پتھر کی دنیا
آج بھی دنیا پتھّر کی ہے
نہیں ہے بدلی ریت ہماری
کوئی بھی چیز نہیں ہے بدلی
پیار نہیں سمجھے گا کوئی
آ اِس پتھّر کی دنیا میں
میں بھی پتھّر ہو جاتا ہوں
تم بھی پتھّر کے ہو جائو
آ اِس پتھّر کی دنیا میں
ہم بھی پتھّر ہو جاتے ہیں
اب بھی دنیا پتھر کی ہے
اِس کی ہر شے پتھر کی ہے
چاند بھی پتھر تارے پتھر
چشمے پتھر دھارے پتھر
ریت رواج ہمارے پتھر
آ اِس پتھّر کی دنیا میں
ہم بھی پتھّر ہو جاتے ہیں
آ اِس پتھّر کی دنیا میں
ہم دونوں پتھّر ہو جائیں
Chronic hepatitis C is a major health problem associated with high mortality and morbidity. It is the most common chronic blood borne infection leading to chronic liver disease and hepatocellular carcinoma. One of the treatment used for hepatitis C is interferon therapy which can lead to thyroid dysfunction i.e. Hyperthyroidism and hypothyroidism. OBJECTIVE: “To assess the frequency of hypothyroidism in chronic hepatitis C patients treated with standard interferon therapy”. METHODS: Thisdescriptive case series study was carried out at Outpatient Department of Medicine, King Edward Medical University/ Mayo Hospital Lahore for 06 months from July to December 2014. After ethical approval of the study, 200 patients of ages 15 to 65 years with both genders having chronic hepatitis C on Polymerase chain reaction (PCR)& normal thyroid functionstest were taken by Non-probability, purposive sampling technique. Informed written consent was taken from all the patients. Serum thyroid stimulating hormone level (TSH) was sent of all patients to Centre for Nuclear Medicine (CENUM), Mayo Hospital Lahore before and after the completion of three months of interferontherapy and hypothyroidism was considered as TSH>4.0 mIU/L (normal range: 0.2-4.0 mIU/L). RESULTS: The mean age of the patients was 36.29 + 8.5 years. Out of total 200 patients, 123 (61.5%) were male and 77 (38.5%) were female. At baselines mean TSH of the patients was 3.16 + 2.57 mIU/L. After 3 months of therapy 163 patients (81.5%) were euthyroid and 37 patients (18.5%) were having thyroid dysfunction. Among patients with thyroid dysfunction 29 (14.5% of total patients) were hypothyroid. Among hypothyroid patients, according to gender distribution 8 (27.6%) patients were male and 21 (72.4%) patients were female. The difference was statistically significant (P=0.0003). CONCLUSION: It is concluded from this study that there is significant frequency of hypothyroidism in patients of chronic hepatitis C treated with standard interferon therapy and females are at more risk of developing thyroid dysfunction particularly hypothyroidism after standard interferon therapy.
The best-planned development of any area is possible when the problems of that area are well understood, well documented and closely monitored. The central city has always been a spatial location of significance although its characteristic qualities have varied considerably over time and space. This study focuses on the internal structure of the years 2007 and 2014, which refers to the arrangement of land uses of the downtown (Saddar area) of Karachi. During the past half a century, the arrangement of land uses has been focused in study of western cities however such studies pertaining to Non-Western Cities are limited in number. This has been the chief stimulating factor behind the selection of this research. Saddar area of Karachi historically has always been recognized as the main shopping center of Karachi. Apart from commercial activity, which is the major activity, the area has substantial amount of residential function, educational, administrative and many other recognized land uses. The purpose of the study is to pinpoint the salient features of internal structure of the downtown area based on the spatial arrangement of its land uses. The analyses of this study utilized quantitative and qualitative data collected through intensive field inventory and interviews. Apart from traditional cartographic techniques the study has made full use of modern technique, Geographical Information System (GIS). This study indicates the changes that have occurred in the land uses and commercial functions in the downtown Saddar. As a result of this research, it has been possible to solve the problems like traffic congestion, poor road infrastructure, huge number of hawkers along the road side & foot path causing problems for pedestrians, old and damaged buildings not in use, lack of inter-shops space, noise pollution, air pollution, parking issues, drinking water problems, residential problems for migrants (job seekers) etc.