difluorobiphenylby using 1 equivalent of arylboronic acid. The third chapter describes the syntheses of 3-arylated quinolines synthesized via Suzuki cross coupling reaction of 3-bromoquinoline with different boronic acids. Several trials were made to enhance yield of final products by using different catalytic systems. Extensively diversified arylated quinolines were synthesized in relatively high yields. Structures of these compounds were confirmed by 1H-NMR, 13C-NMR, GC-MS, FT-IR and single crystal X-Ray analysis. Synthesized arylated quinolines are not readily available by any other methodologies. The Fourth chapter describes the syntheses of 2, 5-diarylated pyridine synthesized via Suzuki cross coupling reaction of 2,5-dibromopyridine with different boronic acids. Diversified results were obtained as 4 different products 5, 6, 8 and 9 were obtained even after using 2.2 equivalents of different aryl boronic acids. Regioselectivity is also studied and well characterized with help of XRD analysis. Abstract x The fifth chapter describes the experimental procedures and characterization data of synthesized compounds. The sixth chapter describes the biological activities of the synthesized compounds. These compounds were subjected to various biological activities like anti-bacterial, anti-fungal, antinociceptive and urease inhibition activities. The overall biological activity screening demonstrated that majority of these compounds are significantly bioactive. The last chapter describes the solubilization of quinoline derivatives in micellar solutions of surfactants. In micellar solutions of surfactants the solubility of the quinoline derivatives increased linearly with the increase in surfactant concentration irrespective of the type of surfactant. The molar solubilization ratio (MSR), micelle-water partition coefficient (KM), and the Gibbs energy of solubilization (Δ???) of these compounds in the micelles were determined and correlated with each other. This comparative study can be used to select an appropriate medium for the quinoline derivatives solubilization.
اردو افسانہ۔۔۔ موضوعات و ارتقا ادب کا انسانی زندگی سے گہرا تعلق ہے۔ادب صرف معاشرتی زندگی کا عکاس ہی نہیں بلکہ اس میں زندگی کی نا ہمواریوں کا دکھ اور شخصی اور اجتماعی زندگی کا عکس بھی ملتا ہے۔’’ادب‘‘زندگی سے جنم لیتا ہے۔ ایک کے بغیر دوسرے کا تصور نا ممکن ہے۔ معاشرے میں رو نما ہونے والے سارے عناصر ادب پر اثرانداز ہوتے ہیں۔افسانے میں ایک طرف تخلیق کار کی ذات کا پتہ چلتا ہے تو دوسری طرف اس سے انسانیت کی اعلیٰ اقدار بھی جھلکتی ہیں۔ادب معاشرے کی تعمیر و ترقی میں اہم کردار ادا کرتا ہے اور سماجی، تہذیبی اور فکری رجحانات و میلانات پر اثر انداز بھی ہوتا ہے۔ ادب معاشرے کا آئینہ اور ترجمان ہے جوتمام حقیقتوں کو من وعن پیش کرتا ہے۔ یعنی ادب ہی کے ذریعہ سے کسی بھی بستی، علاقے،خطے،یا ملک و قوم کے باشندوں کی ثقافت،رہن سہن، اطواراور ان کی بودوباش کا علم ہوتا ہے۔ یہ ادب ہی ہے کہ جس کی بدولت کسی بھی قوم کے رہنے والوں کے مجموعی انداز فکر کا اندازہ لگایا جا سکتا ہے۔ ادب اور زندگی ایک دوسرے کے لئے لازم و ملزوم ہیں۔دونوں کو ایک دوسرے سے جدا نہیں کیا جا سکتا۔ابولخیر کشفی ادب کے متعلق لکھتے ہیں: ’’ادب کے وسیلے سے مختلف سماجوں اور معاشروں نے اپنے مجموعی اندازِ فکر،مختلف رویوں اپنی ثقافت اور اپنے شعور کا اظہار کیا ہے۔ادب کو ہر مہذب معاشرے نے نہ صرف گہری توجہ کا مستحق ہی نہیں سمجھا بلکہ ادب کے آئینے میں اپنے بطون کو پیش کیا ہے۔‘‘(1) افسانہ جدید ادب کی ایک صنف ہے۔جس میں افسانوی انداز میں حقیقی واقعات کو بیان کیا جاتا ہے۔یہ ناول کے مقابلے میںخاصا مختصر ہوتا ہے۔افسانے میں ناول کی طرح کہانی کو پھیلایا نہیں جاتا بلکہ مختصر طور پر پیش کیا جاتا ہے۔ افسانے سے...
During Zulfiqar Ali Bhutto's term as Prime Minister, the law and order situation deteriorated throughout the country in general, and in the provinces of NorthWest Frontier Province (now Khyber Pakhtunkhwa) and Balochistan in particular. For multiple reasons, the mutual distrust between Zulfiqar Ali Bhutto and the political leaders of the respective provinces never allowed them to overcome their personal and party interests and establish a harmonious working relationship. Accusations of conspiracy, worsening law and order, and political assassinations, were the dilemmas that agitated the whole country. One of the victims of the political assassination was Hayat Muhammad Khan Sherpao, a leading activist of the Pakistan People's Party and former Governor of Khyber Pakhtunkhwa. The incident of his murder commenced the series of legal disputes and cases of treason filed against the opposition leaders in courts and tribunals, which marred the political scenario of the country till the very end of the Bhutto era. The lack of research on political assassinations in Pakistan is a crucial oversight, especially considering the frequency of the phenomenon and its implications. This study attempts to highlight the main theoretical and political implications of assassinations and identifies some promising directions for further research, in the hope that this unique type of political violence will be better understood in the future.
A survey of five pear growing districts of Azad Jammu and Kashmir i.e. Rawalakot, Bagh, Muzaffarabad, Sudhnoti and Kotli was conducted during the year 2003 and 60 accessions of distinct characters of horticultural importance were selected from 48 sites of these districts for characterization. For each accession, passport data were collected with the help of Pyrus descriptor as developed by International Board of Plant Genetic Resources. During the next two years (2004 and 2005), all the selected accessions were visited thrice each year at the time of flowering, fruit setting and fruit maturity. Data were recorded on growth habit of plants, incidence of diseases (fire blight and apple scab), precocity, intensity of flowering, fruit setting, productivity, time of ripening, fruit shape and fruit colour. Leaves and fruit of these accessions were also collected and leaf area, fruit size and fruit weight were measured. Ripe fruit were evaluated for organoleptic parameters, nutritional value (TSS, total sugars and vitamin C content) and postharvest life at ordinary room temperature (26 ± 2 oC). The accessions differed for these parameters; however, the accessions with the same local name had almost similar characteristics. All the accessions locally called as Frashishi and Desi nashpati had the excellent fruit quality and can be exploited for commercial production in the area. Most of the other accessions, also had good fruit quality except few (locally called as Btangi, Btung, Raj btung and Pathar nakh), which are mostly used as rootstocks in the area. The accessions were characterized by using protein markers based on bio-chemical analysis (SDS-PAGE). The accessions differed in number of bands which ranged from 12- 20. According to the banding pattern the accessions were divided into the various groups and sub-groups showing similarities and differences among them. Out of sixty local xxaccessions, fifty six accessions along with eight varieties (used as reference control) were also characterized using DNA based SSR markers to assess genetic diversity and relationship among them. Nine out of 12 primers revealed clear and reproducible amplification banding pattern in 41 genotypes (33 accessions and 8 control varieties). Cluster analysis based on UPGMA dendrogram, grouped the genotypes into clusters sub- clusters and groups on the basis of relatedness and variability. Most of the accessions were absolutely homogenous and were classified into two homogenous groups, despite the fact that these accessions differed in there morphological and physico-chemical traits. Attempts were also made to preserve the local pear germplasm through in vivo and in vitro methods. For in vivo preservation, a nursery was established and nine pear genotypes i.e. Khurolli, Bagugisha, Pathar nakh, Desi nakh, Kotharnul, Desi nash, Frashishi, Kashmiri nakh and Raj btung were propagated through whip grafting on Btangi seedlings. The genotypes differed for growth parameters. Apical shoots of nine pear genotypes (already mentioned above except Desi nash but including Btangi) were preserved in vitro under minimal growth conditions using low temperature treatments, modification in medium strength and adding mannitol in the basal medium and also by reducing the concentration of BAP and using growth retardants for different storage periods i.e. 3, 6, 9 and 12 months. The genotype differed significantly for survival and regeneration percentages. Storage at 5 °C, MS medium containing 2.5% mannitol and MS medium with reduced concentration of BAP (0.50 mg l -1 ) were found significantly better as compared to other treatments. Storage for the minimum period (3 months) was better than other storage periods as assessed on the basis of survival and regenerability of the cultures.