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Home > Synthesis, Characterization and Pharmacological Evaluation of Some 1, 2, 4-Triazole, 1, 3, 4-Oxadiazole, Triazolothiadiazole and Indolinone Derivatives

Synthesis, Characterization and Pharmacological Evaluation of Some 1, 2, 4-Triazole, 1, 3, 4-Oxadiazole, Triazolothiadiazole and Indolinone Derivatives

Thesis Info

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Author

Hanif, Muhammad

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/2173

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727517565

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The work presented in the thesis consists of the synthesis, characterization and pharmacological evaluation of nitrogen-containing heterocyclic compounds. For convenience, the research work presented in this thesis has been divided into four chapters. The first chapter includes, the synthesis, characterization and pharmacological evaluation of 4,5- disubstituted-1,2,4-triazole-3-thiones and 4,5-disubstituted-1,2,4-triazole-3-ones. Both of these target compounds were synthesized by four-step syntheses involving a series of reactions, including esterification of substituted aromatic acids, hydrazide formation and their condensation with substituted isothiocyanates and substituted isocyanates resulting in the formation of thiosemicarbazides and semicarbazides. The former were obtained by refluxing thiosemicarbazides in sodium hydroxide solution (4N) and the latter were formed by refluxing semicarbazides in sodium hydroxide solution (2N). The final products were obtained by neutralizing the reaction mixtures with dilute hydrochloric acid solution. Later on, the synthesized compounds were screened for their antifungal, anti-inflammatory, acetylcholinesterase, alkaline phosphatase and -glucoronidase activities. The second chapter includes the synthesis, characterization and pharmacological evaluation of 1,3,4-oxadiazoles. These compounds were synthesized by refluxing aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide. All of these compounds were checked for their cytotoxic activities using three different cell lines. The third chapter includes the synthesis, characterization and pharmacological evaluation of triazolothiadiazoles-substituted bridged heterocycles. The synthesis involves the formation of 5- substituted-4-amino-1,2,4-triazole-3-thiones by stirring different aromatic hydrazides with carbon disulfide in methanolic potassium hydroxide and resulted in the formation of potassium dithiocarbazinate salts, which on refluxing with hydrazine hydrate, yielded 5-substituted-4- amino-1,2,4-triazoles-3-thiones. Triazolothiadiazoles were formed by refluxing different aromatic acids with 5-substituted-4-amino-1,2,4-triazoles-3-thiones in phosphoryl chloride. All the synthesized compounds were screened for antibacterial, acetylcholinesterase and alkaline phosphatase activities. The fourth chapter addresses the synthesis, characterization and pharmacological evaluation of Schiff bases of isatin, which are known as indolinone derivatives. These compounds were synthesized by the reaction of acid hydrazides with substituted isatins in ethanol. The synthesized compounds were screened for cytotoxic activity.
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سید عبدالدائم الجلالی

آفتاب علم وفضل غروب ہوگیا
[سید عبدالدائم الجلالی]
۵/نومبر۱۹۸۳ء شنبہ کے روزساڑھے بارہ بجے دن بذریعہ ٹیلیفون عزیزم سید نجم السلام میاں کی زبانی اس خبر ِوحشت اثر سے کہ استاذی علامہ سیدعبد الدائم الجلالی مفسر قرآن کریم داغ مفارقت دے گئے، قلب ودماغ کوسخت صدمہ پہنچا۔
مولانا سید عزیز عبدالدائم صاحب جلالی مرحوم ۱۹۰۱ء میں رام پور میں پیدا ہوئے۔ وہیں تعلیم حاصل کی، اوررام پور ہی کی قدیم وعظیم علمی درسگاہ مدرسہ عالیہ میں تقریباً۲۵ سال مدرس وپرنسپل رہے۔
مصطفی آباد عرف رام پور پٹھانوں کی ایک چھوٹی سی ریاست تھی، لیکن علم و فضل کے اعتبارسے ایک قدآور شہر تھا،اورایک زمانے میں بخارائے ہند کے نام سے مشہور تھا، یہ عظیم خطہ علماء،شعراء،اطباء وصوفیاء اورعظیم سیاسی لیڈروں کا مولد و مسکن رہا ہے۔
علامۂ عصر محقق زمانہ مولاناعبدالعلی بحرالعلوم فرنگی محلی فرزند مولانا نظام الدین سہالوی مؤسس درس نظامی، رام پور کی شہرۂ آفاق درس گاہ مدرسہ عالیہ کے پہلے پرنسپل مقرر ہوئے تھے۔ اور مشہور منطقی وفلسفی ملامحمدحسن جن کی شہرۂ آفاق منطق کی کتاب’’ملاحسن‘‘جوہندوپاک کی ہر بڑی عربی درس گاہ میں داخل نصاب ہے مدرسہ عالیہ رام پور میں مدرس رہے اوررامپور ہی میں پیوند خاک ہوئے۔
اولیاء اﷲ میں مقتدائے مشائخ حضرت سید عبداﷲ شاہ بغدادی رحمۃ اﷲ علیہ، اور مشہور بزرگ حافظ شاہ جمال اﷲ علیہ الرحمۃ نے بھی رام پور ہی کو اپنا مسکن بنایا اور ہر دو بزرگوں کی آخری آرام گاہ بھی رامپور ہی ہے۔ اول الذکر بزرگ کے بغداد سے دہلی پہنچنے پر مشہور نقشبندی و مجددی بزرگ حضرت میاں مظہر جانجاناں اور سلسلۂ چشتیہ نظامیہ کے مجدد حضرت مولانا فخر الدینؒ نے موصوف کی پالکی کو کاندھا دیا تھا۔
شیخِ شیوخ العالم امام الصوفیاء شاہ احمد سعید مجددی کا وطن بھی رامپور ہی ہے، جن کے مریدین و خلفاء میں عرب و عجم...

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