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Home > Synthesis, X-Ray Studies and Biological Evaluation of Thiazine Related Heterocycles

Synthesis, X-Ray Studies and Biological Evaluation of Thiazine Related Heterocycles

Thesis Info

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Author

Muhammad Nadeem Arshad

Program

PhD

Institute

Government College University

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Chemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/handle/123456789/1978

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727530055

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Number of thiazine related heterocyclic compounds were synthesized using various approaches to utilize indigenously available raw materials. The syntheses of targeted molecules were afforded by the easy to handle and cost effective routes with the high possible purity and yield. Synthesis of various 1,2-benzothiazine 1,1-dioxides was accomplished via Heck reaction using ligand free palladium catalyst. It involved synthesis of halogen containing sulfonyl chloride, alkyl/aryl sulfonamide, N-alkylation with different alkenyl groups by conventional methodologies followed by improved Heck cyclization with Pd(OAc) 2 /DIPA in 1-methyl-pyrolidin-2-one or toluene. In this way, two isomeric benzothiazines (with endocyclic & exocyclic double bonds) along with seven membered thiazipene products were obtained. It was also found that endocyclic product dominates over the exocyclic isomer. In accordance with the yield, endocyclic product and thiazipines were isolated in almost equal amounts (38.3% & 37.2%). Synthesis of [Cp*Ru(η 6 -((R)-8-(Hydroxy)-2-S-oxa-2-S-phenyl-2,1- benzothiazine))]Cl for their application as catalyst in chiral synthesis is was also accomplished. Chiral 2,1-benzothiazine derivative was employed to its complexation with cyclopentadiene-Ru salt under microwave radiations. One pot synthesis of a series of N-alkyl 1, 2-benzothiazine 1, 1-dioxide derivatives was carried out from commercially available saccharine with improved yield in less time avoiding extra work-ups. Number of carboxamide derivatives were also synthesized by reacting ester with different amines. Further, methyl 4-hydroxy-2H-1,2- benzothiazine-3-carboxylate-1,1-dioxide , N-alkylated derivatives methyl 4-hydroxy-2- methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide, methyl 4-hydroxy-2-ethyl-2H- 1,2-benzothiazine-3-carboxylate 1,1-dioxide & methyl 4-hydroxy-2-propyl-2H-1,2- benzothiazine-3-carboxylate 1,1-dioxide , and carboxamide derivative N-(2-bromo-4- nitrophenyl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide were oxidized at C-3 carbon to get corresponding alcoholic products which were found dehydrated during crystallization process in methanol.
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