A high performance algorithm for the implementation of Arbitrary Lagrangian and Eulerian (ALE) moving mesh scheme for both 2D and 3D Fluid Structure Interaction (FSI) problems for the shared and distributed memory systems is discussed in the the- sis. OpenMP library is used to implement parallel programs on shared memory systems whereas message passing interface (MPI) is employed to write parallel programs on dis- tributed memory systems. Moving mesh techniques are the integral part of a wider class of fluid mechanics problems that involve moving and deforming spatial domains, namely, free-surface flows and FSI. The moving mesh technique adopted in this work is based on the notion of nodes relocation, subjected to certain evolution as well as constraint conditions. A conjugate gradient method augmented with a preconditioning is employed for the solution of the resulting system of equations. The proposed algorithm, firstly, re- orders and partitions the mesh using an efficient divide and conquer approach and then parallelizes the ALE moving mesh. Different mesh partitioning algorithms are discussed, which include the octree method, and k-way graph partitioning technique using Parmetis library. Numerical simulations are conducted on AMD Opteron and Intel Xeon processors, and unstructured triangular and tetrahedral meshes are used for the 2D and 3D prob- lems. The better results, in terms of the speedup, are obtained for the shared memory system than the distributed memory system for both the 2D and 3D problems. The quality of meshes is checked by comparing the element Jacobians in the reference and current meshes, and by keeping track of the change in the interior angles in triangles and tetrahedrons. The proposed parallel mesh reordering algorithm using sampling approach for work load re-distribution concluded 51% of average efficiency in term of the speedup for shared memory systems. The overall maximum speedup of 6.37, for the shared mem- ory system, is achieved using eight processing elements (PEs) as compared to 4.11 for the distributed memory system including twelve PEs. As a case study, the thesis also discusses the high performance implementation of a stabilized mixed finite element method for Darcy flow using MPI library. It has a lot of practical applications in the field of petroleum engineering and earth sciences especially, where the flow of fluid is of interest in a permeable porous medium. The maximum speedup of 12.24 is achieved using 28 PEs by incorporating the proposed mesh partition- ing algorithm. Outline Chapter 1 defines and introduces the problem statement and Chapter 2 gives the gen- eral introduction of the thesis. Chapter 3 presents the literature review of ALE moving mesh generation, stabilized mixed finite element methods, k-way graph partitioning algo- rithm and tree based spatial data structures. Chapter 4 mathematically formulates the ALE mesh generation problem and presents the serial algorithm for optimization using the preconditioned conjugate gradient method. Chapter 5 presents a mesh reordering algorithm based on quadtree/octree and quick sort techniques. Chapter 6 discusses the parallelization part of mesh reordering algorithm based on a sampling approach and also discusses the experimental results for the shared memory systems. Detailed discussion about the mesh partitioning and experimental results using MPI are given in Chapter 7. Chapter 8 briefly describes the stabilized finite element method for Darcy Flow and dis- cusses the results of 2D problems for a distributed memory system. Finally, conclusions are drawn in Chapter 9 and future work is presented in Chapter 10.
موضوع4: زبان کے خاندان زبانیں کیسے پیدا ہوئیں؟اس سوال کے جواب پر ماہرین متفق نہیں ہیں۔ کسی نے کہا ہے غیر ذی روح اشیاء مثلاً پانی، ہوا وغیرہ کے شور کی نقل سے الفاظ بنائے گئے۔ کسی نے دعوی کیا کہ حیوانات کی آوازوں سے الفاظ اخذ کئے گئے۔ کوئی انسان کی ضطراری یا نعروں کو زبان کی بنیاد قرار دیتا ہے۔ ان قیاس آرائیوںکی بنا پر بہت کم الفاظ کا پتا چلتا ہے۔ ایک بات قابل توجہ ہے، حیوانات اور انسان کو خواص خمسہ اور جبلتیں عطا ہوئی ہیں۔ انسان کو علم ،شعور ارادہ ،اختیار اور قوت گویائی سے بھی نوازا گیا۔ حواس خمسہ اور جبلتوں کے علاوہ ان مذکورہ اوصاف سے گویائی یا بیان کا گہرا تعلق ہے جس نے یہ صفات عطا کیں،اسی نے قوت گویائی بھی عطا کی۔گویائی یا بیان بھی اسی کی دین ہے۔ سورۃ رحمٰن کی تیسری اور چوتھی آیت میں بتایا گیا ہے کہ اللہ عزوجل نے انسان کو پیدا کیا اور اسے بولنا سکھایا( اسے زبان عطا کی)۔ فرنچ اکیڈمی کے نزدیک دنیا میں 2796 زبانیں ہیں۔شمالی امریکہ میں 351،میکسیکو اور وسطی امریکہ میں96 اور جنوبی امریکہ میں783۔ یہ امریکہ کے قدیم باشندوں ، امریکی ہندیوں(Red Indians) کی زبانیں ہیں۔ان کی صحیح گروہ بندی ابھی تک نہیں ہوئی۔بیشتر زبانوں کا مطالعہ کم ہوا ہے۔ جزائر بحرالکاہل کی زبانوں کا پورا مطالعہ بھی نہیں ہوا۔تقریبایہی حال افریقی زبانوں کا ہے جنہیں چار گروہوں میں تقسیم کیا جاسکتا ہے۔یہ گروہ حسب ذیل ہیں :(جہاں زبانوں کی تعداد لکھیں ہے وہاں زبانوں سے بیشتر بولیاں مراد ہیں)۔ 1۔سوڈان گنی گروہ: 435 زبانیں۔یہ گروہ مشرقی افریقہ سے مغربی افریقہ تک، خط استوا کے اوپر پھیلا ہوا ہے۔ ۔بانتو خاندان: 83زبانیں۔۔۔۔یہ خاندان افریقہ کے وسطی اور جنوبی حصوں میں پھیلا ہوا ہے۔ 3۔لش مین گروہ: 6 زبانیں۔ 4۔حامی سامی خاندان: 46 زبانیں۔(حام اور سام...
Imam Khattabi is considered as a glorious scholar of the fourth century. He has written several books in various scholarly traditions. One of them an important book is "Ghareeb ul Hadith". In this, he has not only interpreted the difficult words but also referred to as Ayaat, Ahadith and verses etc. Then, he also described the jurisprudential commandments existed in these Ayaat and Ahadith. Furthermore, in many places, hadith terms, legal maxims and wisdom of law are also part of this book. This book also holds a significant correlation with knowledge of Imam Khattabi's teachers because he mentioned the ahadith and sayings of scholars with his own chain. Due to these qualities of this book, not only did the scholars of language use it, but also magnificent mohaddiseen, jurists, explainers and researchers have also quoted it in their own books. Of course, it will not be unwise to say that like previous scholars and mohaddiseen this book is also important and need for today's scholars.
Alpha-thalassemia is an inherited blood disorder which is an autosomal recessive type
disorder characterized by a microcytic hypochromic anemia and hemolytic anemia. The
a-thalassemias involve the genes?HBA1?and?HBA2.The aim of this research was to determine
the mutations in hemoglobin alpha 1 (HBA1) in Thalassemia affected patients and in silico
analysis of identified mutations to predict the functional effect. In this study, genomic DNA
was extracted from 40 Patients affected with Thalassemia (n=40) disease. Blood samples
were collected in vacutainers with EDTA as an anticoagulant from the patients and relatives.
Blood samples with anticoagulant were used for leukocytes based DNA extraction. Standard
organic method was used for DNA extraction. DNA samples were quantified using agarose
gel and DNA ladder. Primers were designed using gene sequence from NCBI gene bank.
Primer3 software was used for primer designing. PCR conditions will be optimized for
amplification and PCR was performed to determine the SNPs. A 382 base pair fragment of
DNA of HBA1gene of exon 3 was amplified using polymerize chain reaction (PCR)
technique. Sanger sequencing of the selected samples was done to identify polymorphisms.
A total of 24 samples out of 40 samples of DNA were sequenced and these SNPs were
confirmed by alignment. We were unable to find the mutations in the HBA1 gene but two
heterozygous variations were found in HBA1exon 3.Two
heterozygous
variations were confirmed in exonic area of HBA1 gene of
Patients affected with Thalassemia. The findings of this
research revealed no mutations were found in HBA1 gene. Two
heterozygous variants were confirmed at the position of c.514
on amplified fragment from G> C and second change at the
position of c.470 on amplified fragment G > C in 3?UTR..
Variations were further subjected for splice site analysis.
The splicing site analysis was done by using an online tool
(Human splicing finder).A variation which were present at
c.514 G>C were found in the potential splice site and its
consensus value is 88.39 and the second one is not in the
target region of splicing.