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Synthesis, Characterization and Potential Applications of Nitrogen Containing Compounds and Coordination Polymers

Thesis Info

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Author

Saghir Abbas,

Program

PhD

Institute

Quaid-I-Azam University

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Synthesis

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/9316/1/Saghir%20Abbas_Chem_2018_QAU_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727518779

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In the present work, biologically important esters, hydrazides, thiocarbamates, 1,2,4-triazole-3-thiones and Schiff bases have been prepared and characterized by FT-IR, 1H and 13C NMR spectroscopy and SXRD analysis. The prepared derivatives were evaluated for their inhibitory potential against carbonic anhydrase II. Furthermore, to check the cytotoxicity, these derivatives were tested against human breast adenocarcinoma. The experimental results were validated by molecular docking and dynamic simulations of the potent compounds in the active pockets of enzymes. Important binding relations of potent compounds with the important residues in the dynamic sites of the carbonic anhydrase enzyme were disclosed. Moreover, the supramolecular assembly of the 4bs2 compound was analyzed by density functional theory (DFT) calculations. These studies rendered a more clear understanding for the demonstration of novel molecular mechanisms involved in the CA II inhibition by the synthesized compound. The single crystal data for the compounds 2d, 2bs1 and 2bs2 showed that they did not have any π-π or C-H…π interactions while the compound 4bs2 has C-H... π and C-Cl... π interactions that play a vital role. In another study, different types of coordination polymers containing two-dimensional isostructural monometallic structures, metal hexacyanometalates and metal pentacyanometalates were synthesized and characterized. A novel synthetic method to improve the surface concentration of cyanide-based systems involving a pentacyanoferrate containing polymer as a precursor has been adopted. Given the improvement of electrocatalytic activity obtained with the aforementioned system, herein, electrocatalytic activities of a new series of cobalt pentacyanoferrate, Co3[Fe(CN)5L]2, L = pyridine (py), 4-pyridinecarbonitrile (4PC), imidazole (imid), hexamethylenetetramine (HMT),) have been studied in detail to explore the consequence of a N-donor ligand to the structure and, thus, to the electrocatalytic performance. Chronoamperometry studies showed that the said systems exhibit a catalytic current density of 1 mA.cm-2 at overpotentials (η) ranging between 470 – 525 mV, which is lower than that of the previously studied cobalt hexacyanoferrates. Detailed electrochemical analysis including long-term electrolysis has been presented in the current study to evaluate the performances of the catalysts.
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کیویں لائیے جھوٹا لارا

کیویں لائیے جھوٹا لارا
ایہہ بھار ساڈے توں بھارا

توں جے ملنا نہیں سی سجناں
کیوں کیتا ایڈ پسارا

کدی تے سانوں سد مدینے
اے عرب دیا سردارا

دتی جان خدا دے راہ تے
تیرا شاہ حسینؑ پیارا

نہ دے سائل نوں توں دھکے
اپنا رکھ سوہنا ور تارا

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Takaful is the name of alternative system of Conventional Insurance. It deals with the mutual cooperation among all human beings in the society. In Takaful, the frame work of conventional insurance has been designed in the light of religious Precedence. Perhaps the practical types of Takaful is new but not to clash with the basic principles of Islamic Law. In this paper, it has been thoroughly discussed the introduction of Takaful along with Religious Precedence

Mean Estimation in Adaptive Cluster Sampling Using Auxiliary Information

In this dissertation, generalized simple and exponential type estimators have been developed using the information of single and two auxiliary variables for the estimation of rare and clustered population mean in adaptive cluster sampling designs. The proposed estimators are specifically developed for different situations of clustered populations in simple adaptive cluster sampling, stratified adaptive cluster sampling and systematic adaptive cluster sampling designs. In Chapter 1, the discussion has been made about the situations of rare and clustered population in which the conventional sampling designs may not be appropriate in order to achieve even moderate precision. The use of adaptive cluster sampling design along with the process in the presence of auxiliary information is also discussed. Comparison of adaptive cluster sampling with conventional sampling design and some advantages and disadvantages has also been given. 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