Search or add a thesis

Advanced Search (Beta)
Home > Virologic Response and Safety of Hepatitis C Teatment Regimens in Patients With Hcv 3A Genotype

Virologic Response and Safety of Hepatitis C Teatment Regimens in Patients With Hcv 3A Genotype

Thesis Info

Access Option

External Link

Author

Qureshi, Sadia

Program

PhD

Institute

The University of Lahore

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Biochemistry

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/13254/1/Sadia_Qureshi_Biochemistry_2015_Univ_of_Lahore_13.06.2016.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727661954

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


HCV has been on the top of virus-induced liver diseases in many parts of the world and has gained endemic proportions in our population. Frequency of HCV in Pakistan is significantly higher (4.7%) when compared to the populations of same ethnicity. The hepatitis C virus (HCV) is a small enveloped, single-stranded RNA virus. It is a member of the Hepacivirus genus in the family Flaviviridae. The RNA encodes a large polypeptide of about 3,000 amino acids in a single continuous open reading frame (ORF) which is flanked at the 5'' and 3'' ends by non-translated regions (5'' UTR). Viral load suppression reduces risk of hepatitis C liver morbidity and mortality and prevents progression to cirrhosis, hepatocellular carcinoma (HCC), and decompensated liver disease requiring liver transplantation. Patient race/ethnicity and HCV genotypes also affected the risk of future liver events and death. Multivariate analyses examining socio-demographic and clinical characteristics found that race was the only variable significantly associated with the difference in response rates. So we designed a study to find that how does our local population respond to Hep C treatment regimens and which treatment regimen is effective and safe. Moreover, we also wanted to know that either viral load was correlated to treatment outcome or not. We also planned to do the Pharmacoeconomic analysis of treat regimens. In our study we included adult male / female patients who were seropositive for HCV RNA were tested with real time PCR after an informed written consent. Patients with chronic liver disease, decompensated cirrhosis, anemia (hemoglobin concentration, less than 12 g per deciliter in women and less than 13 g per deciliter in men), psychiatric conditions, seizure disorders, cardiovascular disease, poorly controlled diabetes mellitus, or autoimmune diseases were excluded from the study. Initially 104 patients were evaluated for genotypes and found that 90% of the cases in our local population were infected with HCV 3a genotype. Based on specific prevalence it was decided to compare two treatment regimens (Peg INF+RV & INF+RV) only in patients infected with HCV 3a genotype. We evaluated these treatment regimens for the efficacy and safety both. The required data was recorded on structured data collection form. Their Virologic response was measured at week 0, week 4, week 12, week 24 and week 48 to evaluate treatment efficacy. The initial viral load was also compared with the final out come of the therapy. After the end of the therapy these patients were followed for sustained response. LFTs, RFTs and hematologic parameters were measured on regular intervals to evaluate drug safety. We also did pharmacoeconomic analysis of both treatment regimens being used in our local population to treat Hepatitis C virus infected patients. Our study concluded that though INF+RV treatment regimen was cheaper but Peg INF+RV treatment regimen was more affective in 3a genotype. As far as treatment safety was concerned it was comparable in both regimens. The Virologic response can be used to modify duration of therapy. Moreover, fatty liver can be used as a predictor to assess the final out come of the treatment.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

مولانا شاہ عبدالحلیم جون پوری

مولانا شاہ عبدلحلیم جون پوری
گزشتہ دنوں ضلع جون پور اور اس کے نوح کے مشہور شیخ طریقت اور ممتاز عالم ربانی مولانا شاہ عبدلحلیم صاحب جونپوری رحلت فرماگئے۔ اناﷲ وانا الیہ راجعون۔
مولانائے مرحوم ۱۹۰۷؁ء میں ضلع فیض آباد کے ایک گاؤں دیوریا میں پیدا ہوئے ابتدائی تعلیم مدرسہ عین العلوم ٹانڈہ میں ہوئی۔ مظاہرالعلوم سہارنپور سے سند فراغت حاصل کی۔ ابتداً مظاہرالعلوم ہی میں مدرس مقرر ہوئے مگر طبیعت کی خرابی کی بنا پر جلد ہی اپنے وطن واپس آگئے، یہاں مسلمان بچوں کی ابتدائی تعلیم کے لیے ایک مکتب قائم کیا پھر ترک سکونت کرکے ضلع جونپور کے قدیم مردم خیز قصبہ مانی کلاں میں مستقل بود وباش اختیار کی۔ اور یہیں کے قدیم مدرسہ میں درس و تدریس پر مامور ہوگئے۔ ۱۹۷۳؁ء میں مانی کلاں کو خیرباد کہہ کر اس کے قریب ہی لب سڑک واقع موضع گورینی میں ایک مدرسہ ریاض العلوم کی بنیاد رکھی، جس نے مولانائے مرحوم کی سرپرستی و نگرانی میں بڑی ترقی کی۔
مولانا کی طبیعت کا رجحان ہمیشہ رشد و اصلاح کی طرف رہا، اس نواح میں ان کی ذات سے لوگوں کو بڑا فیض پہنچا، وہ شاہ وصی اﷲ فتح پوریؒ اور شیخ الحدیث مولانا محمد زکریاؒ کے مسترشد اور خلیفہ تھے، جونپور اور اعظم گڑھ کے علاوہ بمبئی اور گجرات وغیرہ میں بھی ان کے مریدین کا بڑا حلقہ تھا، ان کی سرپرستی میں مدرسہ کے احاطہ میں کئی تبلیغی اجتماعات بھی منعقد ہوئے۔ مولانا عبدلحلیم بڑے متواضع، ملنسار اور مقدس بزرگ تھے، ایک مدت سے مختلف عوارض کا شکار تھے، راقم الحروف کو عرصہ سے ان سے نیاز مندی کا شرف حاصل تھا۔ متعدد بار ان کی مزاج پرسی اور عیادت کے لیے حاضر ہوا، مگر کبھی ان کی زبان سے کسی طرح کا شکوہ و شکایت نہیں سننے میں آئی۔ ہر حال میں...

جنات کی حقیقت (اسلامی تعلیمات کی روشنی میں ایک تحقیقی جائزہ)

Some things we can not drive and achieve ethics from wisdom and philosophical thought.  Just as Jinnah (Jinn). Literary word Jinnah (jinn ) is derive from the Arabic alphabet means to hide or  cancel. Thus as their description suggests that  they are invisible physically. Different views has been recorded and reported that these are not a  created being, just a doubt or (whim) but others believe them a creature not a result of any hidden feeling  sense of thought but here sacred jurisprudence (shari’ah) states that they are created one like humans having proper way of  youth and puberty, having domestic life and science suffered towards death lastly human eye can  not see us bound to fulfill the requirement of shari’ah and observed to keep in different sects and tribes persuasion like us. Human and jinnat as power and authority.  Quran proves courtery which we can not ignore. “ I did not create the jinns and human except to worship me”(51/56). Islamic jurisprudence is the best source to prove to existence of jinns with beliefs and thick proof   as Rab e kareem say, s “ Indeed we created man from dried clay of  black smooth mud and we created the jinn before that from the smokeless flame of fire”.(15: 26/27)

Bioavailable Grain Zinc in Wheat Varieties of Pakistan and Strategies for Biofortification

Wheat grains are an important source of minerals and calorie intake especially for human population living in the rural areas of developing countries. Under the widespread zinc (Zn) deficiency in soils and humans, biofortification of wheat grains grown on Zn deficient soils of Pakistan was hypothesized as a possible solution to human Zn deficiency. The research project comprised of six separate experiments focusing on four major issues: i) estimating Zn bioavailability in grains of wheat varieties of Pakistan; ii) evaluating the relationship of grain Zn concentration with soil Zn status ; iii) optimizing rate and application methods of Zn to biofortify wheat grains; and iv) determining the effect of grain milling and flour extraction on Zn bioavailability. The bioavailability of Zn from the grains of selected wheat varieties was low as indicated by high phytate to Zn molar ratio ([phytate]:[Zn]) and low trivariate model of Zn absorption based estimated Zn bioavailability. Currently-cultivated varieties had higher grain yields and lower concentration and bioavailability of Zn than obsolete varieties of Punjab (Pakistan). Much of this variation was related to an increased grain weight in new varieties. Nutrient indexing of Zn in wheat crop and associated soils of cotton-wheat rotation zone of Punjab (Pakistan) indicated widespread soil Zn deficiency and a high risk of human Zn deficiency for the human population of the area. About 75% of surface and all the subsurface soil samples were deficient in plant available Zn resulting in a low grain Zn concentration (20±4 μg g −1 ). In another study, application of Zn significantly increased grain yield, grain Zn concentration and estimated Zn bioavailability while significantly decreased grain phytate concentration and [phytate]:[Zn] ratio in wheat grains. The levels of human requisite Zn concentration and estimated Zn bioavailability in wheat grains were estimated to be achieved at the soil Zn rates required for maximum grain yield (about 9 mg Zn kg −1 soil). Various Zn application methods, alone and in combinations, were evaluated in study 5. Soil Zn application increased grain yield up to 29%, grain Zn concentration up to 95% and estimated Zn bioavailability up to 74%. Foliar Zn application during grain development stage also greatly increased grain Zn concentration especially at lower soil Zn rates (<9 mg Zn kg −1 soil). Soil Zn application at a high rate and foliar Zn spray at heading increased Zn concentration (>50 μg g −1 ) and estimated Zn bioavailability (>3 mg Zn per 300 g flour) in wheat xiiigrains to levels generally desired for improved human nutrition. In the last study, Zn bioavailability from control and biofortified wheat grains was estimated in various grain milling fractions and flours of different extraction rates. Zinc and phytate concentrations and Zn bioavailability were significantly greater in bran compared to other grain milling fractions. There were severe losses in concentration and bioavailability of Zn from both control and biofortified wheat flour at lower flour extraction rates. Moreover, Zn bioavailability was remarkably higher in the biofortified wheat flour as compared to control and commercially available flours. Therefore, biofortified whole-grain flour was suggested for human consumption. As a whole, the project indentified the potential of wheat grown in Pakistan to supply optimum Zn for human nutrition by giving due importance to grain yield under optimum Zn application by suitable methods.