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Home > Lung Cancer Classification With Discriminant Features of Mutated Genes Using Machine Learning

Lung Cancer Classification With Discriminant Features of Mutated Genes Using Machine Learning

Thesis Info

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External Link

Author

Sattar, Mohsin

Program

PhD

Institute

Pakistan Institute of Engineering and Applied Sciences

City

Islamabad

Province

Islamabad.

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Computer Science

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/11487/1/Mohsin%20Sattar%20CS%20year%202019%2003-7P1-002-2014.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727785199

Similar


Machine learning based mathematical and statistical models are employed for the development of improved classification systems. These decision based systems have the capability of automatically learning from complex sequential data. In this work, machine learning models are developed for the classification of lung cancer. The early classification of lung cancer is critical for successful cancer treatment. Genes and proteins are important in the normal functioning of the human body. The abnormal processes due to somatic mutations transform normal cells into cancer cells. The somatic mutations in genes are ultimately reflected in gene expression and proteins amino acid sequences. Influential information is extracted during the statistical analysis of gene expression and proteins amino acid sequences data. This information is transformed into discriminant feature spaces using physiochemical properties. The machine learning capability is exploited effectively using discriminant information of mutated genes in proteomic and genomic data.This study aims to develop artificial intelligent lung cancer classification systems. The development was carried out in three main phases. In the first phase, lung cancer classification system using protein amino acid sequences is developed by employing various individual learning algorithms. In the second phase, lung cancer classification system using protein amino acid sequences is developed by employing multi-gene genetic programming. This approach exploits evolutionary learning capability by optimally combining the selected discriminant features with primitive functions. The third phase is focussed on the development of improved lung cancer classification system using influential features of gene expression with the imbalanced dataset by employing rotation forest. In the thesis work, extensive experiments are conducted to evaluate the performance of various lung cancer classification systems. The proposed systems have obtained excellent accuracy values in the range of 95%99%. The comparative analysis highlights that proposed lung cancer classification systems are better than previous approaches. It is expected that research outcome would impact in the fields of diagnosis, prevention, and effective treatment of lung cancer.
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مڈھلی گل

مڈھلی گل

                آکھیا جاندا اے کہ حیاتی وچ ترقی کرن لئی کسے سیانے بندے دی لوڑ ہوندی اے۔ جو تہانوں حیاتی دے رستے دیاں اوکڑاں توں جانوں کروا کے تہاڈی آگوائی کرسکے۔ میرے نال وی حیاتی وچ کجھ انج ای ہویا۔ میرا تعلق ضلع مظفر گڑھ دے اک پنڈ ۶۴۷ ایم۔ بی نال اے۔ دسویں کرن پچھوں مظفر گڑھ کالج وچ داخلہ لیا، پر انٹر ایس پاروں نہ کرسکیا کہ ہاسٹل دی سنگت نے صرف ہاسٹل انجوائے کرن دتا۔ پڑھائی ول دھیان گھٹ ای رہیا۔ پر ایس حیاتی دا ایہہ فائدہ ہویا کہ ادب نال میری دلچسپی ودھی۔ کیوں جے کالج پرتن مگروں سنگی دوہڑے آکھدے ہوندے سن یاں فیر کوئی گیت گاؤندے سن۔ پہلاں پہل ایہہ کم چنگا نہ لگا۔ فیر ہولی ہولی شاعری وچ دلچسپی ودھی تاں سرائیکی دے کئی شعر زبانی یاد ہوگے۔ ایہو اوہ ویلا سی جدوں میں وی شاعری نوں منہ مارنا شروع کیتا۔ پر چھیتی ای احساس ہوگیا کہ ایہہ میرے وس دا روگ نئیں۔ پر طبیعت کجھ نہ کجھ لکھن نوں کردی سی۔ ایس لئی ماڑی چنگی کہانی لکھنا شروع کیتی۔ پر سجناں ولوں اسارو ہنگارانہ ہوون پاروں میں ایہہ کم چھڈ دتا۔ ایس پچھوں میں کم کار لئی فیصل آباد آگیا۔

                فیصل آباد مڑ پڑھن دا من کیتا تے ایس دوران ڈاکٹر محمد ایوب ہوراں نال ملاقات ہوئی۔ اوہناں پڑھائی وچ مدد کرن دے نال نال میرے شوق دی...

مولانا مناظر احسن گیلانی اور ان کی صوفیانہ فکر

Juristic rules laid the foundation of law, along with such juristic rules, Islām promotes the values of piety (through mystic guidelines). Most of the theologians opine that the real approach to get close the Creator can only be achieved through the mystic guidelines. In the early period of Islām, during the time of the prophet, , caliphate guided rightly the of periods the during and (صلى الله عليه وسلم) Muhammad when people were trained in a very righteous environment, there were no such reservations about the applications of clear jurisprudential injunctions along with the mystic guidelines, but, when Muslims tasted the grandeur of rule, regime and abundance of wealth, they indulged in the worldly affairs and adopted a materialistic approach, not only in their daily life, but, toward their religion, too. The Muslim thinkers have been trying to define and explain whether the typical rituals of mysticism are reconcilable with the larger demands of an Islamic vocabulary. Despite the wide diversity of the critical approaches, a certain pattern has been identified by Muslim responses as mysticism, which is, sometimes found closer to asceticism and sometime as a mediator. Many Muslim mystics have dealt with mysticism, but, perhaps, Manāẓir Aḥsan Gīlānī has displayed, with reference to Ibn ‘Arabī and Shāh Walī Ullāh, the most impressive and knowledgeable applications of such mystic ideas within an Islamic framework. Manāẓir’s applied mysticism is not a typical mysticism; his special focus upon legal injunctions of al-Sharī‘ah goes much further than any of his peers in establishing a strong framework for better understanding of Islām. This study is devoted to examining the effects and implications of mysticism, not only for individuals, but also for the Muslim masses, generally.

Electrochemical Assay of Various Polymeric Products for Phthalate Contents

Phthalates are widely used as plasticizer in polymeric products, deodorants, nail polish, printer inks, insecticides, toys, PVC shower curtains, lubricants, food wraps, blood-bags, catheters, etc. They can disrupt endocrine functions and induce reproductive and developmental problems. Because of the ubiquity of phthalates and their potential role in increasing risk for cancer and reproductive dysfunction, there is an ever increasing demand for analytical methods suitable for their monitoring in various environmental and biological matrices. The present work addresses the development of four new polarographic and voltammetric methods for the determination of the mentioned toxic organic compound in polymeric products. In the first part of the study a faster, simpler and sensitive method was developed for determination of aliphatic phthalates using differential pulse polarography (DPP) as standard technique. The choice and concentration of base electrolyte, solvent, initial potential, effect of water addition and interference by other phthalates were the main parameters to optimize for enhancement of peak current and to obtain well-defined polarogram with lower background current using 1.3 x 10-4 mol L-1 dibutyl phthalate (DBP) solution. Best results were obtained in the presence of tetra methyl ammonium bromide (TMAB) as electrolyte in methanol solvent with initial potential, -1.4 V. A linear calibration plot was observed in the range of 3 x 10-7 – 1.6 x 10-4 mol L-1 DBP solution as model for aliphatic phthalates with lower detection limit of 5.9 x 10-8 mol L-1 and linear regression coefficient of 0.9987. The developed polarographic method was successfully applied for analysis of aliphatic phthalates in various samples of locally available polymer products such as baby toys, nipples, teethers, infusion blood bags and shopping bags. The results of the current method were compared with those obtained by a reported method and good agreement was found between them. A fast, simple and highly sensitive Square Wave Voltammetric (SWV) method was developed for determination of total water soluble phthalates using 95% dibutyl phthalate (DBP) as an example at glassy carbon electrode (GCE). The study showed that 100 μmol L-1 aqueous solution of DBP gives best response with 0.05 mol L-1 Tetra butyl ammonium bromide (TBAB), at stirring rate of 1400 rpm, deposition time, 20 s and pH value, 4.0±0.1. The optimum frequency and scan rate was 100 Hz and 0.9 V/s respectively. Voltammetric response was linear in 3 ranges, 70–110 μmol L-1, 20–60 μmol L-1 and 2–10 μmol L-1 with correlation coefficient of 0.9873, 0.9978 and 0.9935 respectively and limit of detection (LOD), 0.47 μmol L-1 for total water soluble phthalates in aqueous medium. The developed method was successfully applied for total phthalates determination in various samples of water stored in PVC coolers and plastic bottles. A new simple, fast and sensitive differential pulse voltammetric method was developed for the determination of different aliphatic phthalates. Dibutyl phthalate (DBP), diethyl phthalate (DEP), didecyl phthalate (DDP), and diallyl phthalate(DAP) can be determined in 0.1 mol L-1 TMAB methanol using a hanging mercury drop minielectrode and a meniscus modified silver solid amalgam electrode. Optimum conditions were found including concentration and composition of supporting electrolyte and solvent, scan rate, pulse amplitude, pulse width, etc.. Both peak potentials and peak heights of DEB, DBP, and DDP are similar suggesting the possibility to determine their mixture by measuring the total peak height of the mixture of these three substances and the DPV peak of DAP is shifted to less negative potential because of electron withdrawing effect of allyl substituent which, is in agreement with negative value of Hammett constant for allyl (σp = –0.14). The results showed that the peak potential of model mixture of these phthalates do not differ by more than ± 15 mV from peak potentials of individual phthalates and experimentally found peak heights corresponding to different model mixtures do not differ by more than 10 % (HMDmE) or 20 % (m-AgSAE) from the calculated sum corresponding to individual compounds present in the model mixtures. It was verified using model mixture containing different concentrations of DEP, DBP, and DDP (the total concentration being in the range 2–10x10-6 mol L-1 that an approximate estimation of the sum of above mentioned substances can be carried out with relative error around ± 20 % for HMDmE and ± 30 % for m-AgSAE, respectively. Due to the risk associated with mercury toxicity, there is an increasing trend among analytical chemists to replace mercury with some non toxic electrode materials. For this purposed new voltammetric method have been developed for the determination of aliphatic phthalate such as DBP, DEP, DDP, and DAP esters at newly synthesized silver amalgam paste electrode ( AgA–PE) Another simple, faster, and sensitive differential pulse voltammetric method was developed for the determination of different aliphatic phthalates such as DBP, DEP, DDP, and DAP in 0.1 mol L-1 TMAB in methanol solvent. Optimum conditions were found included concentration and composition of supporting electrolyte, methanol as solvent, scan rate, pulse amplitude, pulse width, etc. Linear calibration curves were obtained from 1 x 10-5 to 1 x 10-6 mol L-1 concentration range for different aliphatic phthalate esters. These newly investigated methods are more efficient, economical and sensitive for the analysis of the phthalic acid or phthalate esters in different media. Electroanalytical equipments are very economical and these newly developed methods can be adopted at domestic and industrial scale for continuous monitoring of these phthalates at trace levels in various polymeric products, plastic bottled waters, and cooler waters etc as for recommendations by WHO, EPA and other health / environmental organizations.