Home > Synthesis, Structural Elucidation, Biocidal and Preliminary Dna Interaction Studies of Organotin Iv Complexes With [O, O] and [O, N, O] Donor Ligands
Synthesis, Structural Elucidation, Biocidal and Preliminary Dna Interaction Studies of Organotin Iv Complexes With [O, O] and [O, N, O] Donor Ligands
In the present study, thirteen novel [O,O] and [O,N,O] potential donor ligands were synthesized by reaction of salicylaldehyde and substituted salicylaldehyde with tranexamic acid, hydrazides and dihydrazides in ethanol. The di- and triorganotin(IV) derivatives of these compounds have also been obtained in good yields by refluxing the compound or its sodium/triethylammonium salt and the respective organotin(IV) chlorides/oxides/dihydroxidechloride in dry toluene for 8-10 hours. The ligands were 4-((5-bromo-2-hydroxybenzylideneamino)methyl)cyclohexanecarboxylic acid (H2La) 4-((1-(2-hydroxyphenyl)ethylideneamino)methyl)cyclohexanecarboxylic acid (H2Lb), 4-((1-(5-bromo-2-hydroxyphenyl)ethylideneamino)methyl)cyclohexanecarboxylic acid (H2Lc), N′-(2-hydroxybenzylidene)formohydrazide (H2Ld), N′-(5-bromo-2- hydroxybenzylidene)formohydrazide (H2Le), N′-(2-hydroxy-3-methoxybenzylid- f ene)formohydrazide (H2L ), N′-(4-(diethylamino)-2-hydroxybenzylidene)formohyd- razide (H2Lg), N′-(2-hydroxynaphthalen-1-yl)methylene)formohydrazide (H2Lh), N′- (1-(5-bromo-2-hydroxyphenyl)ethylidene)formohydrazide (H2Li), N′-(2-hydroxyben- zylidene)-4-tert-butylbenzohydrazide (H2Lj), N1′, N6′-bis(2-hydroxyben-zylidene)- adipohydrazide (H4Lk), N1′, N6′-bis(5-bromo-2-hydroxybenzylidene)adipohydrazide (H4Ll), N1′, N6′-bis(2-hydroxy-3-methoxybenzylidene)adipohydrazide (H4Lm) and N1′, N4′-bis(2-hydroxybenzylidene)succinohydrazide (H4Ln). A variety of spectroscopic techniques like FT-IR, multinuclear NMR spectroscopy (1H, 13 C and 119 Sn) and mass spectrometry were used to ascertain the structure, coordination mode of ligands and geometry of tin in the synthesized complexes. The solid state structures were also studied by performing single crystal X-ray analyses. The results revealed that in case of [O,O] donor ligands, the coordination to the tin atom is through the COO moiety. The triorganotin(IV) derivatives demonstrate trigonal bipyramidal geometry in the solid and tetrahedral in the solution state with few exceptions. All diorganotin(IV) derivatives with [O,N,O] donor ligands retain their geometry as trigonal bipyramid in solid as well as in solution. The complexes were screened for cytotoxicity, antifungal, antibacterial, antiurease, and leishmanicidal activities. The triorganotin(IV) derivatives of [O,O] donor ligands and dibutyl(IV) complexes in case of [O,N,O] donor ligands exhibit iii reasonable biocidal activities. Most complexes were more active than the corresponding free ligands. The interaction of R2SnLd (R = −CH3, n−C4H9, and −C6H5) with DNA were investigated by cyclic voltammetry (CV) and UV-Vis spectroscopy. The diffusion coefficient of the free and DNA bound complexes were determined by the Randles-Sevcik equation. The positive peak potential shift in CV suggests an intercalative mode of interaction for these complexes with DNA. The CV results revealed the following decreasing order of binding strengths: (C4H9)2SnLd (1.69 x 104) > (C6H5)2SnLd (1.10 x 104) > (CH3)2SnLd (9.61 x 103) M-1. The results are also supported by the UV-Vis spectroscopic data. The negative values of ∆G indicate the spontaneous nature of this interaction.
فراقؔ گورکھپوری آج کل رگھوپتی سہائے فراق گورکھپوری پر بھی ماتم بپا ہے وہ اس دار فانی سے رخصت ہوئے تو اپنے ساتھ اردو شاعری کی بہت سی رعنائیاں اور جلوہ سامانیاں بھی ساتھ لیتے گئے، فانیؔ، اصغرؔ، جگرؔ اور حسرتؔ کے بعد اردو شاعری کے لال قلعہ کے تخت طاؤس پر بیٹھ کر وہی شاہجہانی کرتے رہے، زبان کی زور آوری، فن کی ہمہ گیری، احساسِ جمال کی مرقع آرائی، رومانیت اور کلاسکیت کی ہم آہنگی غزل گوئی کی آئندہ ساخت و پرداخت میں رہبری، کیفیت و حلاوت کی رنگ آمیزی اور اردو زبان کی بے پناہ محبت کی فراوانی میں وہ یگانۂ روزگار رہے، وہ خود کہہ گئے ہیں: کچھ درد دے گیا ہوں زمانے کو اے فراقؔ یہ سوچ کر کہ بعد میں یہ کام آئیں گے (صباح الدین عبدالرحمن، اپریل ۱۹۸۲ء)
Islam is not a mere set of worships but it leaves no stone unturned to guide its followers regarding the social conduct be it politico-legal, sociocultural or economic etc to name a few. The interest-based transactions have been categorically rendered impermissible and unlawful by virtue of Quranic injunctions and authentic ahadith. In this article the issue of interest based transactions – Muslim to Muslim, Muslim to non-Muslim and vice versa, a Muslim resident of a non-Muslim state and a Muslim non-resident of a nonMuslim state – has been discussed in detail in the light of Quran, hadith and juristic rulings of the eminent Islamic scholars including the great four imams.
This qualitative case study explores the gender equality/inequality related experiences of male and female students in the context of a not-for-profit co-education school in Karachi. In particular, the study examines students' perceptions about their experiences of gender equality/inequality inside and outside classroom. Focused group discussions, semi-structured interviews, observations, drawings and discussion, and document analysis were the main sources of data generation. The study revealed that students' perceptions about themselves were guided by their experiences of gender equality or inequality at school. Their interactions with their teachers and peers appeared to help them define themselves as girls and boys. As such, the boys and girls considered themselves as the two ends of a continuum. They not only experienced gender segregation but many of them desired for such an environment in school. The study showed that both girls and boys experienced different treatment by the teachers inside and outside the classroom which determined their participation in teaching and learning and sports activities. To explore the possibilities of creating a gender equitable environment in the classrooms as well as in the schools, a collaborative action research can be carried out with students. Besides producing contextually relevant knowledge, such a study will help improve gendered practices in schools.