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Home > Synthesis, Characterization and Biological Studies of Novel Guanidines and Their Complexes

Synthesis, Characterization and Biological Studies of Novel Guanidines and Their Complexes

Thesis Info

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Author

Murtaza, Ghulam

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2011

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/730

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727514871

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Two series of substituted guanidines (a 1 -a 32 & b 1 -b 32 ) and their copper(II) complexes of general formula [κ 2 (O, N)-C 6 H 5 CONHC(NHR 1 )NR 2 ] 2 Cu(II) where, R 1 = phenyl (A 1 - A 32 ), 2-chlorophenyl (B 1 -B 32 ) and R 2 = alkyl/aryl groups, have been synthesized and characterized by using elemental analysis, FT-IR, multinuclear ( 1 H and 13 C) NMR spectroscopy and magnetic susceptibility measurements. Single crystal XRD was used for structural elucidation of some of the synthesized guanidine ligands and their copper(II) complexes. Based on the single crystal X-ray analysis most of the synthesized guanidine ligands were stabilized by intermolecular as well as intramolecular hydrogen bonding. All the complexes are mononuclear in solid state and copper adopts a regular square planar geometry with slight distortion in few cases, while N,N'',N"-trisubstituted guanidine ligands chelate the Cu(II) atom through oxygen and nitrogen with ligand to metal ratio 2:1. DFT studies have been used to assess the location of the protons in free ligands, however calculations have shown that in all cases, hydrogen bonding from either of the N-H groups gives conformations that are very similar in energy. The synthesized guanidines and their complexes were also screened for urease inhibition, antileishmanial, anticancer and antifungal activities. The complexes exhibited a better usease inhibition activity than the respective guanidines and compound A 7 was found to be the most active with IC 50 = 4.8 ± 0.05 μM (IC 50 for standard thiourea is 21.0 ± 0.1 μM). These compounds were also screened for their brine shrimp lethality assay, a 1 and A 28 were found to be more toxic with the ID 50 value 1.701 ppm. In potato disc antitumour assay guanidines and complexes have shown the excellent activity comparable with the vincristine, used as standard drug while, in vitro cytotoxicity against human cell lines carcinomas A498, EVSAT, H226, IGROV, M19, MCF-7 and WIDR these compounds show moderate cytotoxicity against these cell lines as compared to the standard chemotherapeutic drugs. These compounds were also tested for antifungal and antileishmanial activities and show moderate to good antifungal activity but no significant antileishmanial activity.
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سید عبدالدائم الجلالی

آفتاب علم وفضل غروب ہوگیا
[سید عبدالدائم الجلالی]
۵/نومبر۱۹۸۳ء شنبہ کے روزساڑھے بارہ بجے دن بذریعہ ٹیلیفون عزیزم سید نجم السلام میاں کی زبانی اس خبر ِوحشت اثر سے کہ استاذی علامہ سیدعبد الدائم الجلالی مفسر قرآن کریم داغ مفارقت دے گئے، قلب ودماغ کوسخت صدمہ پہنچا۔
مولانا سید عزیز عبدالدائم صاحب جلالی مرحوم ۱۹۰۱ء میں رام پور میں پیدا ہوئے۔ وہیں تعلیم حاصل کی، اوررام پور ہی کی قدیم وعظیم علمی درسگاہ مدرسہ عالیہ میں تقریباً۲۵ سال مدرس وپرنسپل رہے۔
مصطفی آباد عرف رام پور پٹھانوں کی ایک چھوٹی سی ریاست تھی، لیکن علم و فضل کے اعتبارسے ایک قدآور شہر تھا،اورایک زمانے میں بخارائے ہند کے نام سے مشہور تھا، یہ عظیم خطہ علماء،شعراء،اطباء وصوفیاء اورعظیم سیاسی لیڈروں کا مولد و مسکن رہا ہے۔
علامۂ عصر محقق زمانہ مولاناعبدالعلی بحرالعلوم فرنگی محلی فرزند مولانا نظام الدین سہالوی مؤسس درس نظامی، رام پور کی شہرۂ آفاق درس گاہ مدرسہ عالیہ کے پہلے پرنسپل مقرر ہوئے تھے۔ اور مشہور منطقی وفلسفی ملامحمدحسن جن کی شہرۂ آفاق منطق کی کتاب’’ملاحسن‘‘جوہندوپاک کی ہر بڑی عربی درس گاہ میں داخل نصاب ہے مدرسہ عالیہ رام پور میں مدرس رہے اوررامپور ہی میں پیوند خاک ہوئے۔
اولیاء اﷲ میں مقتدائے مشائخ حضرت سید عبداﷲ شاہ بغدادی رحمۃ اﷲ علیہ، اور مشہور بزرگ حافظ شاہ جمال اﷲ علیہ الرحمۃ نے بھی رام پور ہی کو اپنا مسکن بنایا اور ہر دو بزرگوں کی آخری آرام گاہ بھی رامپور ہی ہے۔ اول الذکر بزرگ کے بغداد سے دہلی پہنچنے پر مشہور نقشبندی و مجددی بزرگ حضرت میاں مظہر جانجاناں اور سلسلۂ چشتیہ نظامیہ کے مجدد حضرت مولانا فخر الدینؒ نے موصوف کی پالکی کو کاندھا دیا تھا۔
شیخِ شیوخ العالم امام الصوفیاء شاہ احمد سعید مجددی کا وطن بھی رامپور ہی ہے، جن کے مریدین و خلفاء میں عرب و عجم...

Comparative Analysis of Islamic Banking Products in Pakistan and Malaysia

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