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Home > Synthesis, Characterization and Biological Studies of Ferrocenyl Ureas & Thioureas

Synthesis, Characterization and Biological Studies of Ferrocenyl Ureas & Thioureas

Thesis Info

Access Option

External Link

Author

Altaf Ali Altaf

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/220

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727514299

Similar


Series of ferrocene substituted organometallic thioureas and ureas of general formula [C 5 H 5 FeC 5 H 4 C 6 H 3 (R)NHC(X)NHR`] where, R = H, CH 3 , OCH 3 or Cl, R` = alkyl/aryl groups and X = O or S, have been synthesized and characterized by using elemental analysis, FT-IR, multinuclear ( 1 H and 13 C) NMR spectroscopy and UV-Visible spectroscopy. Single crystal XRD was used for structural elucidation of some of the synthesized intermediate and end products. In all crystal structures free cyclopendienyl (Cp) ring found to be disordered over two sets of atoms. Based on the single crystal X-ray analysis most of the synthesized compounds were found to be stabilized by intermolecular as well as intramolecular hydrogen bonding and secondary non-covalent interactions. These intermolecular interactions permeate these molecules to form supera-molecular structures. The synthesized intermediates and the end products were studied for the interaction with modal bio-mimetic micelle membranes by probing with 1 H-NMR and UV-Visible spectroscopy. Membrane penetration studies have been carried out for some compounds with model lipid membrane interfaces prepared from SDS and TTAB surfactants using 1 H NMR and UV-Vis spectroscopic techniques. Results show the presence of these molecules in the interfacial regions of the self assembled systems. These studies justify the lipophilic character of these compounds as their ability to penetrate into the modal membranes. Primarily these compounds were screened for their DNA binding behavior and antioxidant activity to evaluate their anti-cancer potency. Ferrocenyl ureas exhibited better anti-oxidant activity than the respective thioureas in general and compound B u 6 was found to be the most active with IC 50 = 11.94 ± 0.05 μM (IC 50 for standard thiourea is 30.53 ± 0.1 μM). DNA binding studies based on UV-Visible spectrophotometric titration shows the potential of these organometallic compounds as an anti-cancer agents. In ferrocenyl thioureas, the induction of nitro group found to increase the binding ability of these compounds with DNA in these titrations. And E t 6 was found to be the most interacting compound among the tested ones with binding constant of Kb = 10810 M -1 .
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درشن

درشن

مائے نی جہلم جاون دے
پیا نوں دکھ سناون دے

پیا بناں میں ریہہ نہ سکدی
ہر دم اوہدیاں راہواں تکدی
تک تک راہواں کدی ناں اکدی
دل دا شوق نبھاون دے
مائے نی جہلم جاون دے

مدتاں ہوئیاں ملن نہ ہویا
دل رہندا اے کھویا کھویا
اکھیاں ہنجواں ہار پرویا
اے مالا گل وچ پاون دے
مائے نی جہلم جاون دے

پہاڑ ٹلے دا نظریں آوے
جے کر سوہنا تلک لگاوے
گجھڑا روگ اندر دا جاوے
دارو عشق دا کھاون دے
مائے نی جہلم جاون دے

دلبر نے جدوں مکھ دکھلایا
سب کچھ بھلیا، ہوش گنوایا
مئے نوشی وچ سب کجھ پایا
دل دی پیاس بجھاون دے
مائے نی جہلم جاون دے

جہلم شہر دے کریں نظارے
جتھے رہندے دلبر پیارے
قادری اوتھے چین قرار اے
اج رج کے درشن پاون دے
مائے نی جہلم جاون دے

تولیدی اور جنسی صحت: اسلامی تعلیمات کی روشنی میں

Human is the combination of body and spirit, Islām pays attention to the balanced growth and construction of the human personality considering the health of both body and spirit. As Muslims, we believe that Islām is the perfect code of life, which provides guidance for the solutions of all individual and collective problems of human beings. Therefore, we believe that Islām has a complete system of instructions for the development and reformation of spirit on the one hand, and, on the other hand, it has prescribed guidelines for the upkeeping and maintenance of the body. Reproductive and sexual health is one of the major problems of human beings. Eastern societies are comparatively shy to discuss this problem, unless necessary, while the western societies have introduced sex education in their schools to teenagers. We being Muslims tend to look towards our religion to guide us in such a way, that it may educate us, on the one hand, and on the other, it may guide us to adopt the required attitude to avoid the negativity of its awareness. Although the issue of reproductive health is considered as the specialty of the modern age, however, Islamic instructions very obviously discuss them from the beginning. In this article, the author has explored and elaborated Islamic teachings regarding the reproductive health and sexual instructions and discussed them in order to prove that Islām has the full capacity to solve the current social problems of reproductive health and sexual health.

Key Management in Wireless Sensor Networks

Wireless sensor networks(WSNs) consist of a large number of low power nodes, with limited processing, communication, and storage resources. Large scale wireless sensor networks (WSNs) are highly vulnerable to attacks because they consist of numerous resource constrained devices communicating via wireless links.The standard security requirements in WSNs include confiden- tiality, authentication and availability. These security requirements can be provided by encryption and authentication services which in turn demands a comprehensive key management scheme. The goal of key management is to pre-distribute cryptographic keys or keying materials among the nodes prior to the deployment, revoke keys if nodes leave the network, assign new keys to the nodes joining the network and periodically refreshing the keys. However, providing key manage- ment in WSNs is difficult due to the unknown network topology prior to deployment, intermittent connectivity and resource limitations of the sensor network environment. Key management schemes consider hierarchical HSN consisting of a small number of high-end sensors (H-node) and a large number of low-end sensors (L-node). A key generation process is incorporated, where instead of generating a large pool of random keys, a key pool is represented by a small number of generation keys, in order to address storage overhead problem in the con- straint sensor nodes. For a given generation key and a publicly known seed value, a keyed-hash function generates a key chain; these key chains collectively make a key pool. In the scheme proposed, after discovering the shared pairwise keys with neighbors, all H-node and L-node de- stroy their initial key rings and generate new key rings by applying one-way hash function on node’s ID and initial key ring. As a consequence, new nodes can still be added in the network beyond the initial deployment even after the deletion of initial key rings from nodes memory. In addition, a self-healing group key distribution scheme is developed for secure multicast commu-nications in HSN environment. This scheme presents a strategy for securely distributing rekeying messages and specifies techniques for joining and leaving a group. Access control in multicast system is usually achieved by encrypting the content using an encryption key, known as the group key (session key) that is only known by the group controller and all legitimate group members. In proposed scheme, all rekeying messages, except for unicast of an individual key, are transmitted without any encryption using one-way hash function and XOR operation. Further, nodes are capa- ble of recovering lost session keys on their own, without requesting additional transmission from the group controller. Also the time-limited node revocation is achieved without any intervention from the GC. This research reports the implementation and the performance of the proposed schemes on Cross- bow’s MicaZ motes running TinyOS and evaluates the computation and storage costs of two keyed-hash algorithms for key chain generation, HMAC-SHA1 and HMAC-MD5. The results show that proposed scheme can significantly reduce the storage requirements as compared to other random key pre-distribution schemes. The performance analysis of the collusion resistant mechanism shows that even if a large number of nodes are compromised, an adversary can only exploit a small number of keys nearby the compromised nodes, while other keys in the network remain safe. Also, the resiliency against node capture is better than previous key pre-distribution schemes. The security analysis of secure group key distribution scheme shows that the proposed scheme is computationally secure and meets the security requirements for forward and backward secrecy.