Search or add a thesis

Advanced Search (Beta)
Home > Robust Algorithm for Genome Sequence Short Read Error Correction Using Hadoop-Mapreduce

Robust Algorithm for Genome Sequence Short Read Error Correction Using Hadoop-Mapreduce

Thesis Info

Access Option

External Link

Author

Tahir, Muhammad

Program

PhD

Institute

Iqra University

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Computer Science

Language

English

Link

http://prr.hec.gov.pk/jspui/bitstream/123456789/7315/1/Muhammad_Tahir_Computer_Science_2016_Iqra_Univ_10.05.2016.pdf

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676727826301

Similar


Biological sequences consist of A C G and T in a DNA structure and contain vital information of living organisms. The development of computing technologies, especially NGS technologies have increased genomic data at a rapid rate. The increase in genomic data presents significant research challenges in bioinformatics, such as sequence alignment, short-reads error correction, phylogenetic inference, etc. Next-generation high-throughput sequencing technologies have opened new and thought-provoking research opportunities. In particular, Next-generation sequencers produce a massive amount of short-reads data in a single run. However, these large amounts of short-reads data produced are highly susceptible to errors, as compared to shotgun sequencing. Therefore, there is a peremptory demand to design fast and more accurate statistical and computational tools to analyze these data. This research presents a novel and robust algorithm called HaShRECA for genome sequence short reads error correction. The developed algorithm is based on a probabilistic model that analyzes the potential errors in reads and utilizes the Hadoop-MapReduce framework to speed up the computation processes. Experimental results show that HaShRECA is more accurate, as well as time and space efficient as compared to previous algorithms.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

ہندوستانی اقبال شناس سید مظفر حسین برنی کے سوانح،آثار اور علمی و ادبی خدمات

ہندوستانی اقبال شناس سید مظفر حسین برنی کے سوانح،آثار اور علمی و ادبی خدمات
فکرِ اقبال کو پروان چڑھانے اور ملتِ اسلامیہ کو بیدار کرنے کے لیے بہت سے ماہرین نے اقبال کے نظریات پر روشنی ڈالی ہے۔ اقبالیات کے موضوعات کی تفسیر و توسیع کے لیے بہت کچھ لکھا۔اس محنت کی بنا پر ایسے لوگ اقبا ل شناس کہلائے اور عوام میں پذیرائی حاصل کی۔ایسا ہی ایک نام سید مظفر حسین برنی بھی ہے۔آپ نے اقبال کے خطوط کو زمانی اورتاریخی ترتیب دی اور عوامی حلقوں میں پذیرائی حاصل کی۔آپ کا تعلق”برن“ (بلند شہر) کے ایک ذی وقار خانو ادے سے ہے۔
آپ 14۔ اگست 1923ء کو بلند شہر میں پیدا ہوئے اور آپ نے 7 فروری 2014ء کو دہلی میں وفات پائی ۔ آپ نے جس گھرانے میں آنکھ کھولی تھی اس میں خدمتِ علم وادب کی ایک طویل اور مسلسل روایت رہی ہے۔آپ کا تعلیمی سلسلہ بہت عمدہ رہا۔ بی۔اے میں انگریزی ادب میں ٹمپیل گولڈ میڈل حاصل کیا۔پھر انگریزی ہی میں ایم۔اے بھی کیا۔ 1947ء میں انڈین ایڈمنسٹریٹو سروس”آئی اے ایس“ کے مقابلہ کے پہلے امتحان میں کامیاب ہوئے اور ریاست اڑیسہ میں تعینات کیے گئے۔
مرکزی حکومت نے آپ کی صلاحیتوں سے بھر پور استفادہ کیا۔آپ جوائنٹ سیکرٹری کمیونٹی ڈویلپمنٹ رہے۔محکمہ زراعت میں جوائنٹ سیکرٹری رہے۔ایڈیشنل سیکرٹری وزارتِ پٹرولیم وکیمیکلزکاانتظامی عہدہ سنبھالے رکھا۔وزارتِ اطلاعات و نشریات کے اہم ترین ادارے میں سیکرٹری رہے۔بورڈ آف ریونیو میں رلیف کمشنر رہے۔چیف سیکرٹری اور ڈویلپمنٹ کمشنر کے اعلیٰ ترین عہدوں پر ذمہ داریاں سر انجام دیں۔وزارتِ داخلہ میں سیکرٹری جیسے عہدے پر کام کر کے نیک نامی حاصل کی۔ناگا لینڈ،منی پور،تری پورہ اور ہریانہ کے گورنر رہے۔مرکزی حکومت کے اقلیتی کمیشن کے چیرمین رہے۔پبلک سیکٹر کے تقریباً آٹھ اداروں میں ڈائریکٹر کی حیثیت سے ذمہ داریاں سرانجام دیں۔بہت سی بین الاقوامی کانفرنسوں میں شرکت کی...

جنگی جرائم اسلام اور بین الاقوامی قانون کے تناظر میں

In ancient and modern era wars, such war crimes are committed which are against humanity and peace. The war crimes committed were only for power pelf  and pomp. The  continuation of those war crimes is still present in modern time wars. Islam has introduced a very civilized, meaningful and judicious  way for war fare  against enemy and also eradicated all kind of  war crimes.

Analytical Characterization of Lipids and Antioxidant Components in Flaxseeds Linum Usitatissimum

Flaxseed or linseed (Linum usitatissimum) belonging to family lineaceae is an ancient crop and has been grown for its fiber (linen) and oil seeds since 9000 to 8000 B.C. Flaxseed is cultivated in almost fifty countries of the world including Pakistan. Flaxseed is a rich source of alpha linolenic acid, very efficient antioxidant system and dietary fiber. These characteristics and the health benefits associated with these characteristics of flaxseed have made it a great attraction for the researchers in the field of functional foods and neutraceuticals. Keeping in view the immense importance of flaxseed as neutraceutical and functional food, the present study was planned to assess the nutritional composition, oil characteristics and antioxidant potential of different flaxseeds cultivars grown in Pakistan. Moreover qualitative and quantitative analysis of the flaxseed phenolics was done by HPLC and LC-MS. The proximate analysis of flaxseed that the oil, moisture, crude protein, fiber and ash contents in the seeds of different cultivars of flaxseed were observed to range from 33.25 to 38.38%, 5.98 to 6.22%, 16.02 to 18.50%, 23.30 to 26.80% and 3.21 to 3.60% respectively. Gamma tocopherol was observed to be the major tocopherol present in the oil with minor contents of alpha tocopherol. The unsaturated fatty acids in the oils extracted from different cultivars were observed to be in the range of 88.79 to 89.78%, with alpha linolenic acid with the highest contents and ranged from 44.51 to 54.87%. From the data for the physicochemical characteristics of the oils it was observed the oils were up to the mark in quality as compared to the international standards. 80% aqueous ethanol and methanol were the most effective solvents for recovering antioxidant components from flaxseed while the pure ethanol and acetone had shown the least efficacy towards isolation of flaxseed antioxidants as established by the antioxidant activity analysis by different methods. Furthermore, the sonication assisted shaking proved to be superior in extraction of antioxidant components. HPLC and LC-MS analysis established that SECO (secoisolariciricinol) was the major phenolic (lignan) and dominated all the other phenolic compounds. SDG, ferulic acid, coumaric acid, chlorogenic acid and gallic acids were the other phenolic compounds detected in the flaxseed. The data presented would certainly help to ascertain the potency of the flaxseeds grown in Pakistan, as viable source of natural antioxidants and alpha linolenic acid, thus suggest their uses for nutraceutical and functional food applications.