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Synthesis, Characterization and Biological Screening of Some New N and O Containing Heterocyclic Compounds

Thesis Info

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Author

Tariq Mahmood Babar

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2013

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/2372/1/2830S.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727514002

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The derivatives of isocoumarins, coumarins and 1,2,4-triazoles are prominent biological agents used as a cure against a number of human ailments. The present work deals with their synthesis. 3-(Halobenzyl)isocoumarins (5a-i) were synthesized by condensation of 2-(halophenyl)acetyl chlorides (3a-i) with homophthalic acid (4) at elevated temperature. 3-(Halobenzyl)isocoumarins (5a-i) were converted into 3-(halobenzyl)-3,4- dihydroisocoumarins (8a-i) via ketoacids (6a-i) and hydroxyacids (7a-i). 3- (Halobenzyl)isocoumarins (5a-i) converted to their thio analogues (10a-i) by treating with Lawesson’s reagent (11) while their nitrogen analogues (12a-i) were obtained by passing ammonia into the solution of 3-(halobenzyl)isocoumarins (5a-i) in 2-ethoxy ethanol. These synthesized compounds were evaluated for urease inhibition and anti- inflammatory activity. 3-(Halobenzyl)isocoumarins (5a-i) and ketoacids (6a-i) exhibited moderate urease inhibition activity. While others showed non significant activity. The isoquinolinone (12c) showed anti-inflammatory activity higher than standard compound i-e indomethacin while all other compounds showed non significant anti-inflammation. Reaction of hitherto unknown 4-chloro-3-(2,2,2-trifluoroacetyl)-2H-chromen-2-one (16a) with different commercially availble anilines (19a-l) gave respective 3-(trifluoroacetyl) - 4-(arylamino)-2H-chromen-2-one (20a-l) which were then successfully cyclized to 7- (trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones (21a-l) using conc. H2SO4. The synthesis of 4-aryl-3-(trifluoroacetyl)-2H-chromen-2-ones (18a-n) was accomplished by Suzuki coupling reaction of 4-chloro-3-(2,2,2-trifluoroacetyl)-2H-chromen-2-one (16a) and aryl boronic acids (17a-n). Synthesis of 1,2,4-triazoles (31a-o) was carried out by dehydrative cyclization of thiosemicarbazides (20a-o) which in turn were synthesized by addition of hydrazides (29a-i) on isothiocyanate (27m-n). These triazoles showed moderate antibacterial activity. Finally the synthesized 1,2,4-triazoles (31a-o) were evaluated for their toxicity and these showed low toxicity.
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پروفیسر خواجہ احمد فاروقی

پروفیسر خواجہ احمد فاروقی
جنوری کا معارف مرتب ہوچکا تھا کہ یہ اندوہ ناک خبر ملی کہ اردو کے مشہور محقق و نقاد صف اول کے ادیب اور صاحب طرز انشاء پرداز پروفیسر خواجہ احمد فاروقی ۳۱؍ دسمبر کو رحلت فرماگئے۔ اِنا ﷲ وَاِنا اِلیہ رَاجِعونْ۔
خواجہ صاحب کا خاندان علم و فضل اور سلوک و تصوف میں ممتاز تھا، انھیں انگریزی تعلیم دلائی گئی مگر اس کے باوجود بھی وہ شرافت، وضع داری اور اپنی دیرینہ خاندانی روایات کے حامل تھے۔
۱۹۱۷؁ء میں وہ بچھراؤں ضلع مراد آباد میں پیدا ہوئے، ۱۹۲۷؁ء میں گورنمنٹ ہائی اسکول ہردوئی کی پانچویں جماعت میں داخلہ لیا، یہاں ان کے والد سررشتہ دار تھے، ۱۹۳۲؁ء میں اعلیٰ تعلیم کے لیے میرٹھ کالج میں داخل ہوئے، تعلیم مکمل کرنے کے بعد معلمی کے پیشہ سے وابستہ ہوئے جس کا آغاز مسلم یونیورسٹی اسکول میں کیمسٹری کے استاد کی حیثیت سے کیا، پھر بعض کالجوں سے وابستہ رہنے کے بعد ۱۹۴۶؁ء میں دہلی کے اینگلو عربک کالج میں اردو کے لکچرر ہوئے، جس کے بعد دہلی ہی میں بودوباش اختیار کرلی، خود رقمطراز ہیں:
’’اس وقت سے کہ چالیس سال ہوگئے ہیں، دلی کاروڑا ہوں اور یہ دلی کی گلیاں کسی طرح نہیں چھٹتیں‘‘۔
حزیں از پائے رہ پیما بسے سرگشتگی دیدم
سرشوریدہ بربالین آسایش رسید ایں جا
۱۹۴۸؁ء میں دلی میں چاروں طرف آتش زنی، غارتگری اور قتل عام مچا ہوا تھا اور موج خوں سروں سے گزر رہی تھی، مگر خواجہ صاحب اس قلزم خون کے شناور بنے رہے۔
وہ بچپن ہی میں مطالعہ اور کتب بینی کے عادی ہوگئے تھے اور تقریر و تحریر کی مشق بھی شروع کردی تھی، ہردوئی ہائی اسکول میں جب زیر تعلیم تھے تو غنچہ (بجنور) اور پھول (لاہور) کے لیے مضامین لکھتے رہتے تھے۔ اسی زمانے میں اپنے ایک ہم جماعت کے اشتراک...

An Appraisal of the Degree of School Effectiveness among Secondary Schools of Zamfara State, Nigeria

This study was conducted purposely to assess the degree of school effectiveness among public secondary schools of Zamfara State, Nigeria. In order to achieve this fundamental objective, one research question was formulated. A descriptive survey research design was adopted in the study. Population of the study comprised the entire 2361 classroom teachers deployed in the 158 public secondary schools of Zamfara State-Nigeria. From the population of the study, a sample size of 266 teachers was extracted using a ‘Multistage Random Sampling Technique’. A semi-structured questionnaire developed by Lezzote and Snyder (2011) on a five Likert type scale instrument with 21 items was employed as an instrument for data collection. The instrument composite reliability was computed using Cronbach’s alpha method and obtained the value of .949. All data covered in the study were collected through a field survey approach. Analytically, the current study discovered that, the degree of school effectiveness was at a high extent with mean score (M=3.68, SD=0.15). Based on this finding, the paper recommends that, stakeholders in educational sector comprising government’s ministries, departments and agencies, policymakers, secondary schools’ principals, instructional teachers as well as the learners and their parents/guardians should reciprocally work together in the process of appropriate perpetration and advancement of effective school system and its practices.

Developing an Enhanced Risk Management Framework for Banking Industry of Pakistan Using a Qualitative Approach.

The purpose of this study is to conduct an in-depth analysis of the existing risk management framework (RMF) to find out the shortcomings in each phase of risk management process and risk governance issues in the commercial banking industry of Pakistan. A qualitative research design was adopted for this study to carry out the indepth evaluation of the existing RMF. A case study based research strategy was adopted in which in-depth interviews were conducted from the CROs/Heads of Risk, Head of Market, Head of Credit Risk of commercial banks of Pakistan as well as from SBP employees of RMD and BPRD division. Data was collected at one point of time so this was a cross sectional study. Data analysis was done using a technique called thematic analysis using QSR-Nvivo 11. In thematic analysis, the data collected through interviews were coded under relevant nodes. Then themes are extracted from the nodes using word cloud and word trees. The thematic analysis reveals that there are certain deficiencies in the existing RMF. Firstly, ineffectiveness of board risk oversight is due to absence of risk expert on the BRMC, lack of risk knowledge and experience, quality, quantity and timeliness of risk information, and dysfunctional behavior of executive management. Secondly, incorrect positioning of CRO is due to lack of peer status, reporting line, sole responsible of risk management, and limited to compliance function only. Thirdly, lack of maturity of risk management capabilities is due to lack of certified risk talent and risk trainings; lack of advanced e-risk solution, unavailability of tested and validated risk models, and repeatable or define state of maturity. Fourthly, weak risk culture and lack of risk awareness towards risk policy for effective risk understanding; risk identification framework for effective risk identification; e-risk software solutions; advanced risk techniques and tested risk models for effective risk assessment & analysis; inefficient information & reporting system for effective risk monitoring & controlling. Lastly, there is a lack of risk training, workshops and seminars a on the part of SBP to facilitate banks in the adoption of latest regulations and techniques such Basel III etc. It is recommended that the SBP should increase their risk training programs so that the adoption of new risk standards like Basel III will become smooth. Moreover, it is suggested that the Board of Directors (BoDs) and executive management take steps to improve the capability and maturity of the risk management function by introducing tested and validated risk models, risk certification e.g. FRM etc., advanced e-risk software solutions e.g. SAS etc., and internal risk trainings, workshops and seminars. These initiatives will improve the strength, capability and maturity of the risk management function and makes the banks more secure and profitable. Furthermore, it is suggested that the BoDs design policies to create a risk culture in the bank so that every person in the bank will understand the importance of risk management that could lead to correct the positioning of CROs in the banks so that the CROs can play their part in the most effective way. This study is the first one to apply the thematic analysis on the qualitative data in the risk management area. Previous studies do not cover the risk management framework and risk governance problems whereas the present study consider the indepth evaluation of the existing risk management framework in commercial banking industry of Pakistan and the results are beneficial for many stakeholders such as SBP, BoDs, BRMC, ERMCs and CROs.