Search or add a thesis

Advanced Search (Beta)
Home > Synthesis, Structural and Biological Investigations of Vanadium V Complexes With N and O Donor Ligands

Synthesis, Structural and Biological Investigations of Vanadium V Complexes With N and O Donor Ligands

Thesis Info

Access Option

External Link

Author

Sultan, Sadaf

Program

PhD

Institute

University of Karachi

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/10656/1/Sadaf%20Sultan_Chem_2018_UoK_PRR.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727528082

Similar


In last two decades vanadium coordination chemistry has grasp the interest of chemists due to its importance from catalysis and medicinal point of view. Vanadium plays significant role in different biological systems, actively serving in vanadium dependent haloperoxidase and nitrogenase enzymes. It also exhibits insulin-mimetic (anti-diabetic) activity. The present study is carried out in order to synthesize new vanadium (V) complexes with N and O donor hydrazide ligands and reveal their biological importance in terms of antioxidant activities and different enzyme inhibition activities. On the basis of spectral, elemental and physical data, synthesized vanadium (V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. In synthesized vanadium (V) complexes hydrazides act as bidentate ligands and are found to be attached with O of C=O and N of NH2, and these attachments are evident from IR and NMR spectra of these complexes. The inhibitory potential of vanadium (V) complexes of hydrazides against oxidative enzymes including xanthine oxidase and lipoxygenase is determined. In addition, non-enzymatic radical scavenging activities of these complexes were also determined. Results show that hydrazide ligands (1-12) and their respective vanadium (V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and lipoxygenase, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. It is interesting that V(V) complexes are more active for all enzymatic and radical scavenging studies reported here except for lipoxygenase enzyme which demonstrates the difference in the interaction of metal complexes with metalloenzymes. Furthermore enzyme inhibition potential of all the synthesized ligands, metal salt and vanadium (V) hydrazide complexes has also evaluated against tyrosinase, urease and carbonic anhydrase enzymes. Results obtained during the course of this study reveal that hydrazide ligands show moderate inhibition against tyrosinase, but found to be inactive against urease and carbonic anhydrase enzymes. Vanadium (V) hydrazide complexes show variable degree i.e. excellent, moderate to weak activity against all of these studied enzymes. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds and demonstrate the difference in the interaction of metal complexes with metalloenzymes. Further pharmacological and toxicological studies are required to evaluate the bioactive vanadium complexes to find out their potential for use as drugs.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

آیاتِ قرآنی کے اسرار و حکم

آیاتِ قرآنی کے اسرار و حکم

قرآن ِ مجید میں متعدد مقامات پر مختلف اسمائے استفہامیہ کا استعمال کیا گیا ہے جو مختلف مقاصد کے پیش نظر بیان ہوئے ہیں، ذیل میں اہم اسمائے استفہامیہ کے استعمالات اور مقاصد و ضرورت کو بیان کیا جاتا ہے:

اسم ِ استفہامیہ :مَن (کون) عاقل کے لیے استعمال ہوتا ہےارشارِ ربانی ہے:

"مَنْ يَّاْتِيْكُمْ بِمَاءٍ مَّعِيْنٍ"۔ [[1]]

"کون ہے جو اس پانی کی بہتی ہوئی سوتیں تمہیں نکال کر لادے گا ؟ "۔

یعنی کیا خدا کے سوا کسی میں یہ طاقت ہے کہ ان سوتوں کو پھر سے جاری کر دے؟ اگر نہیں ہے، اور تم جانتے ہو کہ نہیں ہے، تو پھر عبادت کا مستحق خدا ہے، یا تمہارے وہ معبود جو انہیں کاری کرنے کی کوئی قدرت نہیں رکھتے؟ اس کے بعد تم خود اپنے ضمیر سے پوچھو کہ گمراہ خدائے واحد کو ماننے والے ہیں یا وہ جو شرک کر رہے ہیں؟

اسم ِ استفہامیہ :أي (کونسا) عاقل اور غیر عاقل دونوں کے لیے استعمال ہوتا ہےارشارِ ربانی ہے:

"اَيُّكُمْ اَحْسَنُ عَمَلًا "۔[[2]]

اللہ تعالیٰ نے یہاں یہ نہیں فرمایا کہ کون زیادہ عمل کرتا ہے بلکہ فرمایا کون زیادہ اچھے عمل کرتا ہے۔ اس لیے کہ اچھا عمل وہ ہوتا ہے جو صرف رضائے الہی کی خاطر ہو اور دوسرا یہ کہ وہ سنت کے مطابق ہو ۔ ان دو شرطوں میں سے ایک شرط بھی فوت ہو جائے گی تو وہ اچھا عمل نہیں رہے گا، پھر وہ چاہے کتنا بھی زیادہ ہو، اللہ کے ہاں اس کی کوئی حیثیت نہیں ۔

...

عناية أئمة النقد الحديثي بفقه الحديث

It is generally perceived in contemporary intellectual movements that canonical Traditionalists did not take had฀th text into consideration as their scholarly efforts were limited to the evaluation of had฀th chains. Aforementioned notion - in my opinion - originates from shallow study of methodology adopted by canonical had฀th critics، as a deeper look into their scholarly works reveals that sciences of had฀th includes the authentication and disparagement of traditions as well as comprehension and deduction from had฀th content. The sole objective of early Traditionalists from transmission، collection of had฀th، its evaluation، authentication and disparagement was to safeguard the true meaning of Sunnah and to transmit it in its pure form to the successors. In fact the peculiarity of their work is that they exert all efforts in order to deal with had฀th as a single undivided whole، where examination of content was not irrelevant to the evaluation of chain، their conscientious efforts recorded in major works of had฀th show how they evaluated content of had฀th to determine that it was not contradictory to Shari‘ah، or with another sound tradition، as there was a possibility that a certain reliable reporter made mistake or speculated in transmitting the meaning of had฀th. Therefore we witness them disparaging a certain transmitter for his negligence and errors whereas his had฀th is forsaken، moreover they would not consider him a Traditionalists or muhaddith฀n if excessive speculations were found in his report. This research paper aims at investigating the aforementioned hypothesis.

Biochemical Profile of Milk from Oxytocin Injected Buffaloes

Milk is a lacteal secretion obtained by milking of healthy animals in its natural form, free from colostrum contains a highly rich source of energy, protein, fats, minerals, trace elements, vitamins, enzymes and others. Oxytocin, a hormone, released by pituitary gland into the blood, stimulates the secretion of milk and is bound with myoepithilial cells to induce the contraction of mammary gland resulting the expulsion of milk into the milk ducts (let down). The use of exogenous oxytocin is increasing day by day in Pakistan, which could affect the consumer’s health and milk constituents. Selected breed of buffaloes (Nili Ravi) is the best dairy animals existing in Pakistan, with good milk production. Milk of 24 Nili Ravi buffaloes were collected fortnightly fromcontrol and oxytocin treated samples from Tarir Dairy Farm, Dhanola. The samples were analyzed to determine changes in composition, enzyme activity, fatty acids, vitamins and minerals due to oxytocin. Data obtained for each attribute was subjected to statistical analysis.Oxytocin administration to buffaloes resulted in increasedpH, proteins, lactose and solid-not-fat and decreased in fat percent. Alkaline phosphotase, acid phosphotase, lactoperoxidase activity, and thiocyanate were high in oxytocin treated buffaloes while lipase activity was increased in control. Caprylic acid(C 8 ), capric acid (C 10 ), myristic acid (C 14 ), palmitic (C 16 ) were high while butyric acid (C 4 ), caproic acid (C 6 ), lauric acid (C 12 ), steric acid (C 18 ), oleic acid (C 18:1 ), linoleic acid (C 18:2 ) were low in oxytocin treated buffalo. Vitamins (A, D, E and C) were increased in oxytocin treated buffaloes as compared to control. Sodium, phosphorus, copper were increased whereas decrease in potassium, iron and zinc in experimental group. From this study it is concluded that regular oxytocin injections should be discouraged because it not only affect the milk composition but also has a promising effect on health of the consumers.