الشھید و اقسامہ مع استعمالاتہ الخاطئتہ فی العصر الحاضر

Islamic concept about Jihad is very different as what is interpreted by the western scholars. This Jihad is not only the name of giving just his own life but to a specific purpose, which is only to create peace and to prevent cruelty and injustice in the society. There are several verses of Quran and Hadith, which explore this concept, but Islam also regulates the rules and regulation for this. To explain the misconception about Jihad, some points have been explored in this research article to guide the people effectively that how jihad should be conducted, while other activities named as “jihad” and an activist intending to take part in such activities might not be counted as a “martyr”. So the important points to be kept in mind are: · In Islam the martyr has a very great value, but in specific terms. · Martyr in Islam is not simply means of giving life. · There are some rules and regulations that must to be followed, i. E., a person must be a Muslim and his intention is only for Allah, and not for his worldly desires, and he follow the rules what Islam justified for the war. · His jihad will not be accepted without the permission of his parents or if he dies in the state of sin etc. · Islam does not allow killing innocent persons, Muslims or non-Muslims, without caring the color and caste, if he does so he would be answerable to Allah.

Kras Oncogenic Mutation Pattern in Pakistani Patients Presenting With Colorectal Adenocarcinoma in a Northern Tertiary Referal Centre

Veterinary Pathology Pathology Abstract Colorectal cancer is a global disease with marked morbidity and mortality. Involvement of genetic and environmental factors produces variability in its prevalence. KRAS (Kirsten rat sarcoma viral oncogene homologue) is one of the important genes responsible for sporadic CRC. The constitutive GTPase activity of the gene is lost when it gets mutated and so the deregulated cells undergo unrestricted proliferation leading to oncogenesis. From therapeutic point of view, patients with KRAS mutations do not benefit from epidermal growth factor receptor inhibition drugs as those who possess normal KRAS. The analysis of KRAS mutations is therefore important from both diagnostic as well as therapeutic purposes. Diagnostic methodology and the valuable information of this study will be quite helpful in future. The objectives of this study were to document the KRAS oncogenic mutation pattern mostly in Northern Pakistani residents presenting in AFIP, Rawalpindi after their intestinal resection due to CRC. The other objective was to relate this mutation pattern with histopathological categorical variables like age, gender, presenting clinical complaint, tumor site, size, histological differentiation, modified Duke Stage of tumor, nodal metastasis and metastasis in other organs. Hundred and eighty one cases of CRC from persons residing in northern area of Pakistan were collected and observed for the above mentioned parameters. DNA was extracted from the tumors and normal tissues of all the study subjects. PCR was done for gene amplification and the status of KRAS mutations in Pakistani CRC patients was analyzed by gene sequencing. The results showed more prevalence of CRC in the males of northern areas of Pakistan. Both males and females with higher average age had high tendency to acquire CRC. Rectum was found to be the most common location of CRC, followed by sigmoid. Exophytic well differentiated adenocarcinomas were the most common form of CRC. Gene sequencing did not show even a single KRAS mutation in the tested samples. It can be inferred from this study that either there is no KRAS mutation in northern area patients suffering from CRC or the mutation frequency of this particular gene is relatively very low as compared to the results of studies reported in the literature. A wider scale study of these patients may prove the cause of CRC to be due to mutation of some other genes or may be due to some non-genetic factors.